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Cancer cell invasion is a major component of metastasis and is responsible for extensive cell diffusion into and major destruction of tissues. Cells exhibit complex invasion modes, including a variety

Cancer cell invasion is a major component of metastasis and is responsible for extensive cell diffusion into and major destruction of tissues. Cells exhibit complex invasion modes, including a variety of collective behaviors. This phenomenon results in the structural heterogeneity of the extracellular matrix (ECM) in tissues. Here, we systematically investigated the environmental heterogeneity facilitating tumor cell invasion via a combination of in vitro cell migration experiments and computer simulations.

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    Date Created
    • 2015-02-23
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1371/journal.pone.0118058
    • Identifier Type
      International standard serial number
      Identifier Value
      1045-3830
    • Identifier Type
      International standard serial number
      Identifier Value
      1939-1560

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    Zhu, Jiangrui, Liang, Long, Jiao, Yang, & Liu, Liyu (2015). Enhanced Invasion of Metastatic Cancer Cells via Extracellular Matrix Interface. PLOS ONE, 10(2). http://dx.doi.org/10.1371/journal.pone.0118058

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