ASU Electronic Theses and Dissertations
This collection includes most of the ASU Theses and Dissertations from 2011 to present. ASU Theses and Dissertations are available in downloadable PDF format; however, a small percentage of items are under embargo. Information about the dissertations/theses includes degree information, committee members, an abstract, supporting data or media.
In addition to the electronic theses found in the ASU Digital Repository, ASU Theses and Dissertations can be found in the ASU Library Catalog.
Dissertations and Theses granted by Arizona State University are archived and made available through a joint effort of the ASU Graduate College and the ASU Libraries. For more information or questions about this collection contact or visit the Digital Repository ETD Library Guide or contact the ASU Graduate College at gradformat@asu.edu.
Displaying 1 - 10 of 186
Filtering by
- All Subjects: Biology
- All Subjects: Educational Psychology
- Genre: Masters Thesis
Description
Coccidioidomycosis, also known as Valley Fever, is a disease caused by the dimorphic soil-dwelling fungus, Coccidioides sp. Coccidioidomycosis is difficult to diagnose because symptoms are similar to community-acquired pneumonia. Current diagnostic tests rely on antibody responses, but immune responses can be delayed and aberrant, resulting in false negative diagnoses. Unlike serology, detection of coccidioidal proteins or other fungal components in blood could distinguish valley fever from other pulmonary infections and provide a definitive diagnosis. Using mass spectrometry (LC-MS/MS) we examined the plasma peptidome from patients with serologically confirmed coccidioidomycosis. Mass spectra were searched using the protein database from the Coccidioides species, generated and annotated by the Broad Institute. 15 of 20 patients with serologically confirmed coccidioidomycosis demonstrated the presence of a peptide in plasma, "PGLDSKSLACTFSQV" (PGLD). The peptide is derived from an open reading frame from a "conserved hypothetical protein" annotated with 2 exons, and to date, found only in the C. posadasii strain Silviera RMSCC 3488 genomic sequence. In this thesis work, cDNA sequence analysis from polyadenylated RNA confirms the peptide sequence and genomic location of the peptide, but does not indicate that the intron in the gene prediction of C. posadasii strain Silviera RMSCC 3488 is present. A monoclonal antibody generated against the peptide bound to a 16kDa protein in T27K coccidioidal lysate. Detecting components of the fungus plasma could be a useful diagnostic tool, especially when serology does not provide a definitive diagnosis.
ContributorsDuffy, Stacy Leigh (Author) / Lake, Douglas (Thesis advisor) / Magee, Dewey Mitch (Committee member) / Antwi, Kwasi (Committee member) / Arizona State University (Publisher)
Created2013
Description
Modified and artificial water sources can be used as a management tool for game and non-game wildlife species. State, federal, and private agencies allocate significant resources to install and maintain artificial water sources (AWS) annually. Capture mark recapture methods were used to sample small mammal communities in the vicinity of five AWS and five paired control sites (treatments) in the surrounding Sonoran desert from October 2011 to May 2012. I measured plant species richness, density, and percent cover in the spring of 2012. A Multi-response Permutation Procedure was used to identify differences in small mammal community abundance, biomass, and species richness by season and treatment. I used Principle Component Analysis to reduce 11 habitat characteristics to five habitat factors. I related rodent occurrence to habitat characteristics using multiple and logistic regression. A total of 370 individual mammals representing three genera and eight species of rodents were captured across 4800 trap nights. Desert pocket mouse (Chaetodipus penicillatus) was the most common species in both seasons and treatments. Whereas rodent community abundance, biomass, and richness were similar between seasons, community variables of AWS were greater than CS. Rodent diversity was similar between treatments. Desert pocket mouse abundance and biomass were twice as high at AWS when compared to controls. Biomass of white-throated woodrat (Neotoma albigula) was five times greater at AWS. Habitat characteristics were similar between treatments. Neither presence of water nor distance to water explained substantial habitat variation. Occurrence of rodent species was associated with habitat characteristics. Desert rodent communities are adapted for arid environments (i.e. Heteromyids) and are not dependent on "free water". Higher abundances of desert pocket mouse at AWS were most likely related to increased disturbance and debris and not the presence of water. The results of this study and previous studies suggest that more investigation is needed and that short term studies may not be able to detect interactions (if any) between AWS and desert small mammal communities.
