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Background: The current influenza vaccines are effective against seasonal influenza, but cannot be manufactured in a timely manner for a sudden pandemic or to be cost-effective to immunize huge flocks

Background: The current influenza vaccines are effective against seasonal influenza, but cannot be manufactured in a timely manner for a sudden pandemic or to be cost-effective to immunize huge flocks of birds. We propose a novel influenza vaccine composing a bacterial carrier and a plasmid cargo. In the immunized subjects, the bacterial carrier invades and releases its cargo into host cells where the plasmid expresses viral RNAs and proteins for reconstitution of attenuated influenza virus. Here we aimed to construct a mouse Poll-driven plasmid for efficient production of influenza virus.

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    Date Created
    • 2015-06-22
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1186/s12985-015-0321-5
    • Identifier Type
      International standard serial number
      Identifier Value
      1743-422X

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    Zhang, Xiangmin, & Curtiss, Roy, III (2015). Efficient generation of influenza virus with a mouse RNA polymerase I-driven all-in-one plasmid. VIROLOGY JOURNAL, 12. http://dx.doi.org/10.1186/s12985-015-0321-5

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