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It has long been accepted that modern reproductive patterns are likely contributors to breast cancer susceptibility because of their influence on hormones such as estrogen and the importance of these

It has long been accepted that modern reproductive patterns are likely contributors to breast cancer susceptibility because of their influence on hormones such as estrogen and the importance of these hormones in breast cancer. We conducted a meta-analysis to assess whether this ‘evolutionary mismatch hypothesis’ can explain susceptibility to both estrogen receptor positive (ER-positive) and estrogen receptor negative (ER-negative) cancer. Our meta-analysis includes a total of 33 studies and examines parity, age of first birth and age of menarche broken down by estrogen receptor status.

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    Date Created
    • 2014-11-11
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1093/emph/eou028
    • Identifier Type
      International standard serial number
      Identifier Value
      2050-6201
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    Aktipis, C. A., Ellis, B. J., Nishimura, K. K., & Hiatt, R. A. (2014). Modern reproductive patterns associated with estrogen receptor positive but not negative breast cancer susceptibility. Evolution, Medicine, and Public Health, 2015(1), 52-74. doi:10.1093/emph/eou028

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