ASU Electronic Theses and Dissertations

The phycologist, M. R. Droop, studied vitamin B12 limitation in the flagellate Monochrysis lutheri and concluded that its specific growth rate depended on the concentration of the vitamin within the cell; i.e. the cell quota of the vitamin B12. The Droop model provides a mathematical expression to link growth rate to the intracellular concentration of a limiting nutrient. Although the Droop model has been an important modeling tool in ecology, it has only recently been applied to study cancer biology. Cancer cells live in an ecological setting, interacting and competing with normal and other cancerous cells for nutrients and space, and evolving and adapting to their environment. Here, the Droop equation is used to model three cancers.

First, prostate cancer is modeled, where androgen is considered the limiting nutrient since most tumors depend on androgen for proliferation and survival. The model's accuracy for predicting the biomarker for patients on intermittent androgen deprivation therapy is tested by comparing the simulation results to clinical data as well as to an existing simpler model. The results suggest that a simpler model may be more beneficial for a predictive use, although further research is needed in this field prior to implementing mathematical models as a predictive method in a clinical setting.

Next, two chronic myeloid leukemia models are compared that consider Imatinib treatment, a drug that inhibits the constitutively active tyrosine kinase BCR-ABL. Both models describe the competition of leukemic and normal cells, however the first model also describes intracellular dynamics by considering BCR-ABL as the limiting nutrient. Using clinical data, the differences in estimated parameters between the models and the capacity for each model to predict drug resistance are analyzed.

Last, a simple model is presented that considers ovarian tumor growth and tumor induced angiogenesis, subject to on and off anti-angiogenesis treatment. In this environment, the cell quota represents the intracellular concentration of necessary nutrients provided through blood supply. Mathematical analysis of the model is presented and model simulation results are compared to pre-clinical data. This simple model is able to fit both on- and off-treatment data using the same biologically relevant parameters.

Beginning in the late 20th century, Spanish writers have shown great concern for matters relating to the Spanish Civil War (1936-39) and its aftermath. In narratives, they reveal, explicitly or implicitly, hidden events covered by the Franco dictatorship (1939-75). This persistence in their works about the past has been examined as necessary to society in overcoming the terrible events that occurred during the Franco's regime. Also, these narratives stand as a loud voice against impunity regarding crimes committed for almost half a century and the actual ongoing denial of the State to investigate, in depth, the crimes carried out in the past. Within this denial of the State, the disappearance of children took place during the postwar up until the first democratic government, established in 1978.

The objective of this research is to show, via fiction, the oppression and the manipulation of women during the Francoist period through different institutions, among them, Sección Femenina. Also, this study aims to prove that the separation of children from Republican mothers during the dictatorship, and later on from single poor mothers during the early years of the first democracy, was in violation of both the maternity rights of women and the children's rights. This investigation focuses on the novels Mala gente que camina (2006) by Benjamín Prado, Si a los tres años no he vuelto (2011) by Ana R. Cañil and Mientras pueda pensarte (2013) by Inmaculada Chacón. These literary works contest the stealing of children as a legitimized action with the appearance of goodness. The theoretical approaches selected for this study are: the abjection concept of Julia Kristeva, the hegemonic ideology of Antonio Gramsci; and lastly, the legalization of punishment of Michel Foucault.

The originality of this research as thesis lies to shine a light on the novels mentioned above as the evidence of the violation of the rights of motherhood and the biological family as a whole during the Franco dictatorship and again later during the early stages of Spanish democracy.

Research was conducted to observe the effect of Number of Transparent Covers and Refractive Index on performance of a domestic Solar Water heating system. The enhancement of efficiency for solar thermal system is an emerging challenge. The knowledge gained from this research will enable to optimize the number of transparent covers and refractive index prior to develop a solar water heater with improved optical efficiency and thermal efficiency for the collector. Numerical simulation is conducted on the performance of the liquid flat plate collector for July 21st and October 21st from 8 am to 4 pm with different refractive index values 1.1, 1.4, 1.7 and different numbers of transparent covers (0-3). In order to accomplish the proposed method the formulation and solutions are executed using simple software MATLAB. The result demonstrates efficiency of flat plate collector increases with the increase of number of covers. The performance of collector decreases when refractive index is higher. The improved useful heat gain is obtained when number of cover used is 3 and refractive index is 1.1.

"Linked Together" is a choreographic piece inspired by at-risk youth and their ability to learn, grow, and transform their lives through dance. The idea for the piece originated from dance programs implemented with under-resourced populations in Virginia, Panama, and India. My teaching experiences in these places sparked the development of a longer, more comprehensive dance program in Arizona, with a Boys and Girls Club. The Arizona dance program included specific somatics exercises, focused on the integration of mind and body, as well as other types of improvisations, to help the participants learn about movement concepts and develop original movement.

