Faculty and Staff

Five immunocompetent C57BL/6-cBrd/cBrd/Cr (albino C57BL/6) mice were injected with GL261-luc2 cells, a cell line sharing characteristics of human glioblastoma multiforme (GBM). The mice were imaged using magnetic resonance (MR) at five separate time points to characterize growth and development of the tumor. After 25 days, the final tumor volumes of the mice varied from 12 mm³ to 62 mm³, even though mice were inoculated from the same tumor cell line under carefully controlled conditions. We generated hypotheses to explore large variances in final tumor size and tested them with our simple reaction-diffusion model in both a 3-dimensional (3D) finite difference method and a 2-dimensional (2D) level set method. The parameters obtained from a best-fit procedure, designed to yield simulated tumors as close as possible to the observed ones, vary by an order of magnitude between the three mice analyzed in detail. These differences may reflect morphological and biological variability in tumor growth, as well as errors in the mathematical model, perhaps from an oversimplification of the tumor dynamics or nonidentifiability of parameters. Our results generate parameters that match other experimental in vitro and in vivo measurements. Additionally, we calculate wave speed, which matches with other rat and human measurements.

Background:
Data assimilation refers to methods for updating the state vector (initial condition) of a complex spatiotemporal model (such as a numerical weather model) by combining new observations with one or more prior forecasts. We consider the potential feasibility of this approach for making short-term (60-day) forecasts of the growth and spread of a malignant brain cancer (glioblastoma multiforme) in individual patient cases, where the observations are synthetic magnetic resonance images of a hypothetical tumor.

Results:
We apply a modern state estimation algorithm (the Local Ensemble Transform Kalman Filter), previously developed for numerical weather prediction, to two different mathematical models of glioblastoma, taking into account likely errors in model parameters and measurement uncertainties in magnetic resonance imaging. The filter can accurately shadow the growth of a representative synthetic tumor for 360 days (six 60-day forecast/update cycles) in the presence of a moderate degree of systematic model error and measurement noise.

Conclusions:
The mathematical methodology described here may prove useful for other modeling efforts in biology and oncology. An accurate forecast system for glioblastoma may prove useful in clinical settings for treatment planning and patient counseling.

Although they have distinct missions, public libraries and academic libraries serve overlapping populations and can leverage their institutional strengths through collaboration. These diverse partnerships include sharing resources through consortia, joint-use libraries, and shared programming, such as introducing students to public library collections as resources for theses. For the scholarly communication librarian, collaborating with public libraries provides opportunities to educate about the ethical and legal use of information, advocate for the promotion and use of open resources and pedagogies, and interact with communities, particularly in rural areas, that are traditionally underserved by academic libraries. We’ll share two personal examples of the intersection between scholarly communication and public libraries.

In this case study, we reflect on our journey through a major revision of our streaming video reserve guidelines, informed by an environmental scan of comparable library services and current copyright best practices. Once the guidelines were revised, we developed an implementation plan for communicating changes and developing training materials to both instructors and internal library staff. We share our navigation strategies, obstacles faced, lessons learned, and ongoing challenges. Finally, we map out some of our future directions for improving and streamlining our services.

Purpose: In spring of 2007, Arizona State University Libraries held a focus group of selected faculty to discover their perceptions and use of electronic books (e-books) in their research and teaching.

Methodology/approach: We employed the services of the Institute of Social Sciences Research to recruit and moderate the focus group. The following major themes were explored:
       1) Use of e-books as textbooks.
       2) Use of e-books for personal research.
       3) Comparison between e-books and print.
       4) Disciplinary differences in perceptions of e-books.
       5) Motivators for future use

Findings: Overall, the focus group revealed that faculty had generally unsatisfactory experiences in using e-books in their research and teaching due to the unreliability of access, lack of manipulability, and the steep learning curve of the various interfaces. However, most faculty agreed that e-books would be a very viable and useful alternative if these issues were resolved.

Research limitations/implications: The focus group consisted of only six faculty members and hence is not representative of faculty as a whole. A larger survey of a more diverse faculty population would greatly serve to clarify and expand upon our findings.

Practical implications: The implications for academic libraries include providing better outreach and training to faculty about the e-book platforms offered, provide better course support, and advocate to e-book vendors to consider faculty's teaching and research needs in their product development.

Originality/value of paper: To the best knowledge of the authors, this is the first published study of faculty opinions and use of e-books utilizing focus group methodology and offers detailed information that would be useful for academic libraries and e-book vendors for evidence-based decisions.

Videos are a useful and popular way to reach an audience — we all know videos that have gone viral online, garnering millions of views. However, the type of video that can compete with Old Spice commercials takes weeks to plan and produce, as well as a significant budget. Arizona State University (ASU) Libraries wanted to find a sustainable way to share videos that would require minimal staff time to create and produce.

With that goal in mind, “The Library Minute” was born. We initially envisioned a weekly newscast, but it has evolved into a successful and fun video series. Episodes have been featured in American Libraries Direct, as part of the ACRL Marketing Minute, received more than 74,000 views on YouTube and the Internet Archive, and have garnered complimentary e-mails from all over the world. Most importantly, they are a valuable marketing and outreach tool for the ASU Libraries and have increased our visibility to our students and other departments in the university.