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Telomeres are repetitive DNA sequences at linear chromosome termini, protecting chromosomes against end-to-end fusion and damage, providing chromosomal stability. Telomeres shorten with mitotic cellular division, but are maintained in cells

Telomeres are repetitive DNA sequences at linear chromosome termini, protecting chromosomes against end-to-end fusion and damage, providing chromosomal stability. Telomeres shorten with mitotic cellular division, but are maintained in cells with high proliferative capacity by telomerase. Loss-of-function mutations in telomere-maintenance genes are genetic risk factors for cirrhosis development in humans and murine models. Telomerase deficiency provokes accelerated telomere shortening and dysfunction, facilitating genomic instability and oncogenesis.

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    Date Created
    • 2017-08-16
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1371/journal.pone.0183287
    • Identifier Type
      International standard serial number
      Identifier Value
      1045-3830
    • Identifier Type
      International standard serial number
      Identifier Value
      1939-1560

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    Donaires, F. S., Scatena, N. F., Alves-Paiva, R. M., Podlevsky, J. D., Logeswaran, D., Santana, B. A., . . . Martinelli, A. L. (2017). Telomere biology and telomerase mutations in cirrhotic patients with hepatocellular carcinoma. Plos One, 12(8). doi:10.1371/journal.pone.0183287

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