ASU Electronic Theses and Dissertations
This collection includes most of the ASU Theses and Dissertations from 2011 to present. ASU Theses and Dissertations are available in downloadable PDF format; however, a small percentage of items are under embargo. Information about the dissertations/theses includes degree information, committee members, an abstract, supporting data or media.
In addition to the electronic theses found in the ASU Digital Repository, ASU Theses and Dissertations can be found in the ASU Library Catalog.
Dissertations and Theses granted by Arizona State University are archived and made available through a joint effort of the ASU Graduate College and the ASU Libraries. For more information or questions about this collection contact or visit the Digital Repository ETD Library Guide or contact the ASU Graduate College at gradformat@asu.edu.
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- Creators: Chassin, Laurie
Description
Pediatric chronic pain is pervasive and associated with myriad adverse consequences, yet due consideration has not been given to the mental health disturbances that often present alongside chronic pain and the etiological mechanisms that potentially underlie both. The current study examined the etiology underlying chronic pain and internalizing symptomology in middle childhood, considering both independent and co-occurring symptom presentations. Phenotypic parent-offspring associations across chronic pain and internalizing symptomology were also examined. Lastly, nuclear twin family models were tested to determine the extent to which genetic and environmental factors underlie parent-offspring transmission. The sample comprised 795 children (399 families; Mage= 9.7 years; SD = 0.92) and their parents drawn from the Arizona Twin Project. Results indicated that chronic pain was highly heritable (78%), whereas internalizing symptomology was modestly heritable (32%) and further subject to moderate shared environmental influence (50%). Moreover, 9% of the variance in chronic pain was explained by additive genetic factors shared with internalizing symptomology. Maternal chronic pain and internalizing symptomology were positively associated with both child chronic pain and internalizing symptomology. The association between maternal chronic pain and child chronic pain was more pronounced for girls than boys, whereas the association between maternal internalizing symptomology and child internalizing symptomology was more pronounced for boys than girls. Paternal chronic pain was not significantly associated with child chronic pain but was unexpectedly associated with lower child internalizing symptomology. The negative association between paternal chronic pain and child internalizing symptomology was more pronounced for boys than girls. Paternal internalizing symptomology was not significantly associated with child chronic pain but was positively associated with child internalizing symptomology. Lastly, the best fitting reduced nuclear twin family models for both chronic pain and internalizing symptomology retained additive genetic, sibling-specific shared environmental, and nonshared environmental parameters, where parent-offspring transmission was solely explained by shared genetics and sibling-specific shared environmental factors further accounted for co-twin resemblance. Results provide novel insight into common liabilities underlying chronic pain and internalizing symptomology in middle childhood, parent-offspring associations across chronic pain and internalizing symptomology, and the etiological mechanisms that explain symptom aggregation across generations.
ContributorsOro, Veronica (Author) / Lemery-Chalfant, Kathryn (Thesis advisor) / Chassin, Laurie (Committee member) / Davis, Mary (Committee member) / Su, Jinni (Committee member) / Arizona State University (Publisher)
Created2021
Description
With the growing popularity of medical cannabis, and high rates of cannabis use disorder (CUD) among medical cannabis users, it is more important than ever to accurately identify the proximal antecedents and subjective effects of medical cannabis use. Subjective antecedents and effects have been proposed as key mechanisms underlying the transition from cannabis use to CUD, but little research has examined medical cannabis users’ experiences in real-time, real-world settings. The current study of 86 young-adult medical cannabis users ages 18-30 (32.6% female) used ecological momentary assessment (EMA) to characterize the antecedents and effects of medical cannabis use, and to examine whether these antecedents and effects vary as a function of CUD severity. Higher craving, pain, and withdrawal symptoms predicted greater odds of cannabis use at the next report, and lower subjective ‘high’ predicted greater odds of cannabis use at the next report. Use of medical cannabis was associated with increases in positive affect, stimulation, relaxation, and subjective ‘high’, decreases in negative affect, withdrawal symptoms, craving, and pain, and increases in cognitive problems, psychotic-like experiences, and adverse bodily effects. Further, following cannabis use, medical users with more CUD symptoms reported greater relief from craving, attenuated increases in stimulation and relaxation, and enhanced increases in sluggishness, cognitive problems, psychotic-like symptoms, and bodily symptoms. Results suggest that medical cannabis use, like recreational use, is associated with a wide range of subjective antecedents and effects, and that relief from cannabis craving may play an important role in the maintenance of CUD among medical users.
