This dissertation used the risk and resilience framework to examine the associations between perceived racial discrimination, family racial socialization, nativity status, and psychological distress. Regression analyses were conducted to test the links between perceived racial discrimination and psychological distress and the moderation on these associations by family racial socialization and nativity status. Results suggest, for U.S.-born adolescents, cultural socialization strengthened the relation between subtle racial discrimination and anxiety symptoms. In addition, promotion of mistrust buffered the relations of both subtle and blatant racial discrimination on depressive symptoms. For foreign-born adolescents, promotion of mistrust exacerbated the association between blatant racial discrimination and depressive symptoms. Overall, the findings revealed the detrimental effects of perceived racial discrimination on the mental health of Asian American adolescents, how some family racial socialization strategies strengthen or weaken the relation between perceived racial discrimination and psychological distress, and the different ways foreign-born and U.S-born adolescents may interpret racial discrimination and experience family racial socialization.