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We introduce and solve a ‘null model’ of stochastic metastatic colonization. The model is described by a single parameter θ: the ratio of the rate of cell division to the

We introduce and solve a ‘null model’ of stochastic metastatic colonization. The model is described by a single parameter θ: the ratio of the rate of cell division to the rate of cell death for a disseminated tumour cell in a given secondary tissue environment. We are primarily interested in the case in which colonizing cells are poorly adapted for proliferation in the local tissue environment, so that cell death is more likely than cell division, i.e. θ < 1. We quantify the rare event statistics for the successful establishment of a metastatic colony of size N.

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    Date Created
    • 2014-08-01
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1088/1478-3975/11/4/046003
    • Identifier Type
      International standard serial number
      Identifier Value
      1478-3975
    • Identifier Type
      International standard serial number
      Identifier Value
      1478-3967

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    Cisneros, Luis H., & Newman, Timothy J. (2014). Quantifying metastatic inefficiency: rare genotypes versus rare dynamics. PHYSICAL BIOLOGY, 11(4), 046003. http://dx.doi.org/10.1088/1478-3975/11/4/046003

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