ContributorsJones, Connor (Author) / Meier, Madeline H (Thesis advisor) / Chassin, Laurie (Committee member) / Grimm, Kevin J (Committee member) / Corbin, William (Committee member) / Arizona State University (Publisher)
Created2022
Description
Alcohol use remains a major public health concern and economic burden. Extant literature suggests that young adulthood is a particularly high-risk developmental period for heavy drinking. Given this, it is imperative to understand possible risk and protective factors for heavy drinking and related consequences during this risky developmental period. Prior research has shown that both drinking history and alcohol response (AR) are consistent predictors of future drinking outcomes. However, it is unclear how they may work together to confer this risk. The current study aimed to fill this gap in the literature by examining how alcohol use trajectories across adolescence and early adulthood impacted relations between AR after an alcohol challenge and drinking outcomes over a 2-year period in a sample of young adult moderate to heavy drinkers. Results showed that both drinking history and AR were independently predictive of alcohol outcomes at the 6-month follow-up such that a more extensive drinking history, greater high arousal positive effects, and lesser low arousal negative effects predicted greater drinking and alcohol-related problems 6-months later. However, drinking history and AR were largely not predictive of change in drinking outcomes over time. Finally, AR did not mediate the relationship between drinking history and later alcohol-related outcomes. This is the first study to address relations among drinking history, AR, and later drinking outcomes using a longitudinal alcohol challenge design with a full account of early drinking history. Future research would benefit from inclusion of a broad range of drinkers and longer follow-up assessments to better understand the complex pathways of risk from early drinking history and AR to future drinking outcomes. Such efforts may increase the understanding of who is at greatest risk and/or would benefit most from specific intervention programs.
ContributorsHartman, Jessica (Author) / Corbin, William R (Thesis advisor) / Chassin, Laurie (Committee member) / Doane, Leah D (Committee member) / Grimm, Kevin J (Committee member) / Arizona State University (Publisher)
Created2021
Description
The current dissertation combines the results of three recently published papers focused on impulsive personality traits, alcohol and cannabis co-use, and alcohol misuse. The first study used alcohol administration to test whether different impulsivity facets conferred risk for heightened alcohol craving through subjective alcohol response patterns. The second study built on this study by incorporating alcohol and cannabis co-use into the acquired preparedness model, using longitudinal data. This study tested whether generalized impulsivity and sensation seeking during late adolescence predisposed individuals to co-use alcohol and cannabis, and whether co-use was indirectly associated with alcohol problems ten years later through positive expectancies and heavy drinking. The third study tested whether impulsive traits moderated the day-level effect of alcohol and cannabis co-use (vs. alcohol-only) on within-person deviations in drinking quantity on drinking days. Through the combination of these three studies, this dissertation seeks to further advance the literature on multiplicative ways in which personality enacts risk for heavy drinking, alcohol and cannabis co-use, and alcohol problems.