The title "Linked Together" suggests that all people are connected in many ways, regardless of personal differences such as socioeconomic status or language. The dancers included myself, Arizona State University (ASU) dance students, as well as Boys and Girls Club dance program participants. For the concert, all dancers portrayed stories and concepts related to empowerment through emotionally charged movement, and thereby provided audience members with a visceral lens through which to see the transformative powers of dance. The data collected from this project through observations, surveys, and interviews suggest that constructive behaviors that are internalized through dance can flow seamlessly into the non-dance world, encouraging people to think creatively, collaborate with others, gain a sense of ownership, and feel empowered in all parts of life.

Postwar suburban sprawl resulted in environmental consequences that engendered backlash from those concerned about the quality life in the places they lived, played, and worked. Few cities grew as rapidly as Phoenix and therefore the city offers an important case study to evaluate the success and limits of environmentalism in shaping urban growth in the postwar period.

Using three episodes looking at sanitation and public health, open space preservation, and urban transportation, I argue three factors played a critical role in determining the extent to which environmental values were incorporated into Phoenix's urban growth policy. First, the degree to which environmental values influenced urban policy depends on the degree to which they fit into the Southwestern suburban lifestyle. A desire for low-density development and quality of life amenities like outdoor recreation resulted in decisions to extend municipal sewers further into the desert, the creation of a mountain preserve system, and freeways as the primary mode of travel in the city. Second, federal policy and the availability of funds guided policies pursued by Phoenix officials to deal with the unintended environmental impacts of growth. For example, federal dollars provided one-third of the funds for the construction of a centralized sewage treatment plant, half the funds to save Camelback Mountain and ninety percent of the construction costs for the West Papago-Inner Loop. Lastly, policy alternatives needed broad and diverse public support, as the public played a critical role, through bond approvals and votes, as well as grassroots campaigning, in integrating environmental values into urban growth policy. Public advocacy campaigns played an important role in setting the policy agenda and framing the policy issues that shaped policy alternatives and the public's receptivity to those choices.

Urban policy decisions are part of a dynamic and ongoing process, where previous decisions result in new challenges that provide an opportunity for debate, and the incorporation of new social values into the decision-making process. While twenty-first century challenges require responses that reflect contemporary macroeconomic factors and social values, the postwar period demonstrates the need for inclusive, collaborative, and anticipatory decision-making.

The overarching purpose of my dissertation is to offer one Pueblo perspective about research and health education to contribute to critical dialogue among Pueblo people so that relevant research and health education approaches grounded in Pueblo thinking can emerge. Research was a pebble in my shoe that caused me great discomfort as I walked within academia during the many years I worked as a health educator at a university, and continues to bother me. The purpose of my journal article is to discuss why much mainstream research is problematic from a Pueblo Indian standpoint and to explore considerations for research with Pueblo people. The purpose of my book chapter is to reflect on my experiences as a Pueblo Indian health educator to add to the discussion about the importance of grounding Pueblo health education in local Pueblo knowledge systems and to discuss the limitations of delivering health education primarily grounded in a western biomedical disease model. Finally, my policy brief is an urgent call to action for tribal leaders regarding a recent change to the New Mexico Department of Health's race and ethnicity presentation in health data standard. This change resulted in 39,636 American Indians and Alaska Natives in New Mexico being reclassified as Hispanic. It is my intention to connect my ideas about research and health education with the work of other Pueblo scholars to add to the growing body of Pueblo informed writing to contribute to current and future scholarship that will ultimately benefit Pueblo people.

A search for Klong to pi0 nu nubar was performed on the initial Physics data taken by the KOTO collaboration by the 30-GeV proton synchrotron at JPARC, located in Tokai, Japan. The detector used in the experiment is an upgraded version of the E391 detector, KOTO's predecessor experiment performed at KEK. The analysis was performed on 2.49 E+11 ± (0.91%)stat ± (2.50%)syst kaon decays. The analysis uses Klong to 3pi0, Klong to 2pi0, and Klong to 2 gamma; for normalization and Monte Carlo validation. Based on my independent analysis, the single event sensitivity was determined to be 1.31 E-8 ± (1.22%)stat ± (7.12%)syst, comparable with the E391 result. An upper limit of 5.12 E-8 was measured for the Klong to pi0 nu nubar branching ratio at a 90% confidence level.

