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Glutamate plays a pivotal role in drug addiction, and the N-methyl-D-aspartate (NMDA) glutamate receptor subtype serves as a molecular target for several drugs of abuse. In this review, we will

Glutamate plays a pivotal role in drug addiction, and the N-methyl-D-aspartate (NMDA) glutamate receptor subtype serves as a molecular target for several drugs of abuse. In this review, we will provide an overview of NMDA receptor structure and function, followed by a review of the mechanism of action, clinical efficacy, and side effect profile of NMDA receptor ligands that are currently in use or being explored for the treatment of drug addiction. These ligands include the NMDA receptor modulators memantine and acamprosate, as well as the partial NMDA agonist D-cycloserine.

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    Date Created
    • 2013-02-06
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.3390/ph6020251
    • Identifier Type
      International standard serial number
      Identifier Value
      1424-8247

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    Tomek, S. E., LaCrosse, A. L., Nemirovsky, N. E., & Olive, M. F. (2013). NMDA Receptor Modulators in the Treatment of Drug Addiction. Pharmaceuticals, 6(2), 251-268. doi:10.3390/ph6020251

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