ASU Electronic Theses and Dissertations
This collection includes most of the ASU Theses and Dissertations from 2011 to present. ASU Theses and Dissertations are available in downloadable PDF format; however, a small percentage of items are under embargo. Information about the dissertations/theses includes degree information, committee members, an abstract, supporting data or media.
In addition to the electronic theses found in the ASU Digital Repository, ASU Theses and Dissertations can be found in the ASU Library Catalog.
Dissertations and Theses granted by Arizona State University are archived and made available through a joint effort of the ASU Graduate College and the ASU Libraries. For more information or questions about this collection contact or visit the Digital Repository ETD Library Guide or contact the ASU Graduate College at gradformat@asu.edu.
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- Creators: Iasemidis, Leonidas
- Creators: Manne, Sai Sravan
Description
Interictal spikes, together with seizures, have been recognized as the two hallmarks of epilepsy, a brain disorder that 1% of the world's population suffers from. Even though the presence of spikes in brain's electromagnetic activity has diagnostic value, their dynamics are still elusive. It was an objective of this dissertation to formulate a mathematical framework within which the dynamics of interictal spikes could be thoroughly investigated. A new epileptic spike detection algorithm was developed by employing data adaptive morphological filters. The performance of the spike detection algorithm was favorably compared with others in the literature. A novel spike spatial synchronization measure was developed and tested on coupled spiking neuron models. Application of this measure to individual epileptic spikes in EEG from patients with temporal lobe epilepsy revealed long-term trends of increase in synchronization between pairs of brain sites before seizures and desynchronization after seizures, in the same patient as well as across patients, thus supporting the hypothesis that seizures may occur to break (reset) the abnormal spike synchronization in the brain network. Furthermore, based on these results, a separate spatial analysis of spike rates was conducted that shed light onto conflicting results in the literature about variability of spike rate before and after seizure. The ability to automatically classify seizures into clinical and subclinical was a result of the above findings. A novel method for epileptogenic focus localization from interictal periods based on spike occurrences was also devised, combining concepts from graph theory, like eigenvector centrality, and the developed spike synchronization measure, and tested very favorably against the utilized gold rule in clinical practice for focus localization from seizures onset. Finally, in another application of resetting of brain dynamics at seizures, it was shown that it is possible to differentiate with a high accuracy between patients with epileptic seizures (ES) and patients with psychogenic nonepileptic seizures (PNES). The above studies of spike dynamics have elucidated many unknown aspects of ictogenesis and it is expected to significantly contribute to further understanding of the basic mechanisms that lead to seizures, the diagnosis and treatment of epilepsy.
ContributorsKrishnan, Balu (Author) / Iasemidis, Leonidas (Thesis advisor) / Tsakalis, Kostantinos (Committee member) / Spanias, Andreas (Committee member) / Si, Jennie (Committee member) / Arizona State University (Publisher)
Created2012
Description
Over the past few decades, there is an increase in demand for various ground robot applications such as warehouse management, surveillance, mapping, infrastructure inspection, etc. This steady increase in demand has led to a significant rise in the nonholonomic differential drive vehicles (DDV) research. Albeit extensive work has been done in developing various control laws for trajectory tracking, point stabilization, formation control, etc., there are still problems and critical questions in regards to design, modeling, and control of DDV’s - that need to be adequately addressed. In this thesis, three different dynamical models are considered that are formed by varying the input/output parameters of the DDV model. These models are analyzed to understand their stability, bandwidth, input-output coupling, and control design properties. Furthermore, a systematic approach has been presented to show the impact of design parameters such as mass, inertia, radius of the wheels, and center of gravity location on the dynamic and inner-loop (speed) control design properties. Subsequently, extensive simulation and hardware trade studies have been conductedto quantify the impact of design parameters and modeling variations on the performance of outer-loop cruise and position control (along a curve). In addition to this, detailed guidelines are provided for when a multi-input multi-output (MIMO) control strategy is advisable over a single-input single-output (SISO) control strategy; when a less stable plant is preferable over a more stable one in order to accommodate performance specifications. Additionally, a multi-robot trajectory tracking implementation based on receding horizon optimization approach is also presented. In most of the optimization-based trajectory tracking approaches found in the literature, only the constraints imposed by the kinematic model are incorporated into the problem. This thesis elaborates the fundamental problem associated with these methods and presents a systematic approach to understand and quantify when kinematic model based constraints are sufficient and when dynamic model-based constraints are necessary to obtain good tracking properties. Detailed instructions are given for designing and building the DDV based on performance specifications, and also, an open-source platform capable of handling high-speed multi-robot research is developed in C++.
ContributorsManne, Sai Sravan (Author) / Rodriguez, Armando A (Thesis advisor) / Si, Jennie (Committee member) / Berman, Spring (Committee member) / Arizona State University (Publisher)
Created2021