ASU Electronic Theses and Dissertations
This collection includes most of the ASU Theses and Dissertations from 2011 to present. ASU Theses and Dissertations are available in downloadable PDF format; however, a small percentage of items are under embargo. Information about the dissertations/theses includes degree information, committee members, an abstract, supporting data or media.
In addition to the electronic theses found in the ASU Digital Repository, ASU Theses and Dissertations can be found in the ASU Library Catalog.
Dissertations and Theses granted by Arizona State University are archived and made available through a joint effort of the ASU Graduate College and the ASU Libraries. For more information or questions about this collection contact or visit the Digital Repository ETD Library Guide or contact the ASU Graduate College at gradformat@asu.edu.
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- All Subjects: Optimization
- Creators: Davulcu, Hasan
- Creators: Wu, Teresa
Description
Surgery is one of the most important functions in a hospital with respect to operational cost, patient flow, and resource utilization. Planning and scheduling the Operating Room (OR) is important for hospitals to improve efficiency and achieve high quality of service. At the same time, it is a complex task due to the conflicting objectives and the uncertain nature of surgeries. In this dissertation, three different methodologies are developed to address OR planning and scheduling problem. First, a simulation-based framework is constructed to analyze the factors that affect the utilization of a catheterization lab and provide decision support for improving the efficiency of operations in a hospital with different priorities of patients. Both operational costs and patient satisfaction metrics are considered. Detailed parametric analysis is performed to provide generic recommendations. Overall it is found the 75th percentile of process duration is always on the efficient frontier and is a good compromise of both objectives. Next, the general OR planning and scheduling problem is formulated with a mixed integer program. The objectives include reducing staff overtime, OR idle time and patient waiting time, as well as satisfying surgeon preferences and regulating patient flow from OR to the Post Anesthesia Care Unit (PACU). Exact solutions are obtained using real data. Heuristics and a random keys genetic algorithm (RKGA) are used in the scheduling phase and compared with the optimal solutions. Interacting effects between planning and scheduling are also investigated. Lastly, a multi-objective simulation optimization approach is developed, which relaxes the deterministic assumption in the second study by integrating an optimization module of a RKGA implementation of the Non-dominated Sorting Genetic Algorithm II (NSGA-II) to search for Pareto optimal solutions, and a simulation module to evaluate the performance of a given schedule. It is experimentally shown to be an effective technique for finding Pareto optimal solutions.
ContributorsLi, Qing (Author) / Fowler, John W (Thesis advisor) / Mohan, Srimathy (Thesis advisor) / Gopalakrishnan, Mohan (Committee member) / Askin, Ronald G. (Committee member) / Wu, Teresa (Committee member) / Arizona State University (Publisher)
Created2010
Description
Optimization of surgical operations is a challenging managerial problem for surgical suite directors. This dissertation presents modeling and solution techniques for operating room (OR) planning and scheduling problems. First, several sequencing and patient appointment time setting heuristics are proposed for scheduling an Outpatient Procedure Center. A discrete event simulation model is used to evaluate how scheduling heuristics perform with respect to the competing criteria of expected patient waiting time and expected surgical suite overtime for a single day compared to current practice. Next, a bi-criteria Genetic Algorithm is used to determine if better solutions can be obtained for this single day scheduling problem. The efficacy of the bi-criteria Genetic Algorithm, when surgeries are allowed to be moved to other days, is investigated. Numerical experiments based on real data from a large health care provider are presented. The analysis provides insight into the best scheduling heuristics, and the tradeoff between patient and health care provider based criteria. Second, a multi-stage stochastic mixed integer programming formulation for the allocation of surgeries to ORs over a finite planning horizon is studied. The demand for surgery and surgical duration are random variables. The objective is to minimize two competing criteria: expected surgery cancellations and OR overtime. A decomposition method, Progressive Hedging, is implemented to find near optimal surgery plans. Finally, properties of the model are discussed and methods are proposed to improve the performance of the algorithm based on the special structure of the model. It is found simple rules can improve schedules used in practice. Sequencing surgeries from the longest to shortest mean duration causes high expected overtime, and should be avoided, while sequencing from the shortest to longest mean duration performed quite well in our experiments. Expending greater computational effort with more sophisticated optimization methods does not lead to substantial improvements. However, controlling daily procedure mix may achieve substantial improvements in performance. A novel stochastic programming model for a dynamic surgery planning problem is proposed in the dissertation. The efficacy of the progressive hedging algorithm is investigated. It is found there is a significant correlation between the performance of the algorithm and type and number of scenario bundles in a problem instance. The computational time spent to solve scenario subproblems is among the most significant factors that impact the performance of the algorithm. The quality of the solutions can be improved by detecting and preventing cyclical behaviors.
