ASU Electronic Theses and Dissertations
This collection includes most of the ASU Theses and Dissertations from 2011 to present. ASU Theses and Dissertations are available in downloadable PDF format; however, a small percentage of items are under embargo. Information about the dissertations/theses includes degree information, committee members, an abstract, supporting data or media.
In addition to the electronic theses found in the ASU Digital Repository, ASU Theses and Dissertations can be found in the ASU Library Catalog.
Dissertations and Theses granted by Arizona State University are archived and made available through a joint effort of the ASU Graduate College and the ASU Libraries. For more information or questions about this collection contact or visit the Digital Repository ETD Library Guide or contact the ASU Graduate College at gradformat@asu.edu.
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Description
Growers and the USDA showed increasing favor for agricultural chemicals over cultural and biological forms of pest control through the first half of the twentieth century. With the introduction of DDT and other synthetic chemicals to commercial markets in the post-World War II era, pesticides became entrenched as the primary form of pest control in the industrial agriculture production system. Despite accumulating evidence that some pesticides posed a threat to human and environmental health, growers and government exercised path-dependent behavior in the development and implementation of pest control strategies. As pests developed resistance to regimens of agricultural chemicals, growers applied pesticides with greater toxicity in higher volumes to their fields with little consideration for the unintended consequences of using the economic poisons. Consequently, pressure from non-governmental organizations proved a necessary predicate for pesticide reform. This dissertation uses a series of case studies to examine the role of non-governmental organizations, particularly environmental organizations and farmworker groups, in pesticide reform from 1962 to 2011. For nearly fifty years, these groups served as educators, communicating scientific and experiential information about the adverse effects of pesticides on human health and environment to the public, and built support for the amendment of pesticide policies and the alteration of pesticide use practices. Their efforts led to the passage of more stringent regulations to better protect farmworkers, the public, and the environment. Environmental organizations and farmworker groups also acted as watchdogs, monitoring the activity of regulatory agencies and bringing suit when necessary to ensure that they fulfilled their responsibilities to the public. This dissertation will build on previous scholarly work to show increasing collaboration between farmworker groups and environmental organizations. It argues that the organizations shared a common concern about the effects of pesticides on human health, which enabled bridge-builders within the disparate organizations to foster cooperative relationships. Bridge-building proved a mutually beneficial exercise. Variance in organizational strategies and the timing of different reform efforts limited, but did not eliminate, opportunities for collaboration. Coalitions formed when groups came together temporarily, and then drifted apart when a reform effort reached its terminus, leaving future collaboration still possible.
ContributorsTompkins, Adam (Author) / Hirt, Paul (Thesis advisor) / Rome, Adam (Committee member) / Adamson, Joni (Committee member) / Rosales, F (Committee member) / Arizona State University (Publisher)
Created2011
Description
The elaborate signals of animals are often costly to produce and maintain, thus communicating reliable information about the quality of an individual to potential mates or competitors. The properties of the sensory systems that receive signals can drive the evolution of these signals and shape their form and function. However, relatively little is known about the ecological and physiological constraints that may influence the development and maintenance of sensory systems. In the house finch (Carpodacus mexicanus) and many other bird species, carotenoid pigments are used to create colorful sexually selected displays, and their expression is limited by health and dietary access to carotenoids. Carotenoids also accumulate in the avian retina, protecting it from photodamage and tuning color vision. Analogous to plumage carotenoid accumulation, I hypothesized that avian vision is subject to environmental and physiological constraints imposed by the acquisition and allocation of carotenoids. To test this hypothesis, I carried out a series of field and captive studies of the house finch to assess natural variation in and correlates of retinal carotenoid accumulation and to experimentally investigate the effects of dietary carotenoid availability, immune activation, and light exposure on retinal carotenoid accumulation. Moreover, through dietary manipulations of retinal carotenoid accumulation, I tested the impacts of carotenoid accumulation on visually mediated foraging and mate choice behaviors. My results indicate that avian retinal carotenoid accumulation is variable and significantly influenced by dietary carotenoid availability and immune system activity. Behavioral studies suggest that retinal carotenoid accumulation influences visual foraging performance and mediates a trade-off between color discrimination and photoreceptor sensitivity under dim-light conditions. Retinal accumulation did not influence female choice for male carotenoid-based coloration, indicating that a direct link between retinal accumulation and sexual selection for coloration is unlikely. However, retinal carotenoid accumulation in males was positively correlated with their plumage coloration. Thus, carotenoid-mediated visual health and performance or may be part of the information encoded in sexually selected coloration.
