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Background
The maintenance of chromosomal integrity is an essential task of every living organism and cellular repair mechanisms exist to guard against insults to DNA. Given the importance of this

Background
The maintenance of chromosomal integrity is an essential task of every living organism and cellular repair mechanisms exist to guard against insults to DNA. Given the importance of this process, it is expected that DNA repair proteins would be evolutionarily conserved, exhibiting very minimal sequence change over time. However, BRCA1, an essential gene involved in DNA repair, has been reported to be evolving rapidly despite the fact that many protein-altering mutations within this gene convey a significantly elevated risk for breast and ovarian cancers.
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    Date Created
    • 2014-07-11
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1186/1471-2148-14-155
    • Identifier Type
      International standard serial number
      Identifier Value
      1471-2148
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    Lou, D. I., Mcbee, R. M., Le, U. Q., Stone, A. C., Wilkerson, G. K., Demogines, A. M., & Sawyer, S. L. (2014). Rapid evolution of BRCA1 and BRCA2 in humans and other primates. BMC Evolutionary Biology, 14(1), 155. doi:10.1186/1471-2148-14-155

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