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A fundamental problem in computational biophysics is to deduce the function of a protein from the structure. Many biological macromolecules such as enzymes, molecular motors or membrane transport proteins perform

A fundamental problem in computational biophysics is to deduce the function of a protein from the structure. Many biological macromolecules such as enzymes, molecular motors or membrane transport proteins perform their function by cycling between multiple conformational states. Understanding such conformational transitions, which typically occur on the millisecond to second time scale, is central to understanding protein function.

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Date Created
  • 2013-11-30
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  • Text
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    Identifier
    • Digital object identifier: 10.1080/08927022.2014.919497
    • Identifier Type
      International standard serial number
      Identifier Value
      0892-7022
    • Identifier Type
      International standard serial number
      Identifier Value
      1029-0435
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    Seyler, Sean L., & Beckstein, Oliver (2014). Sampling large conformational transitions: adenylate kinase as a testing ground. MOLECULAR SIMULATION, 40(10), 855-877. http://dx.doi.org/10.1080/08927022.2014.919497

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