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  4. Whole Genome Sequencing of Field Isolates Reveals Extensive Genetic Diversity in Plasmodium Vivax From Colombia
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Whole Genome Sequencing of Field Isolates Reveals Extensive Genetic Diversity in Plasmodium Vivax From Colombia

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Description

Plasmodium vivax is the most prevalent malarial species in South America and exerts a substantial burden on the populations it affects. The control and eventual elimination of P. vivax are global health priorities. Genomic research contributes to this objective by improving our understanding of the biology of P. vivax and through the development of new genetic markers that can be used to monitor efforts to reduce malaria transmission. Here we analyze whole-genome data from eight field samples from a region in Cordóba, Colombia where malaria is endemic. We find considerable genetic diversity within this population, a result that contrasts with earlier studies suggesting that P. vivax had limited diversity in the Americas. We also identify a selective sweep around a substitution known to confer resistance to sulphadoxine-pyrimethamine (SP). This is the first observation of a selective sweep for SP resistance in this species. These results indicate that P. vivax has been exposed to SP pressure even when the drug is not in use as a first line treatment for patients afflicted by this parasite. We identify multiple non-synonymous substitutions in three other genes known to be involved with drug resistance in Plasmodium species. Finally, we found extensive microsatellite polymorphisms. Using this information we developed 18 polymorphic and easy to score microsatellite loci that can be used in epidemiological investigations in South America.

Date Created
2015-12-28
Contributors
  • Winter, David (Author)
  • Pacheco, Maria Andreina (Author)
  • Vallejo, Andres F. (Author)
  • Schwartz, Rachel (Author)
  • Arevalo-Herrera, Myriam (Author)
  • Herrera, Socrates (Author)
  • Cartwright, Reed (Author)
  • Escalante, Ananias (Author)
  • Biodesign Institute (Contributor)
Resource Type
Text
Extent
21 pages
Language
eng
Copyright Statement
In Copyright
Reuse Permissions
Attribution
Primary Member of
ASU Scholarship Showcase
Identifier
Digital object identifier: 10.1371/journal.pntd.0004252
Identifier Type
International standard serial number
Identifier Value
1935-2727
Identifier Type
International standard serial number
Identifier Value
1935-2735
Peer-reviewed
No
Open Access
No
Series
PLOS NEGLECTED TROPICAL DISEASES
Handle
https://hdl.handle.net/2286/R.I.43782
Preferred Citation

Winter, D. J., Pacheco, M. A., Vallejo, A. F., Schwartz, R. S., Arevalo-Herrera, M., Herrera, S., . . . Escalante, A. A. (2015). Whole Genome Sequencing of Field Isolates Reveals Extensive Genetic Diversity in Plasmodium vivax from Colombia. PLOS Neglected Tropical Diseases, 9(12). doi:10.1371/journal.pntd.0004252

Level of coding
minimal
Cataloging Standards
asu1
Note
The article is published at http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0004252, opens in a new window
System Created
  • 2017-05-22 03:56:43
System Modified
  • 2021-12-10 05:08:41
  •     
  • 1 year 3 months ago
Additional Formats
  • OAI Dublin Core
  • MODS XML

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