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Surveillance of Barrett’s oesophagus allows us to study the evolutionary dynamics of a human neoplasm over time. Here we use multicolour fluorescence in situ hybridization on brush cytology specimens, from

Surveillance of Barrett’s oesophagus allows us to study the evolutionary dynamics of a human neoplasm over time. Here we use multicolour fluorescence in situ hybridization on brush cytology specimens, from two time points with a median interval of 37 months in 195 non-dysplastic Barrett's patients, and a third time point in a subset of 90 patients at a median interval of 36 months, to study clonal evolution at single-cell resolution. Baseline genetic diversity predicts progression and remains in a stable dynamic equilibrium over time.

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    Date Created
    • 2016-08-19
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    Identifier
    • Digital object identifier: 10.1038/ncomms12158
    • Identifier Type
      International standard serial number
      Identifier Value
      2041-1723
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    Martinez, P., Timmer, M. R., Lau, C. T., Calpe, S., Sancho-Serra, M. D., Straub, D., . . . Krishnadath, K. K. (2016). Dynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus. Nature Communications, 7, 12158. doi:10.1038/ncomms12158

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