ContributorsToomey, Matthew (Author) / McGraw, Kevin J. (Thesis advisor) / Deviche, Pierre (Committee member) / Smith, Brian (Committee member) / Rutowski, Ronald (Committee member) / Verrelli, Brian (Committee member) / Arizona State University (Publisher)
Created2011
Description
Molecular dynamics (MD) simulations provide a particularly useful approach to understanding conformational change in biomolecular systems. MD simulations provide an atomistic, physics-based description of the motions accessible to biomolecular systems on the pico- to micro-second timescale, yielding important insight into the free energy of the system, the dynamical stability of contacts and the role of correlated motions in directing the motions of the system. In this thesis, I use molecular dynamics simulations to provide molecular mechanisms that rationalize structural, thermodynamic, and mutation data on the interactions between the lac repressor headpiece and its O1 operator DNA as well as the ERK2 protein kinase. I performed molecular dynamics simulations of the lac repressor headpiece - O1 operator complex at the natural angle as well as at under- and overbent angles to assess the factors that determine the natural DNA bending angle. I find both energetic and entropic factors contribute to recognition of the natural angle. At the natural angle the energy of the system is minimized by optimization of protein-DNA contacts and the entropy of the system is maximized by release of water from the protein-DNA interface and decorrelation of protein motions. To identify the mechanism by which mutations lead to auto-activation of ERK2, I performed a series of molecular dynamics simulations of ERK1/2 in various stages of activation as well as the constitutively active Q103A, I84A, L73P and R65S ERK2 mutants. My simulations indicate the importance of domain closure for auto-activation and activity regulation. My results enable me to predict two loss-of-function mutants of ERK2, G83A and Q64C, that have been confirmed in experiments by collaborators. One of the powerful capabilities of MD simulations in biochemistry is the ability to find low free energy pathways that connect and explain disparate structural data on biomolecular systems. An extention of the targeted molecular dynamics technique using constraints on internal coordinates will be presented and evaluated. The method gives good results for the alanine dipeptide, but breaks down when applied to study conformational changes in GroEL and adenylate kinase.
ContributorsBarr, Daniel Alan (Author) / van der Vaart, Arjan (Thesis advisor) / Matyushov, Dmitry (Committee member) / Wolf, George (Committee member) / Shumway, John (Committee member) / Arizona State University (Publisher)
Created2011
Description
Composition historians have increasingly recognized that local histories help test long-held theories about the development of composition in higher education. As Gretchen Flesher Moon argues, local histories complicate our notions of students, teachers, institutions, and influences and add depth and nuance to the dominant narrative of composition history. Following the call for local histories in rhetoric and composition, this study is a local history of composition at Arizona State University (ASU) from 1885-1985. This study focuses on the institutional influences that shaped writing instruction as the school changed from a normal school to teachers` college, state college, and research university during its first century in existence. Building from archival research and oral histories, this dissertation argues that four national movements in higher education--the normal school movement, the standardization and accreditation movement, the "university-status movement," and the research and tenure movement--played a formative role in the development of writing instruction at Arizona State University. This dissertation, therefore, examines the effects of these movements as they filtered into the writing curriculum at ASU. I argue that faculty and administrators` responses to these movements directly influenced the place of writing instruction in the curriculum, which consequently shaped who took writing courses and who taught them, as well as how, what, and when writing was taught. This dissertation further argues that considering ASU`s history in relation to the movements noted above has implications for composition historians attempting to understand broader developments in composition history during the nineteenth and twentieth centuries. Notwithstanding ASU`s unique circumstances, these movements had profound effects at institutions across the country, shaping missions, student populations, and institutional expectations. Although ASU`s local history is filled with idiosyncrasies and peculiarities that highlight the school`s distinctiveness, ASU is representative of hundreds of institutions across the country that were influenced by national education movements which are often invisible in the dominant narrative of composition history. As such, this history upholds the goal of local histories by complicating our notions of students, teachers, institutions, and influences and adding depth and nuance to our understanding of how composition developed in institutions of American higher education.
ContributorsSkinnell, Ryan (Author) / Goggin, Maureen Daly (Thesis advisor) / Roen, Duane (Thesis advisor) / Matsuda, Paul Kei (Committee member) / Rose, Shirley K. (Committee member) / Arizona State University (Publisher)
Created2011
Description
The rights of American Indians occupy a unique position within the legal framework of water allocations in the western United States. However, in the formulation and execution of policies that controlled access to water in the desert Southwest, federal and local governments did not preserve the federal reserved water rights that attached to Indian reservations as part of their creation. Consequentially, Indian communities were unable to access the water supplies necessary to sustain the economic development of their reservations. This dissertation analyzes the legal and historical dimensions of the conflict over rights that occurred between Indian communities and non-Indian water users in Arizona during the second half of the twentieth century. Particular attention is paid to negotiations involving local, state, federal, and tribal parties, which led to the Congressional authorization of water rights settlements for several reservations in central Arizona. The historical, economic, and political forces that shaped the settlement process are analyzed in order to gain a better understanding of how water users managed uncertainty regarding their long-term water supplies. The Indian water rights settlement process was made possible through a reconfiguration of major institutional, legal, and policy arrangements that dictate the allocation of water supplies in Arizona.