ContributorsWaddell, Jack T. (Author) / Corbin, William R. (Thesis advisor) / Chassin, Laurie (Committee member) / Grimm, Kevin J. (Committee member) / Meier, Madeline H. (Committee member) / Arizona State University (Publisher)
Created2024
Description
Both subjective response to alcohol and acute tolerance possess unique biphasic relations with the blood alcohol concentration curve. However, prior work has generally failed to examine shared relations between the two constructs and has yet to consider the full valence by arousal affective space of subjective response, nor individual differences in metabolism or peak levels of subjective intoxication. As such, the present study sought to characterize acute tolerance to subjective response in addition to examining relations between acute tolerance, subjective response, and related outcomes. Participants (N=258) were randomly assigned to receive alcohol (target blood alcohol concentration = .08 g%) as part of a large placebo-controlled alcohol administration study. Participant family history of alcohol use problems and personal history of alcohol use were collected at baseline. Subjective response to alcohol was assessed across the full valence by arousal affective space at equivalent points on the ascending and descending limbs of the blood alcohol concentration curve. Latent change scores were calculated to characterize the development of acute tolerance, and path analyses tested relations between acute tolerance to subjective response, concurrent patterns of alcohol use, and negative alcohol-related consequences. Age, sex, race/ethnicity, and drinking context were included as covariates. Acute tolerance to low arousal positive (i.e., relaxed, mellow) effects were found to be inversely related to negative consequences such that a maintenance of low arousal positive effects was associated with more negative consequences. The amount of time elapsed between measurements was found to be significantly related to the development of acute tolerance to high arousal positive (i.e., talkative, stimulated) effects, such that more time between measurements was related to a greater decrease in high arousal positive effects. Peak high arousal positive effects were found to be related to increased drinking and indirectly related to more negative consequences via drinking, whereas high arousal negative was protective against increased drinking and negative consequences. Results suggest that a maintenance of negatively reinforcing effects across the blood alcohol concentration curve may confer risk for negative consequences. Results also suggest that considering individual differences in alcohol metabolism may be useful in understanding alcohol’s rewarding, stimulating effects.
ContributorsKing, Scott Edward (Author) / Corbin, William R. (Thesis advisor) / Chassin, Laurie (Committee member) / Grimm, Kevin (Committee member) / Arizona State University (Publisher)
Created2022
Description
Attention-Deficit/Hyperactivity Disorder (ADHD) impacts 7% of children and is associated with serious impairment throughout the lifespan. Though considered a chronic, stable condition, symptoms fluctuate substantially during adolescence, and symptom trajectory is linked to adult outcomes. A small number of studies have examined symptom trajectory during adolescence, but these have predominately examined demographic predictors. As a neurodevelopmental disorder, ADHD is theorized to arise from deficits in executive functions (EFs). Extant literature identifies three major components of EF- working memory, behavioral inhibition, and set shifting- as interrelated constructs underlying ADHD symptom expression. This study aimed to 1.) identify trajectories of ADHD symptoms, 2.) examine demographic predictors of trajectories, and 3.) examine whether EF predicts symptom trajectory using five timepoints from the Adolescent Brain Cognitive Development study, a large-scale, representative, population-based sample from the United States. 1,605 participants meeting criteria for ADHD included in analyses. ADHD symptoms were measured by parent report on the widely used Achenbach Child Behavior Checklist. Growth Mixture Modeling was used to model trajectories of ADHD symptoms. However, poor entropy indicated trajectories were not clearly differentiated and predictors could not be examined. Therefore, exploratory regression was conducted to examine predictors of ADHD symptom change from baseline to 3-year follow-up. Male sex, medication use, greater than high school parental education, and better EF all predicted increasing ADHD symptoms. Findings must be interpreted with caution due to their exploratory nature and poor validity of the measure used for ADHD symptoms, which was found to have sensitivity of only 22.58%. Given the strong theoretical and empirical link between ADHD symptoms and EF, additional research on the connection between EF and disorder trajectory with more robust measures of EF is warranted.
