ASU Electronic Theses and Dissertations
This collection includes most of the ASU Theses and Dissertations from 2011 to present. ASU Theses and Dissertations are available in downloadable PDF format; however, a small percentage of items are under embargo. Information about the dissertations/theses includes degree information, committee members, an abstract, supporting data or media.
In addition to the electronic theses found in the ASU Digital Repository, ASU Theses and Dissertations can be found in the ASU Library Catalog.
Dissertations and Theses granted by Arizona State University are archived and made available through a joint effort of the ASU Graduate College and the ASU Libraries. For more information or questions about this collection contact or visit the Digital Repository ETD Library Guide or contact the ASU Graduate College at gradformat@asu.edu.
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- Genre: Doctoral Dissertation
This research study focuses on the behavior of crystalline silicon PV module technology in the dry and hot climatic condition of Tempe/Phoenix, Arizona. A three-phase approach was developed: (1) A quantitative failure modes, effects, and criticality analysis (FMECA) was developed for prioritizing failure modes or mechanisms in a given environment; (2) A time-series approach was used to model environmental stress variables involved and prioritize their effect on the power output drop; and (3) A procedure for developing a prediction model was proposed for the climatic specific condition based on accelerated degradation testing
As part of this dissertation, a yield approximation method is developed and integrated with a mixed-integer program to estimate a region’s potential to produce non-perennial, vegetable items. This integration offers practical approximations that help decision-makers identify technologies needed to protect agricultural production, alter harvesting patterns to better match market behavior, and provide an analytical framework through which external investment entities can assess different production options.
This research first investigates the maintenance scheduling in transportation networks with service vehicles (e.g., truck fleets and passenger transport fleets), where these vehicles are assumed to take the system-optimized routes that minimize the total travel cost of the fleet. This problem is solved with the randomized fixed-and-optimize heuristic developed. This research also investigates the maintenance scheduling in networks with multi-modal traffic that consists of (1) regular human-driven cars with user-optimized routing and (2) self-driving vehicles with system-optimized routing. An iterative mixed flow assignment algorithm is developed to obtain the multi-modal traffic assignment resulting from a maintenance schedule. The genetic algorithm with multi-point crossover is applied to obtain a good schedule.
Based on the Braess’ paradox that removing some links may alleviate the congestion of user-optimized flows, this research generalizes the Braess’ paradox to reduce the capacity of selected links to improve the efficiency of the resultant user-optimized flows. A heuristic is developed to identify links to reduce capacity, and the corresponding capacity reduction amounts, to get more efficient total flows. Experiments on real networks demonstrate the generalized Braess’ paradox exists in reality, and the heuristic developed solves real-world test cases even when commercial solvers fail.
innovation in healthcare policy over a huge variety of applications by tackling prob-
lems via the creation and optimization of descriptive mathematical models to guide
decision-making. Despite these accomplishments, models are stylized representations
of real-world applications, reliant on accurate estimations from historical data to jus-
tify their underlying assumptions. To protect against unreliable estimations which
can adversely affect the decisions generated from applications dependent on fully-
realized models, techniques that are robust against misspecications are utilized while
still making use of incoming data for learning. Hence, new robust techniques are ap-
plied that (1) allow for the decision-maker to express a spectrum of pessimism against
model uncertainties while (2) still utilizing incoming data for learning. Two main ap-
plications are investigated with respect to these goals, the first being a percentile
optimization technique with respect to a multi-class queueing system for application
in hospital Emergency Departments. The second studies the use of robust forecasting
techniques in improving developing countries’ vaccine supply chains via (1) an inno-
vative outside of cold chain policy and (2) a district-managed approach to inventory
control. Both of these research application areas utilize data-driven approaches that
feature learning and pessimism-controlled robustness.
The first topic is diagnosis/subtyping of migraine to customize effective treatment to different subtypes of patients. Existing clinical definitions of subtypes use somewhat arbitrary boundaries primarily based on patient self-reported symptoms, which are subjective and error-prone. My research develops a novel Multimodality Factor Mixture Model that discovers subtypes of migraine from multimodality imaging MRI data, which provides complementary accurate measurements of the disease. Patients in the different subtypes show significantly different clinical characteristics of the disease. Treatment tailored and optimized for patients of the same subtype paves the road toward Precision Medicine.
The second topic focuses on coordinated patient care. Care coordination between nurses and with other health care team members is important for providing high-quality and efficient care to patients. The recently developed Nurse Care Coordination Instrument (NCCI) is the first of its kind that enables large-scale quantitative data to be collected. My research develops a novel Multi-response Multi-level Model (M3) that enables transfer learning in NCCI data fusion. M3 identifies key factors that contribute to improving care coordination, and facilitates the design and optimization of nurses’ training, workload assignment, and practice environment, which leads to improved patient outcomes.
