Extra-intestinal pathogenic E. coli (ExPEC), including avian pathogenic E. coli (APEC), pose a considerable threat to both human and animal health, with illness causing substantial economic loss. APEC strain χ7122 (O78∶K80∶H9), containing three large plasmids [pChi7122-1 (IncFIB/FIIA-FIC), pChi7122-2 (IncFII), and pChi7122-3 (IncI[subscript 2])]; and a small plasmid pChi7122-4 (ColE2-like), has been used for many years as a model strain to study the molecular mechanisms of ExPEC pathogenicity and zoonotic potential.
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- Mellata, Melha (Contributor)
- Maddux, Jacob (Contributor)
- Nam, Timothy (Contributor)
- Thomson, Nicholas (Author)
- Hauser, Heidi (Author)
- Stevens, Mark P. (Author)
- Mukhopadhyay, Suman (Author)
- Sarker, Shameema (Contributor)
- Crabbe, Aurelie (Contributor)
- Nickerson, Cheryl (Contributor)
- Santander, Javier (Contributor)
- Curtiss, Roy (Contributor)
- Immunotherapy, Vaccines and Virotherapy (Contributor)
- Biodesign Institute (Contributor)
- 2012-01-04
- Digital object identifier: 10.1371/journal.pone.0029481
- Identifier TypeInternational standard serial numberIdentifier Value1045-3830
- Identifier TypeInternational standard serial numberIdentifier Value1939-1560
- The article is published at http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029481, opens in a new window
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Mellata, M., Maddux, J. T., Nam, T., Thomson, N., Hauser, H., Stevens, M. P., . . . Curtiss, R. (2012). New Insights into the Bacterial Fitness-Associated Mechanisms Revealed by the Characterization of Large Plasmids of an Avian Pathogenic E. coli. PLoS ONE, 7(1). doi:10.1371/journal.pone.0029481