ContributorsSwitalski, Aaron (Author) / Bateman, Heather L (Thesis advisor) / Miller, William (Committee member) / Alford, Eddie (Committee member) / Arizona State University (Publisher)
Created2013
Description
ABSTRACT 1. Aposematic signals advertise prey distastefulness or metabolic unprofitability to potential predators and have evolved independently in many prey groups over the course of evolutionary history as a means of protection from predation. Most aposematic signals investigated to date exhibit highly chromatic patterning; however, relatives in these toxic groups with patterns of very low chroma have been largely overlooked. 2. We propose that bright displays with low chroma arose in toxic prey species because they were more effective at deterring predation than were their chromatic counterparts, especially when viewed in relatively low light environments such as forest understories. 3. We analyzed the reflectance and radiance of color patches on the wings of 90 tropical butterfly species that belong to groups with documented toxicity that vary in their habitat preferences to test this prediction: Warning signal chroma and perceived chromaticity are expected to be higher and brightness lower in species that fly in open environments when compared to those that fly in forested environments. 4. Analyses of the reflectance and radiance of warning color patches and predator visual modeling support this prediction. Moreover, phylogenetic tests, which correct for statistical non-independence due to phylogenetic relatedness of test species, also support the hypothesis of an evolutionary correlation between perceived chromaticity of aposematic signals and the flight habits of the butterflies that exhibit these signals.
ContributorsDouglas, Jonathan Marion (Author) / Rutowski, Ronald L (Thesis advisor) / Gadau, Juergen (Committee member) / McGraw, Kevin J. (Committee member) / Arizona State University (Publisher)
Created2013
Description
This study looked at ways of understanding how schoolyards might act as meaningful places in children's developing sense of identity and possibility. Photographs and other images such as historical photographs and maps were used to look at how built environments outside of school reflect demographic and social differences within one southwest city. Intersections of children's worlds with various socio-political communities, woven into and through schooling, were examined for evidence of ways that schools act as the embodiment of a community's values: they are the material and observable effects of resource-allocation decisions. And scholarly materials were consulted to examine relationships in the images to existing theories of place, and its effect on children, as well as to consider theories of the hidden curriculum and its relationship to social reproduction, and the nature of visual representation as a form of data rather than strictly in the service of illustrating other forms of data. The focus of the study was on identifying appropriate research methods for investigating ways to understand the importance of the material worlds of school and childhood. Using a combination of visual and narrative approaches to contribute to our understanding of those material worlds, I sought to expose areas of inequity and class differences in ways that children experience schooling, as evidenced by differences in the material environment. Using a mixed-methods approach, created and found images were coded for categories of material culture, such as the existence of fences, trees, views from the playground or walking in the neighborhood at four Tempe schools. Findings were connected to a rich body of knowledge in areas such as theories of space and place, the nature of the hidden curriculum, visual culture, visual research methods including mapping. Familiar aspects of schooling were exposed in different ways, linking past decisions made by adults to their continuing effects on children today. In this way I arrived at an expanded and enriched understanding of the present worlds of children communicated as through the material environment. Visually examining children's worlds, by looking at the material artifacts of everyday worlds that children experience at school and including the child's-eye view in decision processes, has promise in moving decision makers away from strictly analytical and impersonal approaches to decision making about schooling children of the future. I proposed that by weighting of data points, as used in decision-making processes regarding schooling, differently than is currently done, and by paying closer attention to possible longer-term effects of place for all children, not just a few, there is the potential to improve the quality of life for today's children, and tomorrow's adults.
ContributorsWalsum, Joyce Van (Author) / Margolis, Eric M. (Thesis advisor) / Green, Samuel (Thesis advisor) / Collins, Daniel (Committee member) / Arizona State University (Publisher)
Created2013
Description
Dimensionality assessment is an important component of evaluating item response data. Existing approaches to evaluating common assumptions of unidimensionality, such as DIMTEST (Nandakumar & Stout, 1993; Stout, 1987; Stout, Froelich, & Gao, 2001), have been shown to work well under large-scale assessment conditions (e.g., large sample sizes and item pools; see e.g., Froelich & Habing, 2007). It remains to be seen how such procedures perform in the context of small-scale assessments characterized by relatively small sample sizes and/or short tests. The fact that some procedures come with minimum allowable values for characteristics of the data, such as the number of items, may even render them unusable for some small-scale assessments. Other measures designed to assess dimensionality do not come with such limitations and, as such, may perform better under conditions that do not lend themselves to evaluation via statistics that rely on asymptotic theory. The current work aimed to evaluate the performance of one such metric, the standardized generalized dimensionality discrepancy measure (SGDDM; Levy & Svetina, 2011; Levy, Xu, Yel, & Svetina, 2012), under both large- and small-scale testing conditions. A Monte Carlo study was conducted to compare the performance of DIMTEST and the SGDDM statistic in terms of evaluating assumptions of unidimensionality in item response data under a variety of conditions, with an emphasis on the examination of these procedures in small-scale assessments. Similar to previous research, increases in either test length or sample size resulted in increased power. The DIMTEST procedure appeared to be a conservative test of the null hypothesis of unidimensionality. The SGDDM statistic exhibited rejection rates near the nominal rate of .05 under unidimensional conditions, though the reliability of these results may have been less than optimal due to high sampling variability resulting from a relatively limited number of replications. Power values were at or near 1.0 for many of the multidimensional conditions. It was only when the sample size was reduced to N = 100 that the two approaches diverged in performance. Results suggested that both procedures may be appropriate for sample sizes as low as N = 250 and tests as short as J = 12 (SGDDM) or J = 19 (DIMTEST). When used as a diagnostic tool, SGDDM may be appropriate with as few as N = 100 cases combined with J = 12 items. The study was somewhat limited in that it did not include any complex factorial designs, nor were the strength of item discrimination parameters or correlation between factors manipulated. It is recommended that further research be conducted with the inclusion of these factors, as well as an increase in the number of replications when using the SGDDM procedure.