The last topic is about system-level decision-making for Alzheimer’s disease early detection at the early stage of Mild Cognitive Impairment (MCI), by predicting each MCI patient’s risk of converting to AD using imaging and proteomic biomarkers. My research proposes a systems engineering approach that integrates the multi-perspectives, including prediction accuracy, biomarker cost/availability, patient heterogeneity and diagnostic efficiency, and allows for system-wide optimized decision regarding the biomarker testing process for prediction of MCI conversion.
The reliability structure uncertainty cannot be handled by the traditional relia- bility analysis tools such as Fault Tree and Reliability Block Diagram due to their deterministic Boolean logic. Therefore, I employ Bayesian network that provides a flexible modeling method for building a multivariate distribution. By representing a system reliability structure as a joint distribution, the uncertainty and correlations existing between system’s elements can effectively be modeled in a probabilistic man- ner. This dissertation focuses on analyzing system reliability for the entire system life cycle, particularly, production stage and early design stages.
In production stage, the research investigates a system that is continuously mon- itored by on-board sensors. With modeling the complex reliability structure by Bayesian network integrated with various stochastic processes, I propose several methodologies that evaluate system reliability on real-time basis and optimize main- tenance schedules.
In early design stages, the research aims to predict system reliability based on the current system design and to improve the design if necessary. The three main challenges in this research are: 1) the lack of field failure data, 2) the complex reliability structure and 3) how to effectively improve the design. To tackle the difficulties, I present several modeling approaches using Bayesian inference and nonparametric Bayesian network where the system is explicitly analyzed through the sensitivity analysis. In addition, this modeling approach is enhanced by incorporating a temporal dimension. However, the nonparametric Bayesian network approach generally accompanies with high computational efforts, especially, when a complex and large system is modeled. To alleviate this computational burden, I also suggest to building a surrogate model with quantile regression.
In summary, this dissertation studies and explores the use of Bayesian network in analyzing complex systems. All proposed methodologies are demonstrated by case studies.
Topic 1: Design of super-HIS and tracking of quality of care (QoC). My research developed an information technology that integrates multiple HISs in radiology, and proposed QoC metrics defined upon the data that measure various dimensions of care. The DDD assisted the clinical practices and enabled an effective intervention for reducing lengthy radiologist turnaround times for patients.
Topic 2: Monitoring and change detection of QoC data streams for process improvement. With the super-HIS in place, high-dimensional data streams of QoC metrics are generated. I developed a statistical model for monitoring high- dimensional data streams that integrated Singular Vector Decomposition (SVD) and process control. The algorithm was applied to QoC metrics data, and additionally extended to another application of monitoring traffic data in communication networks.
Topic 3: Deep transfer learning of archive HIS data for computer-aided diagnosis (CAD). The novelty of the CAD system is the development of a deep transfer learning algorithm that combines the ideas of transfer learning and multi- modality image integration under the deep learning framework. Our system achieved high accuracy in breast cancer diagnosis compared with conventional machine learning algorithms.
The first topic is a Mixed Effects Transfer Learning (METL) model that can flexibly incorporate mixed effects and a general-form covariance matrix to better account for similarity and heterogeneity across subjects. I further develop computationally efficient procedures to handle unknown parameters and large covariance structures. Domain relations, such as domain similarity and domain covariance structure, are automatically quantified in the estimation steps. I demonstrate METL in an application of smartphone-based telemonitoring of PD.
The second topic focuses on an MRI-based transfer learning algorithm for non-invasive surgical guidance of glioblastoma patients. Limited biopsy samples per patient create a challenge to build a patient-specific model for glioblastoma. A transfer learning framework helps to leverage other patient’s knowledge for building a better predictive model. When modeling a target patient, not every patient’s information is helpful. Deciding the subset of other patients from which to transfer information to the modeling of the target patient is an important task to build an accurate predictive model. I define the subset of “transferrable” patients as those who have a positive rCBV-cell density correlation, because a positive correlation is confirmed by imaging theory and the its respective literature.
The last topic is a Privacy-Preserving Positive Transfer Learning (P3TL) model. Although negative transfer has been recognized as an important issue by the transfer learning research community, there is a lack of theoretical studies in evaluating the risk of negative transfer for a transfer learning method and identifying what causes the negative transfer. My work addresses this issue. Driven by the theoretical insights, I extend Bayesian Parameter Transfer (BPT) to a new method, i.e., P3TL. The unique features of P3TL include intelligent selection of patients to transfer in order to avoid negative transfer and maintain patient privacy. These features make P3TL an excellent model for telemonitoring of PD using an At-Home Testing Device.