Modeling and Characterization of Mass Transfer Kinetics in Tumor Tissue Using Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI)

The objective of the research presented here was to validate the use of kinetic models for the analysis of the dynamic behavior of a contrast agent in tumor tissue and evaluate the utility of such models in determining kinetic properties - in particular perfusion and molecular binding uptake associated with tissue hypoxia - of the imaged tissue, from concentration data acquired with dynamic con