ContributorsChromik, Lindsay C (Author) / Friedman, Lauren (Thesis advisor) / McNeish, Daniel (Committee member) / Chassin, Laurie (Committee member) / Arizona State University (Publisher)
Created2024
Description
The present study tested the respective mediating effects of sensation seeking and initial level of response (LR) to negative, sedative alcohol effects on the relation between the density of familial history of alcoholism and adolescent alcohol use. Additionally, the present study tested the direct effect of LR to negative, sedative alcohol effects on adolescent drinking over and above the effects of sensation seeking; and also tested the moderating effect of sensation seeking on the relation between level of response negative, sedative alcohol effects and adolescent drinking. Specifically, OLS regression models first estimated the effects of sensation seeking, LR to negative, sedative alcohol effects, and their interaction on alcohol outcomes, over and above the influence of covariates. Indirect effects were then tested using the PRODCLIN method through RMediation. Analyses failed to support sensation seeking as a mediator in the relation between familial history of alcoholism and adolescent drinking, and as a moderator of the relation between LR and adolescent drinking. However, analyses did support a robust direct effect of LR to negative, sedative alcohol effects on adolescent alcohol involvement. A significant mediating effect of initial LR to negative, sedative alcohol effects on the relation between familial alcoholism and adolescent drinking was found, however failed to maintain significance in post-hoc analyses attenuating the downward bias of the measure of initial LR. Initial LR to negative, sedative alcohol effects continued to predict adolescent drinking after attenuating measure bias. These findings strengthen research on initial LR to negative, sedative alcohol effects as a risk for greater alcohol involvement in adolescence, and underscore the complexity of studying the familial transmission of alcoholism in adolescent populations
ContributorsPandika, Danielle (Author) / Chassin, Laurie (Thesis advisor) / Corbin, William (Committee member) / Aiken, Leona (Committee member) / Arizona State University (Publisher)
Created2015
Description
Family disruption, or the separation of children from caregivers, has been well-established in prior literature as a risk factor for child maladjustment; however, little is known about how family disruption impacts youth into adulthood, particularly how it influences children’s later parenting of their own offspring. The present study examined whether cumulative family disruption (i.e., parental hospitalization, death, incarceration, divorce) in childhood exerts effects on children’s parenting of their own offspring in adulthood, beyond other demographic characteristics and risk factors. Further, several potential mechanisms were hypothesized to underlie the association between family disruption in the first and second generation (G1-G2) family and later parenting provided from second-generation (G2) adults to third-generation (G3) children. Mediators included conflict and disorganization in the G1-G2 family and dysregulation in the G2 child.
Participants (N = 236 in models that included multiple G2 siblings; N = 110 in models without siblings) were drawn from a larger sample of at-risk (i.e., alcoholic) and comparison families followed longitudinally for over 30 years and across three generations. Four mediation models were estimated to examine effects of two separate G1-G2 family disruption components (deviance-related and health-related disruption) on parenting of G3, mediated by family conflict, family disorganization, and G2 dysregulation. Results indicated that health-related disruption impairs consistency of parenting provided to G3 offspring through conflict in the G1-G2 family. A direct effect of health-related disruption was also seen on parental monitoring. There were no direct or mediated effects of deviance-related disruption on parenting. Implications and future directions will be discussed.
Participants (N = 236 in models that included multiple G2 siblings; N = 110 in models without siblings) were drawn from a larger sample of at-risk (i.e., alcoholic) and comparison families followed longitudinally for over 30 years and across three generations. Four mediation models were estimated to examine effects of two separate G1-G2 family disruption components (deviance-related and health-related disruption) on parenting of G3, mediated by family conflict, family disorganization, and G2 dysregulation. Results indicated that health-related disruption impairs consistency of parenting provided to G3 offspring through conflict in the G1-G2 family. A direct effect of health-related disruption was also seen on parental monitoring. There were no direct or mediated effects of deviance-related disruption on parenting. Implications and future directions will be discussed.
