ASU Electronic Theses and Dissertations
This collection includes most of the ASU Theses and Dissertations from 2011 to present. ASU Theses and Dissertations are available in downloadable PDF format; however, a small percentage of items are under embargo. Information about the dissertations/theses includes degree information, committee members, an abstract, supporting data or media.
In addition to the electronic theses found in the ASU Digital Repository, ASU Theses and Dissertations can be found in the ASU Library Catalog.
Dissertations and Theses granted by Arizona State University are archived and made available through a joint effort of the ASU Graduate College and the ASU Libraries. For more information or questions about this collection contact or visit the Digital Repository ETD Library Guide or contact the ASU Graduate College at gradformat@asu.edu.
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- Creators: Grys, Thomas
are becoming resistant to multiple antibiotics, many common antibiotics will soon
become ineective. The ineciency of current methods for diagnostics is an important
cause of antibiotic resistance, since due to their relative slowness, treatment plans
are often based on physician's experience rather than on test results, having a high
chance of being inaccurate or not optimal. This leads to a need of faster, pointof-
care (POC) methods, which can provide results in a few hours. Motivated by
recent advances on computer vision methods, three projects have been developed
for bacteria identication and antibiotic susceptibility tests (AST), with the goal of
speeding up the diagnostics process. The rst two projects focus on obtaining features
from optical microscopy such as bacteria shape and motion patterns to distinguish
active and inactive cells. The results show their potential as novel methods for AST,
being able to obtain results within a window of 30 min to 3 hours, a much faster
time frame than the gold standard approach based on cell culture, which takes at
least half a day to be completed. The last project focus on the identication task,
combining large volume light scattering microscopy (LVM) and deep learning to
distinguish bacteria from urine particles. The developed setup is suitable for pointof-
care applications, as a large volume can be viewed at a time, avoiding the need
for cell culturing or enrichment. This is a signicant gain compared to cell culturing
methods. The accuracy performance of the deep learning system is higher than chance
and outperforms a traditional machine learning system by up to 20%.