The heterocyclic indole-alkaloid scytonemin is a sunscreen found exclusively among cyanobacteria. An 18-gene cluster is responsible for scytonemin production in Nostoc punctiforme ATCC 29133. The upstream genes scyABCDEF in the cluster are proposed to be responsible for scytonemin biosynthesis from aromatic amino acid substrates. In vitro studies of ScyA, ScyB, and ScyC proved that these enzymes indeed catalyze initial pathway reactions.
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- Ferreira, Daniela (Contributor)
- Garcia-Pichel, Ferran (Contributor)
- College of Liberal Arts and Sciences (Contributor)
- 2016-05-18
- Digital object identifier: 10.3389/fmicb.2016.00735
- Identifier TypeInternational standard serial numberIdentifier Value1664-1078
- View the article as published at http://journal.frontiersin.org/article/10.3389/fmicb.2016.00735/full, opens in a new window
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Ferreira, D., & Garcia-Pichel, F. (2016). Mutational Studies of Putative Biosynthetic Genes for the Cyanobacterial Sunscreen Scytonemin in Nostoc punctiforme ATCC 29133. Frontiers in Microbiology, 7. doi:10.3389/fmicb.2016.00735