The focus of this in-depth study is to look at the gestation, performance history, and reception of Giacomo Puccini's evening of three one-act operas called Il Trittico and differentiate the particular components, Il Tabarro, Suor Angelica, and Gianni Schicchi to analyze them for their individual stylistic elements of Italian Opera. These were the styles of verismo, pathos and sentimentality, and opera buffa. As substantiated by written criticism, the audience and the critics did not fully comprehend the hidden meaning behind the individual works of Il Trittico. Puccini, enigmatically, had chosen to present one last glimpse of outmoded Italian operatic traditions. In order to evaluate Il Trittico's importance in the history of Italian opera, this study will first review the musically changing landscape in Italy during the early to mid-nineteenth century, then the second part of the nineteenth and beginning of the twentieth-century when German, French, and eventually Russian music were starting to influence audience taste. Puccini who, over the course of his compositional life, absorbed and incorporated these different styles realized that long held Italian operatic tradition had reached a fork in the road. One path would ensure Italian composers a place in this new order and the other a stagnant dead end.

Even though Puccini's triptych garnered primarily negative reviews, the basis for this negativity was the perception that Il Trittico had broken with the historically traditional Italian musical styles. Though the present study acknowledges that break to a degree, it will also present a historically based rationale for the deviation, one left largely unnoticed by Puccini's critics. In the end, this author plans to realize their symbolic importance as a farewell to three uniquely Italian styles and a departure point for a new operatic tradition. Looking forward to the centenary of the work, this author seeks to illuminate how Puccini reached the pinnacle of firmly rooted genres of Italian opera. Ultimately this might help to unravel the enigma of Il Trittico while it continues to secure its rightful place as one of the masterpieces of the Puccini canon.

The focus of this thesis is to study dissolved organic carbon composition and reactivity along the Colorado and Green Rivers. Dissolved organic carbon (DOC) in large-scale, managed rivers is relatively poorly studied as most literature has focused on pristine unmanaged rivers. The Colorado River System is the 7th largest in the North America; there are seventeen large dams along the Colorado and Green River. DOC in rivers and in the lakes formed by dams (reservoirs) undergo photo-chemical and bio-degradation. DOC concentration and composition in these systems were investigated using bulk concentration, optical properties, and fluorescence spectroscopy. The riverine DOC concentration decreased from upstream to downstream but there was no change in the specific ultraviolet absorbance at 254 nm (SUVA254). Total fluorescence also decreased along the river. In general, the fluorescence index (FI) increased slightly, the humification index (HIX) decreased, and the freshness index (β/α) increased from upstream to downstream. Photo-oxidation and biodegradation experiments were used to determine if the observed changes in DOC composition along the river could be driven by these biogeochemical alteration processes.

In two-week natural sunlight photo-oxidation experiments the DOC concentration did not change, while the SUVA254 and TF decreased. In addition, the FI and ‘freshness’ increased and HIX decreased during photo-oxidation. Photo-oxidation can explain the upstream to downstream trends for TF, FI, HIX, and freshness observed in river water. Serial photo-oxidation and biodegradation experiments were performed on water collected from three sites along the Colorado River. Bulk DOC concentration in all samples decreased during the biodegradation portion of the study, but DOC bioavailability was lower in samples that were photo-oxidized prior to the bioavailability study.

The upstream to downstream trends in DOC concentration and composition along the river can be explained by a combination of photo-chemical and microbial degradation. The bulk DOC concentration change is primarily driven by microbial degradation, while the changes in the composition of the fluorescent DOC are driven by photo-oxidation.

Blind and visually impaired individuals have historically demonstrated a low participation in the fields of science, engineering, mathematics, and technology (STEM). This low participation is reflected in both their education and career choices. Despite the establishment of the Americans with Disabilities Act (ADA) and the Individuals with Disabilities Education Act (IDEA), blind and visually impaired (BVI) students continue to academically fall below the level of their sighted peers in the areas of science and math. Although this deficit is created by many factors, this study focuses on the lack of adequate accessible image based materials. Traditional methods for creating accessible image materials for the vision impaired have included detailed verbal descriptions accompanying an image or conversion into a simplified tactile graphic. It is very common that no substitute materials will be provided to students within STEM courses because they are image rich disciplines and often include a large number images, diagrams and charts. Additionally, images that are translated into text or simplified into basic line drawings are frequently inadequate because they rely on the interpretations of resource personnel who do not have expertise in STEM. Within this study, a method to create a new type of tactile 3D image was developed using High Density Polyethylene (HDPE) and Computer Numeric Control (CNC) milling. These tactile image boards preserve high levels of detail when compared to the original print image. To determine the discernibility and effectiveness of tactile images, these customizable boards were tested in various

university classrooms as well as in participation studies which included BVI and sighted students. Results from these studies indicate that tactile images are discernable and were found to improve performance in lab exercises as much as 60% for those with visual impairment. Incorporating tactile HDPE 3D images into a classroom setting was shown to increase the interest, participation and performance of BVI students suggesting that this type of 3D tactile image should be incorporated into STEM classes to increase the participation of these students and improve the level of training they receive in science and math.