Investigation of Cell Media and Aminoglycoside Hydrogel Properties for Cancer Cell Dormancy
Description
In a dormant state, cancer cells survive chemotherapy leaving the opportunity for cancer cell relapse and metastasis ultimately leading to patient death. A novel aminoglycoside-based hydrogel ‘Amikagel’ developed in Dr. Rege’s lab serves as a platform for a 3D tumor microenvironment (3DTM) mimicking cancer cell dormancy and relapse. Six Amikagels of varying mechanical stiffness and adhesivities were synthesized and evaluated as platforms for 3DTM formation through cell viability and cell cycle arrest analyses. The impact of fetal bovine serum concentration and bovine serum albumin concentration in the media were studied for their impact on 3DTM formation. These experiments allow us to identify the best possible Amikagel formulation for 3DTM.
Details
Contributors
- Gjertsen, Haley Nicole (Author)
- Rege, Kaushal (Thesis director)
- Grandhi, Taraka Sai Pavan (Committee member)
- Chemical Engineering Program (Contributor)
- Barrett, The Honors College (Contributor)
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2016-05
Topical Subject
Resource Type
Language
- eng
Additional Information
English
Series
- Academic Year 2015-2016
Extent
- 20 pages