ContributorsKilloren, Daniel (Author) / Hoerder, Dirk (Thesis advisor) / Hirt, Paul (Committee member) / Smith, Karen (Committee member) / Arizona State University (Publisher)
Created2011
Description
Historians often characterize first ladies in the Progressive Era as representatives of the last vestiges of Victorian womanhood in an increasingly modern society. This dissertation argues that first ladies negotiated an image of themselves that fulfilled both traditional and modern notions of womanhood. In crafting these images, first ladies constructed images of their celebrity selves that were uniquely modern. Thus, images of first ladies in the Progressive Era show them as modest and feminine but also autonomous, intelligent, and capable. Using the historian Charles Ponce de Leon's research on modern human-interest journalism, I contend that first ladies in the Progressive Era worked with the modern press in a symbiotic relationship. This relationship allowed the press exclusive access to what was, ostensibly, the first lady's private, and therefore authentic, self. By purporting to reveal parts of their private lives in the press, first ladies showed themselves as down-to-earth despite their success and fulfilled by their domestic pursuits despite their compelling public lives. By offering the press exclusive access to their lives, first ladies secured the opportunity to shape specific images of themselves to appeal, as broadly as possible, to their husbands and parties' constituents and the American public. First ladies in the Progressive Era thus acted as political figures by using both public and private, or what historian Catherine Allgor terms, "unofficial spaces" to support and reflect their husbands and parties' political agendas. In examining representations of first ladies in popular magazines and newspapers from 1901 to 1921 in tandem with letters, memoirs, and other personal papers from these women, a clear pattern emerges. Despite personal differences, first ladies in the Progressive Era represented themselves according to a specific formula in the modern press. The images, constructed by first ladies in this time period, reflect shifts in economic, social, and political life in Progressive Era America, which called for women to be independent and intelligent yet still maintain their femininity and domesticity.
ContributorsHorohoe, Jill (Author) / Gullett, Gayle (Thesis advisor) / Longley, Rodney K (Committee member) / Warren-Findley, Jannelle (Committee member) / Arizona State University (Publisher)
Created2011
Description
The Victorian era was the age of museum development in the United States. In the wake of these institutions, another important figure of the nineteenth century emerged--the flâneur. The flâneur represents the city, and provided new mechanisms of seeing to the public. The flâneur taught citizens how to gaze with a panoptic eye. The increasing importance of cultural institutions contributed to a new means of presenting power and interacting with the viewing public. Tony Bennett's exhibitionary complex theory, argues that nineteenth-century museums were institutions of power that educated, civilized, and through surveillance, encourage self-regulation of crowds. The flâneur's presence in the nineteenth century informed the public about modes of seeing and self-regulation--which in turn helped establish Bennett's theory inside the museum. The popular writing and literature of the time provides an opportunity to examine the extent of the exhibitionary complex and the flâneur. One of the most prominent nineteenth-century authors, Henry James, not only utilizes museums in his work, but he often uses them in just the manner Bennett puts forth in his theory. This is significant because the ideas about museums in James's work shaped the minds of an expanding literary public in the United States, and further educated, civilized, and regulated readers. James also represents the flâneur in his writing, which speaks to broader cultural implications of the both exhibitionary complex on the outside world, and the effects of broader cultural influences on the museum. Beyond the impact of James's work, in the late nineteenth century American culture increasingly became centered around the printed word. The central position of books in American culture at the end of the nineteenth century allowed books and libraries to appropriate the exhibitionary complex and become tools of power in their own right. The book and the library relate to the museum as part of a larger cultural environment, which emerged as a result of modernity and a response to the ever-changing nineteenth-century world.
