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Measurements on embryonic epithelial tissues in a diverse range of organisms have shown that the statistics of cell neighbor numbers are universal in tissues where cell proliferation is the primary

Measurements on embryonic epithelial tissues in a diverse range of organisms have shown that the statistics of cell neighbor numbers are universal in tissues where cell proliferation is the primary cell activity. Highly simplified non-spatial models of proliferation are claimed to accurately reproduce these statistics. Using a systematic critical analysis, we show that non-spatial models are not capable of robustly describing the universal statistics observed in proliferating epithelia, indicating strong spatial correlations between cells.

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    • 2011-04-29
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    Sandersius, S. A., Chuai, M., Weijer, C. J., & Newman, T. J. (2011). Correlating Cell Behavior with Tissue Topology in Embryonic Epithelia. PLoS ONE, 6(4). doi:10.1371/journal.pone.0018081

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