Description

Positive allosteric modulators (PAMs) of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are a diverse class of compounds that increase fast excitatory transmission in the brain. AMPA PAMs have been shown to facilitate

Positive allosteric modulators (PAMs) of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are a diverse class of compounds that increase fast excitatory transmission in the brain. AMPA PAMs have been shown to facilitate long-term potentiation, strengthen communication between various cortical and subcortical regions, and some of these compounds increase the production and release of brain-derived neurotrophic factor (BDNF) in an activity-dependent manner.

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    Date Created
    • 2013-12-30
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.3390/ph7010029
    • Identifier Type
      International standard serial number
      Identifier Value
      1424-8247

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    Watterson, L., & Olive, M. (2013). Are AMPA Receptor Positive Allosteric Modulators Potential Pharmacotherapeutics for Addiction? Pharmaceuticals, 7(1), 29-45. doi:10.3390/ph7010029

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