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α-(1,3)-Glucan is a major component of the cell wall of Aspergillus fumigatus, an opportunistic human fungal pathogen. There are three genes (AGS1, AGS2 and AGS3) controlling the biosynthesis of α-(1,3)-glucan

α-(1,3)-Glucan is a major component of the cell wall of Aspergillus fumigatus, an opportunistic human fungal pathogen. There are three genes (AGS1, AGS2 and AGS3) controlling the biosynthesis of α-(1,3)-glucan in this fungal species. Deletion of all the three AGS genes resulted in a triple mutant that was devoid of α-(1,3)-glucan in its cell wall; however, its growth and germination was identical to that of the parental strain in vitro. In the experimental murine aspergillosis model, this mutant was less pathogenic than the parental strain.

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    Date Created
    • 2013-11-14
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  • Text
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    Identifier
    • Digital object identifier: 10.1371/journal.ppat.1003716
    • Identifier Type
      International standard serial number
      Identifier Value
      1553-7366
    • Identifier Type
      International standard serial number
      Identifier Value
      1553-7374

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    Beauvais, A., Bozza, S., Kniemeyer, O., Formosa, C., Balloy, V., Henry, C., . . . Latgé, J. (2013). Deletion of the α-(1,3)-Glucan Synthase Genes Induces a Restructuring of the Conidial Cell Wall Responsible for the Avirulence of Aspergillus fumigatus. PLoS Pathogens, 9(11). doi:10.1371/journal.ppat.1003716

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