ContributorsGul, Serhat (Author) / Fowler, John W. (Thesis advisor) / Denton, Brian T. (Thesis advisor) / Wu, Teresa (Committee member) / Zhang, Muhong (Committee member) / Arizona State University (Publisher)
Created2010
Description
Lighting systems and air-conditioning systems are two of the largest energy consuming end-uses in buildings. Lighting control in smart buildings and homes can be automated by having computer controlled lights and window blinds along with illumination sensors that are distributed in the building, while temperature control can be automated by having computer controlled air-conditioning systems. However, programming actuators in a large-scale environment for buildings and homes can be time consuming and expensive. This dissertation presents an approach that algorithmically sets up the control system that can automate any building without requiring custom programming. This is achieved by imbibing the system self calibrating and self learning abilities.
For lighting control, the dissertation describes how the problem is non-deterministic polynomial-time hard(NP-Hard) but can be resolved by heuristics. The resulting system controls blinds to ensure uniform lighting and also adds artificial illumination to ensure light coverage remains adequate at all times of the day, while adjusting for weather and seasons. In the absence of daylight, the system resorts to artificial lighting.
For temperature control, the dissertation describes how the temperature control problem is modeled using convex quadratic programming. The impact of every air conditioner on each sensor at a particular time is learnt using a linear regression model. The resulting system controls air-conditioning equipments to ensure the maintenance of user comfort and low cost of energy consumptions. The system can be deployed in large scale environments. It can accept multiple target setpoints at a time, which improves the flexibility and efficiency of cooling systems requiring temperature control.
The methods proposed work as generic control algorithms and are not preprogrammed for a particular place or building. The feasibility, adaptivity and scalability features of the system have been validated through various actual and simulated experiments.
For lighting control, the dissertation describes how the problem is non-deterministic polynomial-time hard(NP-Hard) but can be resolved by heuristics. The resulting system controls blinds to ensure uniform lighting and also adds artificial illumination to ensure light coverage remains adequate at all times of the day, while adjusting for weather and seasons. In the absence of daylight, the system resorts to artificial lighting.
For temperature control, the dissertation describes how the temperature control problem is modeled using convex quadratic programming. The impact of every air conditioner on each sensor at a particular time is learnt using a linear regression model. The resulting system controls air-conditioning equipments to ensure the maintenance of user comfort and low cost of energy consumptions. The system can be deployed in large scale environments. It can accept multiple target setpoints at a time, which improves the flexibility and efficiency of cooling systems requiring temperature control.
The methods proposed work as generic control algorithms and are not preprogrammed for a particular place or building. The feasibility, adaptivity and scalability features of the system have been validated through various actual and simulated experiments.
ContributorsWang, Yuan (Author) / Dasgupta, Partha (Thesis advisor) / Davulcu, Hasan (Committee member) / Huang, Dijiang (Committee member) / Reddy, T. Agami (Committee member) / Arizona State University (Publisher)
Created2015
Description
Skyline queries are a well-established technique used in multi criteria decision applications. There is a recent interest among the research community to efficiently compute skylines but the problem of presenting the skyline that takes into account the preferences of the user is still open. Each user has varying interests towards each attribute and hence "one size fits all" methodology might not satisfy all the users. True user satisfaction can be obtained only when the skyline is tailored specifically for each user based on his preferences.