ContributorsReichenberg, Ray E (Author) / Levy, Roy (Thesis advisor) / Thompson, Marilyn S. (Thesis advisor) / Green, Samuel B. (Committee member) / Arizona State University (Publisher)
Created2013
Description
Random peptide microarrays are a powerful tool for both the treatment and diagnostics of infectious diseases. On the treatment side, selected random peptides on the microarray have either binding or lytic potency against certain pathogens cells, thus they can be synthesized into new antimicrobial agents, denoted as synbodies (synthetic antibodies). On the diagnostic side, serum containing specific infection-related antibodies create unique and distinct "pathogen-immunosignatures" on the random peptide microarray distinct from the healthy control serum, and this different mode of binding can be used as a more precise measurement than traditional ELISA tests. My thesis project is separated into these two parts: the first part falls into the treatment side and the second one focuses on the diagnostic side. My first chapter shows that a substitution amino acid peptide library helps to improve the activity of a recently reported synthetic antimicrobial peptide selected by the random peptide microarray. By substituting one or two amino acids of the original lead peptide, the new substitutes show changed hemolytic effects against mouse red blood cells and changed potency against two pathogens: Staphylococcus aureus and Pseudomonas aeruginosa. Two new substitutes are then combined together to form the synbody, which shows a significantly antimicrobial potency against Staphylococcus aureus (<0.5uM). In the second chapter, I explore the possibility of using the 10K Ver.2 random peptide microarray to monitor the humoral immune response of dengue. Over 2.5 billion people (40% of the world's population) live in dengue transmitting areas. However, currently there is no efficient dengue treatment or vaccine. Here, with limited dengue patient serum samples, we show that the immunosignature has the potential to not only distinguish the dengue infection from non-infected people, but also the primary dengue infection from the secondary dengue infections, dengue infection from West Nile Virus (WNV) infection, and even between different dengue serotypes. By further bioinformatic analysis, we demonstrate that the significant peptides selected to distinguish dengue infected and normal samples may indicate the epitopes responsible for the immune response.
ContributorsWang, Xiao (Author) / Johnston, Stephen Albert (Thesis advisor) / Blattman, Joseph (Committee member) / Arntzen, Charles (Committee member) / Arizona State University (Publisher)
Created2013
Description
Biological diversity is threatened by increasing anthropogenic modification of natural environments and increasing demands on natural resources. Sonoran desert tortoises (Gopherus morafkai) currently have Candidate status under the Endangered Species Act (ESA) based on health and habitat threats. To ensure this animal persists in the midst of multiple threats requires an understanding of the life history and ecology of each population. I looked at one physiological and one behavioral aspect of a population of tortoises at the Sugarloaf Mountain (SL) study site in central Arizona, USA. I used 21 years of capture-recapture records to estimate growth parameters of the entire population. I investigated habitat selection of juvenile tortoises by selecting 117 locations of 11 tortoises that had been tracked by radio-telemetry one to three times weekly for two years, selecting locations from both summer active season and during winter hibernation. I compared 22 microhabitat variables of tortoise locations to random SL locations to determine habitat use and availability. Male tortoises at SL reach a greater asymptotic length than females, and males and females appear to grow at the same rate. Juvenile tortoises at the SL site use steep rocky hillsides with high proportions of sand and annual vegetation, few succulents, and enclosed shelters in summer. They use enclosed shelters on steep slopes for winter hibernation. An understanding of these features can allow managers to quantify Sonoran desert tortoise habitat needs and life history characteristics and to understand the impact of land use policies.
