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This study presents the first global transcriptional profiling and phenotypic characterization of the major human opportunistic fungal pathogen, Candida albicans, grown in spaceflight conditions. Microarray analysis revealed that C. albicans

This study presents the first global transcriptional profiling and phenotypic characterization of the major human opportunistic fungal pathogen, Candida albicans, grown in spaceflight conditions. Microarray analysis revealed that C. albicans subjected to short-term spaceflight culture differentially regulated 452 genes compared to synchronous ground controls, which represented 8.3% of the analyzed ORFs. Spaceflight-cultured C. albicans–induced genes involved in cell aggregation (similar to flocculation), which was validated by microscopic and flow cytometry analysis.

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    Date Created
    • 2013-12-04
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1371/journal.pone.0080677
    • Identifier Type
      International standard serial number
      Identifier Value
      1045-3830
    • Identifier Type
      International standard serial number
      Identifier Value
      1939-1560

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    Crabbé, A., Nielsen-Preiss, S. M., Woolley, C. M., Barrila, J., Buchanan, K., Mccracken, J., . . . Nickerson, C. A. (2013). Spaceflight Enhances Cell Aggregation and Random Budding in Candida albicans. PLoS ONE, 8(12). doi:10.1371/journal.pone.0080677

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