ContributorsHarrison, Leah Gibbons (Author) / Szuter, Christine (Thesis advisor) / Warren-Findley, Jannelle (Committee member) / Toon, Richard (Committee member) / Arizona State University (Publisher)
Created2011
Description
A synbody is a newly developed protein binding peptide which can be rapidly produced by chemical methods. The advantages of the synbody producing process make it a potential human proteome binding reagent. Most of the synbodies are designed to bind to specific proteins. The peptides incorporated in a synbody are discovered with peptide microarray technology. Nevertheless, the targets for unknown synbodies can also be discovered by searching through a protein mixture. The first part of this thesis mainly focuses on the process of target searching, which was performed with immunoprecipitation assays and mass spectrometry analysis. Proteins are pulled down from the cell lysate by certain synbodies, and then these proteins are identified using mass spectrometry. After excluding non-specific bindings, the interaction between a synbody and its real target(s) can be verified with affinity measurements. As a specific example, the binding between 1-4-KCap synbody and actin was discovered. This result proved the feasibility of the mass spectrometry based method and also suggested that a high throughput synbody discovery platform for the human proteome could be developed. Besides the application of synbody development, the peptide microarray technology can also be used for immunosignatures. The composition of all types of antibodies existing in one's blood is related to an individual's health condition. A method, called immunosignaturing, has been developed for early disease diagnosis based on this principle. CIM10K microarray slides work as a platform for blood antibody detection in immunosignaturing. During the analysis of an immunosignature, the data from these slides needs to be validated by using landing light peptides. The second part of this thesis focuses on the validation of the data. A biotinylated peptide was used as a landing light on the new CIM10K slides. The data was collected in several rounds of tests and indicated that the variation among landing lights was significantly reduced by using the newly prepared biotinylated peptide compared with old peptide mixture. Several suggestions for further landing light improvement are proposed based on the results.
ContributorsSun, Minyao (Author) / Johnston, Stephen Albert (Thesis advisor) / Diehnelt, Chris Wayne (Committee member) / Stafford, Phillip (Committee member) / Arizona State University (Publisher)
Created2011
Description
In the 1970s James Watson recognized the inability of conventional DNA replication machinery to replicate the extreme termini of chromosomes known as telomeres. This inability is due to the requirement of a building block primer and was termed the end replication problem. Telomerase is nature's answer to the end replication problem. Telomerase is a ribonucleoprotein which extends telomeres through reverse transcriptase activity by reiteratively copying a short intrinsic RNA sequence to generate 3' telomeric extensions. Telomeres protect chromosomes from erosion of coding genes during replication, as well as differentiate native chromosome ends from double stranded breaks. However, controlled erosion of telomeres functions as a naturally occurring molecular clock limiting the replicative capacity of cells. Telomerase is over activated in many cancers, while inactivation leads to multiple lifespan limiting human diseases. In order to further study the interaction between telomerase RNA (TR) and telomerase reverse transcriptase protein (TERT), vertebrate TERT fragments were screened for solubility and purity following bacterial expression. Soluble fragments of medaka TERT including the RNA binding domain (TRBD) were identified. Recombinant medaka TRBD binds specifically to telomerase RNA CR4/CR5 region. Ribonucleotide and amino acid pairs in close proximity within the medaka telomerase RNA-protein complex were identified using photo-activated cross-linking in conjunction with mass spectrometry. The identified cross-linking amino acids were mapped on known crystal structures of TERTs to reveal the RNA interaction interface of TRBD. The identification of this RNA TERT interaction interface furthers the understanding of the telomerase complex at a molecular level and could be used for the targeted interruption of the telomerase complex as a potential cancer treatment.
ContributorsBley, Christopher James (Author) / Chen, Julian (Thesis advisor) / Allen, James (Committee member) / Ghirlanda, Giovanna (Committee member) / Arizona State University (Publisher)
Created2011
Description
This thesis explores the story behind the long effort to achieve Native American suffrage in Arizona. It focuses on two Arizona Supreme Court cases, in which American Indians attempted, and were denied the right to register to vote. The first trial occurred in 1928, four years after the Indian Citizenship Act granted citizenship to all Native Americans born or naturalized in the United States. The Arizona Supreme Court rejected the Native American plaintiff's appeal to register for the electorate, and subsequently disenfranchised Native Americans residing on reservations for the next twenty years. In 1948, a new generation of Arizona Supreme Court Justices overturned the court's previous ruling and finally awarded voting rights to all qualified Native Americans in the state. However, voting rights during the Civil Rights era did not necessarily mean equal voting rights. Therefore, this thesis also investigates how the Voting Rights Act of 1965 greatly reduced the detrimental effects of voter discrimination. This study examines how national events, like world war and the Great Depression influenced the two trials. In particular, this thesis focuses on the construction of political and social power in Arizona as it related to Native American voting rights. In addition, it discusses the evolution of native citizenship in the United States at large and for the most part within Arizona. The thesis also considers how the goal of native assimilation into American society affected American Indian citizenship, and how a paternalistic and conservative American Indian policy of the 1920s greatly influenced the outcome of the first trial. Another thread of this story is the development of mainstream white views of Native Americans. Lastly, this thesis identifies the major players of this story, especially the American Indian activists and their supporters whose courage and perseverance led to an outcome that positively changed the legal rights of generations of Native Americans in Arizona for years to come.
ContributorsBassett, Jenna (Author) / Fixico, Donald (Thesis advisor) / Osburn, Katherine (Committee member) / Sturgeon, Melanie (Committee member) / Warren-Findley, Jannelle (Committee member) / Arizona State University (Publisher)
Created2011