Cystatin C (CysC) is an endogenous cysteine protease inhibitor that can be used to assess the progression of kidney function. Recent studies demonstrate that CysC is a more specific indicator of glomerular filtration rate (GFR) than creatinine. CysC in plasma exists in multiple proteoforms. The goal of this study was to clarify the association of native CysC, CysC missing N-terminal Serine (CysC des-S), and CysC without three N-terminal residues (CysC des-SSP) with diabetic chronic kidney disease (CKD).
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- Digital object identifier: 10.1186/s12953-016-0096-7
- Identifier TypeInternational standard serial numberIdentifier Value1477-5956
- The electronic version of this article is the complete one and can be found online at: https://proteomesci.biomedcentral.com/articles/10.1186/s12953-016-0096-7, opens in a new window
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Yassine, H. N., Trenchevska, O., Dong, Z., Bashawri, Y., Koska, J., Reaven, P. D., . . . Nedelkov, D. (2016). The association of plasma cystatin C proteoforms with diabetic chronic kidney disease. Proteome Science, 14(1). doi:10.1186/s12953-016-0096-7