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Alpha herpesvirus genomes encode the capacity to establish quiescent infections (i.e. latency) in the peripheral nervous system for the life of their hosts. Multiple times during latency, viral genomes can

Alpha herpesvirus genomes encode the capacity to establish quiescent infections (i.e. latency) in the peripheral nervous system for the life of their hosts. Multiple times during latency, viral genomes can reactivate to start a productive infection, enabling spread of progeny virions to other hosts. Replication of alpha herpesviruses is well studied in cultured cells and many aspects of productive replication have been identified. However, many questions remain concerning how a productive or a quiescent infection is established.

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    Date Created
    • 2017-10-26
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  • Text
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    Identifier
    • Digital object identifier: 10.1371/journal.ppat.1006608
    • Identifier Type
      International standard serial number
      Identifier Value
      1553-7366
    • Identifier Type
      International standard serial number
      Identifier Value
      1553-7374

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    Koyuncu, O. O., Macgibeny, M. A., Hogue, I. B., & Enquist, L. W. (2017). Compartmented neuronal cultures reveal two distinct mechanisms for alpha herpesvirus escape from genome silencing. PLOS Pathogens, 13(10). doi:10.1371/journal.ppat.1006608

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