ContributorsBridges, Andrew (Author) / Bateman, Heather L (Thesis advisor) / Miller, William (Committee member) / Ulrich, Jon (Committee member) / Arizona State University (Publisher)
Created2012
Description
The Student Performance Accomplishments Questionnaire (SPAQ) was developed and validated in two studies with two normative samples totaling 315 college students, including a subsample of undocumented students. This instrument assesses academic performance accomplishments in the context of students' academic, extracurricular, and advocacy roles. Performance accomplishments are theorized to be one of four sources of efficacy (Bandura, 1977, 1986). Study 2 tested part of the Social Cognitive Career Theory model (Lent et al., 1994) in a sample of 154 student advocates. By conventional standards, the results yielded no support for the SCCT model and suggested the need for an alternative model. Results showed that student performance accomplishments in advocacy are highly related to students' academic outcomes, particularly choice actions. Choice actions were subsequently related to career goals and academic performance. No significant differences were found between documented and undocumented students on any of the variables studied. It was found that student advocates were significantly higher in performance accomplishments in advocacy, academic self-efficacy, choice action, and academic performance in comparison to student non-advocates. Clinical and research implications of these results for the field of counseling psychology were discussed.
ContributorsCadenas, German (Author) / Bernstein, Bianca L. (Thesis advisor) / Kurpius, Sharon E. (Committee member) / Arciniega, Guillermo M. (Committee member) / Arizona State University (Publisher)
Created2013
Description
The development of literacy abilities in young children has been a major concern for authorities and teachers in the USA for the last two decades. Significant effort has been devoted to ensure that preschool settings allow and motivate children to engage in literacy activities before entering kindergarten. Research has found that a rich classroom environment in preschool settings enables teachers to encourage literacy interest in children at a young age. While a large amount of research has concentrated in testing the effect of prescriptive modifications in the classroom environment, few have focused on studying the design process and tools that teachers follow to design their classrooms. Public policy and research studies in the United States, mention the design of the classroom environment among teacher's responsibilities, but they do not include practical or methodological guides for them to use. The purpose of this research was to study the design process and tools that teachers use to design literacy rich classrooms in preschool settings. A case study was conducted at the ASU Mary Lou Fulton Teachers College Preschool at Arizona State University. This setting provides a unique opportunity for an exploratory study of this nature because it is a private child development laboratory with a flexible curriculum. Participant observation sessions and in depth semi-structured interviews were conducted to explore the design process used and experienced by the teachers. Findings revealed an iterative and cyclic design process that is repeated over time adjusting to the influence of numerous factors. Results also suggest that teacher's knowledge and beliefs highly influence the organization of their classrooms. Considering these factors as a standpoint allows for further exploration to determine a design process suitable for teachers when designing their learning environments. The use of a structured yet flexible design process, can be a potential tool for educators to design their classrooms, collaborate, document and transmit their knowledge. Although the findings correspond to a specific site studied, the implications are wide reaching as problems and opportunities expressed by the staff are common to other educational settings with similar characteristics.
ContributorsCortes, Catalina (Author) / Patel, Mookesh (Thesis advisor) / Heywood, William (Committee member) / Christie, James (Committee member) / Arizona State University (Publisher)
Created2013
Description
ABSTRACT Students who drop out of high school experience lower incomes and greater unemployment and are at higher risk of becoming part of the adult corrections system and of needing public assistance. Historically, Latino/a youth, particularly Mexican American youth, have been at particularly high risk for underachievement and dropping out of high school. Because Latino/as are the fastest growing ethnic group in the United States, their struggle in education means a larger, undereducated work force. In spite of demographic factors such as poverty, language barriers, and discrimination that potentially can adversely impact the success of the children of Mexican immigrant parents, some of these parents are taking steps to help their children succeed in high school and to enter college. While parental involvement has been generally linked to improving students' outcomes and attitudes toward school, few studies have focused on minority parents, particularly Latino/as. Even fewer have conducted qualitative studies to develop a deeper understanding of parents' beliefs, values, and actions taken to help their children. Through semi-structured interviews and grounded theory analysis, this qualitative study investigated how and why Mexican immigrant parents help their children succeed in school. Six themes emerged from the data: 1) parents' motivations stem from childhood adversity, the belief that there are opportunities in the U.S. for people who succeed academically, and unrealized dreams to pursue their own education; 2) parents' actions primarily included behaviors at home; 3) the influence of "La Familia" (the protective force of the family); 4) the influence of discipline; 5) the influence of teachers and principals who recognized and supported their children's academic success; and 6) the influence of the children themselves. Despite variations in educational attainment and income levels, the parents' values, beliefs, and actions were similar to each other and reflect their Mexican cultural upbringing. By developing a deeper understanding of the parents' beliefs, values, and actions, more culturally informed and strength-based, parent-involvement approaches can be developed for similar Mexican immigrant parents. Implications, limitations, and suggestions for future research are explored.
ContributorsGoldsmith, Jill S (Author) / Robinson Kurpius, Sharon (Thesis advisor) / Randall, Ashley K. (Committee member) / Arciniega, G. Miguel (Committee member) / Arizona State University (Publisher)
Created2014