ContributorsBlake, Austin Joy (Author) / Chassin, Laurie (Thesis advisor) / Meier, Madeline (Committee member) / Wolchik, Sharlene (Committee member) / McNeish, Daniel (Committee member) / Arizona State University (Publisher)
Created2019
Description
Past research suggests that both Alcohol Expectancies and Subjective Response are strong predictors of drinking. However, most studies do not account for the shared variance or relations between the two. Social cognitive and expectancy theories suggest that cognitions may distort reality, creating a discrepancy between expected and subjective effects. Only one study has tested the effects of such discrepancies (Morean et al., 2015), but that study was cross-sectional, making it impossible to determine the direction of effects. As such, the present study sought to test prospective associations between expectancy-subjective response interactions and future drinking behavior. Participants (N=448) were randomly assigned to receive alcohol (target blood alcohol alcohol =.08 g%) or placebo, with 270 in the alcohol condition. Alcohol expectancies and subjective response were assessed across the full range of affective space of valence by arousal. Hierarchical regression tested whether expectancies, subjective response, and their interaction predicted follow-up drinking in 258 participants who reached a blood alcohol curve of >.06 (to differentiate blood alcohol curve limbs). Covariates included gender, age, drinking context, and baseline drinking. High arousal subjective response was tested on the ascending limb and low arousal subjective response on the descending limb. High arousal positive expectancies and subjective response interacted to predict future drinking, such that mean and low levels of high arousal positive subjective response were associated with more drinking when expectancies were higher. High arousal negative expectancies and subjective response also interacted to predict future drinking, such that high levels of high arousal negative subjective response marginally predicted more drinking when expectancies were lower. There were no interactions between low arousal positive or low arousal negative expectancies and subjective response. Results suggest that those who expected high arousal positive subjective response but did not receive many of these effects drank more, and those who did not expect to feel high arousal negative subjective response but did in fact feel these effects also drank more. The results suggest that challenging inaccurate positive expectancies and increasing awareness of true negative subjective response may be efficacious ways to reduce drinking.
ContributorsWaddell, Jack Thomas (Author) / Corbin, William R. (Thesis advisor) / Chassin, Laurie (Thesis advisor) / Anderson, Samantha F. (Committee member) / Arizona State University (Publisher)
Created2020
Description
Alcohol use disorder (AUD) causes immense global burden and has a significant impact on economic and societal functioning. Efficacious treatments for AUDs have been well-established within the literature, however the most commonly accessed treatments for AUD are alcohol-related services, such as self-help groups, outpatient clinics, and detoxification centers. Though studies suggest these services are effective at treating AUDs, there are numerous differences between individuals who receive alcohol-related services and individuals who do not, causing selection bias. Furthermore, current studies of alcohol-related services frequently define recovery outcomes as abstinence, which reduces variability in viable recovery outcomes, such as reduction of drinking behaviors. In addition, reduction in drinking and alcohol-related problems should theoretically have an impact on broader aspects of functioning, such as familial functioning. Improved familial context may reduce risk to family members, who are otherwise at heightened risk for emotional and behavioral problems when living with a family member with AUD. The current study investigated the effect of alcohol-related services on binary and continuous drinking outcomes after eliminating selection bias using multiple propensity score approaches, to identify the best methodology for a high-risk community sample of individuals with AUD. Propensity scores were created using logistic regression approaches and boosted regression trees. Matching, weighting, and subclassification were used, and matching was performed both using greedy and global approaches. Results suggested subclassification was the most successful method for real world alcohol-related services samples with moderate sample size. Moreover, findings demonstrated that boosted regression approaches were less successful than logistic regression approaches at minimizing the effects of selection bias on known confounding variables that are highly related to group selection. In addition, after removing the effects of selection bias, there were no significant difference between participants who received alcohol-related services and the comparison control group on drinking or family functioning, though both groups reduced drinking from pre- to post-alcohol-related services receipt. Findings suggest careful selection of quasi-experimental methods is warranted in real-world samples, to ensure optimal removal of selection bias. Moreover, future studies should continue to clarify the profile of individual that benefits from alcohol-related services to inform intervention efforts.
ContributorsSternberg, Ariel (Author) / Chassin, Laurie (Thesis advisor) / Corbin, William (Committee member) / Meier, Madeline (Committee member) / Grimm, Kevin (Committee member) / Arizona State University (Publisher)
Created2021