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Cervical cancer is the most common malignancy among women particularly in developing countries, with human papillomavirus (HPV) 16 causing 50% of invasive cervical cancers. A plant-based HPV vaccine is an

Cervical cancer is the most common malignancy among women particularly in developing countries, with human papillomavirus (HPV) 16 causing 50% of invasive cervical cancers. A plant-based HPV vaccine is an alternative to the currently available virus-like particle (VLP) vaccines, and would be much less expensive. We optimized methods to express HPV16 L1 protein and purify VLPs from tobacco (Nicotiana benthamiana) leaves transfected with the magnICON deconstructed viral vector expression system.

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    Date Created
    • 2016-08-12
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1371/journal.pone.0160995
    • Identifier Type
      International standard serial number
      Identifier Value
      1045-3830
    • Identifier Type
      International standard serial number
      Identifier Value
      1939-1560

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    Zahin, M., Joh, J., Khanal, S., Husk, A., Mason, H., Warzecha, H., . . . Jenson, A. B. (2016). Scalable Production of HPV16 L1 Protein and VLPs from Tobacco Leaves. Plos One, 11(8). doi:10.1371/journal.pone.0160995

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