Faculty and Staff

(Preprint.) Today's college and university learning landscapes are dynamic and
characterized by increased student demand for highly flexible and self-paced online learning opportunities. Recent fiscal conditions in higher education make learning landscape development more challenging due to finite resources and competing priorities. Similarly, academic libraries are experiencing substantial budget and staff reductions. Despite these trends, academic libraries are in a strong position to contribute to surrounding learning landscapes by expanding student online learning opportunities and promoting the critical use of information. Evolving learning technologies available for free or at low cost provide higher education and libraries with the tools to respond to this fluid environment.

Leveraging Drupal for your business:
Use Drupal to power your business -- hear case studies and learn about adapting to open-source technology.

Libraries are growing into new joint entities -- the library as a place, and the library as a resource. Library websites serve as a resource, delivering tools for learning to patrons and students in an academic setting. Drupal is an ideal tool for facilitating the specialized tasks that many library developers have to complete.

In this session, attendees will learn about:
       1. Using the built-in architecture of Drupal 6 and Drupal 7 to meet the goals of library 
           websites.
       2. The 10 best modules for library websites.
       3. 10 recommended theming techniques for common library interfaces.
       4. New expectations of library websites as gathered from user surveys and usability
           studies.
       5. Example set-ups of Drupal sites for common library settings and staff organizations.
       6. Successful case studies of major library websites run on Drupal.
       7. Tips for useful library-specific usability studies with library users and students.

Attendees will come away from this session with a firm understanding of quality library sites as tools, and what many users are growing to expect. They will also learn how to set up a Drupal website for a library, and successful ways to meet the specific resource needs of their organizations.

The archived event website can be accessed here.

The threat of West Nile virus (WNV) epidemics with increasingly severe neuroinvasive infections demands the development and licensing of effective vaccines. To date, vaccine candidates based on inactivated, live-attenuated, or chimeric virus, and viral DNA and WNV protein subunits have been developed. Some have been approved for veterinary use or are under clinical investigation, yet no vaccine has been licensed for human use. Reaching the milestone of a commercialized human vaccine, however, may largely depend on the economics of vaccine production. Analysis suggests that currently only novel low-cost production technologies would allow vaccination to outcompete the cost of surveillance and clinical treatment. Here, we review progress using plants to address the economic challenges of WNV vaccine production. The advantages of plants as hosts for vaccine production in cost, speed and scalability, especially those of viral vector-based transient expression systems, are discussed. The progress in developing WNV subunit vaccines in plants is reviewed within the context of their expression, characterization, downstream processing, and immunogenicity in animal models. The development of vaccines based on enveloped and non-enveloped virus-like particles is also discussed. These advancements suggest that plants may provide a production platform that offers potent, safe and affordable human vaccines against WNV.

Osteosarcoma is the most common bone cancer in children and adolescents. Although 70% of patients with localized disease are cured with chemotherapy and surgical resection, patients with metastatic osteosarcoma are typically refractory to treatment. Numerous lines of evidence suggest that cytotoxic T lymphocytes (CTLs) limit the development of metastatic osteosarcoma. We have investigated the role of PD-1, an inhibitory TNFR family protein expressed on CTLs, in limiting the efficacy of immune-mediated control of metastatic osteosarcoma. We show that human metastatic, but not primary, osteosarcoma tumors express a ligand for PD-1 (PD-L1) and that tumor-infiltrating CTLs express PD-1, suggesting this pathway may limit CTLs control of metastatic osteosarcoma in patients. PD-L1 is also expressed on the K7M2 osteosarcoma tumor cell line that establishes metastases in mice, and PD-1 is expressed on tumor-infiltrating CTLs during disease progression. Blockade of PD-1/PD-L1 interactions dramatically improves the function of osteosarcoma-reactive CTLs in vitro and in vivo, and results in decreased tumor burden and increased survival in the K7M2 mouse model of metastatic osteosarcoma. Our results suggest that blockade of PD-1/PD-L1 interactions in patients with metastatic osteosarcoma should be pursued as a therapeutic strategy.

Limited to streaming only those videos a vendor hosted, ASU Libraries sought to expand collection options with a trial project for hosting content locally. Kaltura, was selected as the platform, but Kaltura does not work out of the box. This presentation will cover how using Drupal, along with Kaltura, we built a working video hosting solution. The presentation will cover administrative hurdles, stumbling blocks, pitfalls, enhancements, and lessons learned along the way.