Surveillance of Barrett’s oesophagus allows us to study the evolutionary dynamics of a human neoplasm over time. Here we use multicolour fluorescence in situ hybridization on brush cytology specimens, from two time points with a median interval of 37 months in 195 non-dysplastic Barrett's patients, and a third time point in a subset of 90 patients at a median interval of 36 months, to study clonal evolution at single-cell resolution. Baseline genetic diversity predicts progression and remains in a stable dynamic equilibrium over time.
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- Martinez, Pierre (Author)
- Timmer, Margriet R. (Author)
- Lau, Chiu T. (Author)
- Calpe, Silvia (Author)
- del Carmen Sancho-Serra, Maria (Author)
- Straub, Danielle (Author)
- Baker, Ann-Marie (Author)
- Meijer, Sybren L. (Author)
- ten Kate, Fiebo J. W. (Author)
- Mallant-Hent, Rosalie C. (Author)
- Naber, Anton H. J. (Author)
- van Oijen, Arnoud H. A. M. (Author)
- Baak, Lubbertus C. (Author)
- Scholten, Pieter (Author)
- Bohmer, Clarisse J. M. (Author)
- Fockens, Paul (Author)
- Bergman, Jacques J. G. H. M. (Author)
- Maley, Carlo (Contributor)
- Graham, Trevor A. (Author)
- Krishnadath, Kausilia K. (Author)
- Biodesign Institute (Contributor)
- 2016-08-19
- Digital object identifier: 10.1038/ncomms12158
- Identifier TypeInternational standard serial numberIdentifier Value2041-1723
- The final version of this article, as published in Nature Communications, can be viewed online at: https://www.nature.com/articles/ncomms12158, opens in a new window
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Martinez, P., Timmer, M. R., Lau, C. T., Calpe, S., Sancho-Serra, M. D., Straub, D., . . . Krishnadath, K. K. (2016). Dynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus. Nature Communications, 7, 12158. doi:10.1038/ncomms12158