This research investigates the problem of preference aware skyline processing which consists of inferring the preferences of users and computing a skyline specific to that user, taking into account his preferences. This research proposes a model that transforms the data from a given space to a user preferential space where each attribute represents the preference of the user. This study proposes two techniques "Preferential Skyline Processing" and "Latent Skyline Processing" to efficiently compute preference aware skylines in the user preferential space. Finally, through extensive experiments and performance analysis the correctness of the recommendations and the algorithm's ability to outperform the naïve ones is confirmed.
This research investigates the problem of preference aware skyline processing which consists of inferring the preferences of users and computing a skyline specific to that user, taking into account his preferences. This research proposes a model that transforms the data from a given space to a user preferential space where each attribute represents the preference of the user. This study proposes two techniques "Preferential Skyline Processing" and "Latent Skyline Processing" to efficiently compute preference aware skylines in the user preferential space. Finally, through extensive experiments and performance analysis the correctness of the recommendations and the algorithm's ability to outperform the naïve ones is confirmed.
ContributorsRathinavelu, Sriram (Author) / Candan, Kasim Selcuk (Thesis advisor) / Davulcu, Hasan (Committee member) / Sarwat, Mohamed (Committee member) / Arizona State University (Publisher)
Created2014
Description
Advances in data collection technologies have made it cost-effective to obtain heterogeneous data from multiple data sources. Very often, the data are of very high dimension and feature selection is preferred in order to reduce noise, save computational cost and learn interpretable models. Due to the multi-modality nature of heterogeneous data, it is interesting to design efficient machine learning models that are capable of performing variable selection and feature group (data source) selection simultaneously (a.k.a bi-level selection). In this thesis, I carry out research along this direction with a particular focus on designing efficient optimization algorithms. I start with a unified bi-level learning model that contains several existing feature selection models as special cases. Then the proposed model is further extended to tackle the block-wise missing data, one of the major challenges in the diagnosis of Alzheimer's Disease (AD). Moreover, I propose a novel interpretable sparse group feature selection model that greatly facilitates the procedure of parameter tuning and model selection. Last but not least, I show that by solving the sparse group hard thresholding problem directly, the sparse group feature selection model can be further improved in terms of both algorithmic complexity and efficiency. Promising results are demonstrated in the extensive evaluation on multiple real-world data sets.
ContributorsXiang, Shuo (Author) / Ye, Jieping (Thesis advisor) / Mittelmann, Hans D (Committee member) / Davulcu, Hasan (Committee member) / He, Jingrui (Committee member) / Arizona State University (Publisher)
Created2014
Description
With the increased demand for genetically modified T-cells in treating hematological malignancies, the need for an optimized measurement policy within the current good manufacturing practices for better quality control has grown greatly. There are several steps involved in manufacturing gene therapy. These steps are for the autologous-type gene therapy, in chronological order, are harvesting T-cells from the patient, activation of the cells (thawing the cryogenically frozen cells after transport to manufacturing center), viral vector transduction, Chimeric Antigen Receptor (CAR) attachment during T-cell expansion, then infusion into patient. The need for improved measurement heuristics within the transduction and expansion portions of the manufacturing process has reached an all-time high because of the costly nature of manufacturing the product, the high cycle time (approximately 14-28 days from activation to infusion), and the risk for external contamination during manufacturing that negatively impacts patients post infusion (such as illness and death).
The main objective of this work is to investigate and improve measurement policies on the basis of quality control in the transduction/expansion bio-manufacturing processes. More specifically, this study addresses the issue of measuring yield within the transduction/expansion phases of gene therapy. To do so, it was decided to model the process as a Markov Decision Process where the decisions being made are optimally chosen to create an overall optimal measurement policy; for a set of predefined parameters.
The main objective of this work is to investigate and improve measurement policies on the basis of quality control in the transduction/expansion bio-manufacturing processes. More specifically, this study addresses the issue of measuring yield within the transduction/expansion phases of gene therapy. To do so, it was decided to model the process as a Markov Decision Process where the decisions being made are optimally chosen to create an overall optimal measurement policy; for a set of predefined parameters.
ContributorsStarkey, Michaela (Author) / Pedrielli, Giulia (Thesis advisor) / Li, Jing (Committee member) / Wu, Teresa (Committee member) / Arizona State University (Publisher)
Created2020