ASU Electronic Theses and Dissertations
This collection includes most of the ASU Theses and Dissertations from 2011 to present. ASU Theses and Dissertations are available in downloadable PDF format; however, a small percentage of items are under embargo. Information about the dissertations/theses includes degree information, committee members, an abstract, supporting data or media.
In addition to the electronic theses found in the ASU Digital Repository, ASU Theses and Dissertations can be found in the ASU Library Catalog.
Dissertations and Theses granted by Arizona State University are archived and made available through a joint effort of the ASU Graduate College and the ASU Libraries. For more information or questions about this collection contact or visit the Digital Repository ETD Library Guide or contact the ASU Graduate College at gradformat@asu.edu.
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The desire to start a family is something millions of people around the globe strive to achieve. However, many factors such as the societal changes in family planning due to increasing maternal age, use of birth control, and ever-changing lifestyles have increased the number of infertility cases seen in the United States each year. Infertility can manifest as a prolonged inability to conceive, or inability to carry a pregnancy full-term. Modern advancements in the field of reproductive medicine have begun to promote the use of Assisted Reproductive Technologies (ART) to circumvent reduced fertility in both men and women. Implementation of techniques such as In Vitro Fertilization, Intracytoplasmic Sperm Injection, and Pre-Implantation Genetic Testing have allowed many couples to conceive. There is continual effort being made towards developing more effective and personalized fertility treatments. This often begins in the form of animal research—a fundamental step in biomedical research. This dissertation examines infertility as a medical condition through the characterization of normal reproductive anatomy and physiology in the introductory overview of reproduction. Specific pathologies of male and female-factor infertility are described, which necessitates the use of ARTs. The various forms of ARTs currently utilized in a clinical setting are addressed including history, preparations, and protocols for each technology. To promote continual advancement of the field, both animal studies and human trials provide fundamental stepping-stones towards the execution of new techniques and protocols. Examples of research conducted for the betterment of human reproductive medicine are explored, including an animal study conducted in mice exploring the role of tyramine in ovulation. With the development and implementation of new technologies and protocols in the field, this also unearths ethical dilemmas that further complicate the addition of new technologies in the field. Combining an extensive review in assisted reproduction, research and clinical fieldwork, this study investigates the history and development of novel research conducted in reproductive medicine and explores the broader implications of new technologies in the field.
ContributorsPeck, Shelbi Marie (Author) / Baluch, Debra P (Thesis advisor) / Maienschein, Jane (Thesis advisor) / Sweazea, Karen (Committee member) / Ellison, Karin (Committee member) / Arizona State University (Publisher)
Created2021
Description
Eusocial insect colonies have often been imagined as “superorganisms” exhibiting tight homeostasis at the colony level. However, colonies lack the tight spatial and organizational integration that many multicellular, unitary organisms exhibit. Precise regulation requires rapid feedback, which is often not possible when nestmates are distributed across space, making decisions asynchronously. Thus, one should expect poorer regulation in superorganisms than unitary organisms.Here, I investigate aspects of regulation in collective foraging behaviors that involve both slow and rapid feedback processes. In Chapter 2, I examine a tightly coupled system with near-instantaneous signaling: teams of weaver ants cooperating to transport massive prey items back to their nest. I discover that over an extreme range of scenarios—even up vertical surfaces—the efficiency per transporter remains constant. My results suggest that weaver ant colonies are maximizing their total intake rate by regulating the allocation of transporters among loads. This is an exception that “proves the rule;” the ant teams are recapitulating the physical integration of unitary organisms.
Next, I focus on a process with greater informational constraints, with loose temporal and spatial integration. In Chapter 3, I measure the ability of solitarily foraging Ectatomma ruidum colonies to balance their collection of protein and carbohydrates given different nutritional environments. Previous research has found that ant species can precisely collect a near-constant ratio between these two macronutrients, but I discover these studies were using flawed statistical approaches. By developing a quantitative measure of regulatory effect size, I show that colonies of E. ruidum are relatively insensitive to small differences in food source nutritional content, contrary to previously published claims.
In Chapter 4, I design an automated, micro-RFID ant tracking system to investigate how the foraging behavior of individuals integrates into colony-level nutrient collection. I discover that spatial fidelity to food resources, not individual specialization on particular nutrient types, best predicts individual forager behavior. These findings contradict previously published experiments that did not use rigorous quantitative measures of specialization and confounded the effects of task type and resource location.
ContributorsBurchill, Andrew Taylor (Author) / Pavlic, Theodore P (Thesis advisor) / Pratt, Stephen C (Thesis advisor) / Hölldobler, Bert (Committee member) / Cease, Arianne (Committee member) / Berman, Spring (Committee member) / Arizona State University (Publisher)
Created2022
Description
Programmed cell death plays an important role in a variety of processes that promote the survival of the host organism. Necroptosis, a form of programmed cell death, occurs through a signaling pathway involving receptor-interacting serine-threonine protein kinase 3 (RIPK3). In response to vaccinia virus infection, necroptosis is induced through DNA-induced activator of interferon (DAI), which activates RIPK3, leading to death of the cell and thereby inhibiting further viral replication in host cells. DAI also localizes into stress granules, accumulations of mRNAs that have stalled in translation due to cellular stress. The toxin arsenite, a canonical inducer of stress granule formation, was used in this project to study necroptosis. By initiating necroptosis with arsenite and vaccinia virus, this research project investigated the roles of necroptosis proteins and their potential localization into stress granules. The two aims of this research project were to determine whether stress granules are important for arsenite- and virus-induced necroptosis, and whether the proteins DAI and RIPK3 localize into stress granules. The first aim was investigated by establishing a DAI and RIPK3 expression system in U2OS cells; arsenite treatment or vaccinia virus infection was then performed on the U2OS cells as well as on U2OSΔΔG3BP1/2 cells, which are not able to form stress granules. The second aim was carried out by designing fluorescent tagging for the necroptosis proteins in order to visualize protein localization with fluorescent microscopy. The results show that arsenite induces DAI-dependent necroptosis in U2OS cells and that this arsenite-induced necroptosis likely requires stress granules. In addition, the results show that vaccinia virus induces DAI-dependent necroptosis that also likely requires stress granules in U2OS cells. Furthermore, a fluorescent RIPK3 construct was created that will allowfor future studies on protein localization during necroptosis and can be used to answer questions regarding localization of necroptosis proteins into stress granules. This project therefore contributes to a greater understanding of the roles of DAI and RIPK3 in necroptosis, as well as the roles of stress granules in necroptosis, both of which are important in research regarding viral infection and cellular stress.
ContributorsGogerty, Carolina (Author) / Jacobs, Bertram (Thesis advisor) / Langland, Jeffrey (Committee member) / Jentarra, Garilyn (Committee member) / Arizona State University (Publisher)
Created2021
Description
Throughout western clarinet art music, there are not only a large number of great performers and classical works, but also a valuable body of literature that has laid a solid foundation for clarinet development and global dispersion. By contrast, Chinese clarinet literature is lacking in quantity and global distribution. However, this is the first comprehensive study that discloses the mysterious mask of China’s clarinet art.
This study does not merely discuss the Chinese clarinet history, but it also introduces important historical events that influenced the development of the Chinese clarinet industry (excluding manufacturing), including Chinese military bands, clarinet music, pedagogy, clarinet figures, and its future direction.
In the conclusion of this paper, the author discusses the deficiency of the Chinese clarinet industry and makes suggestions for solving problems with clarinet players practicing more technique rather than focusing on musicianship, educators’ lack of concentration on teaching and academic research, and the shortage of Chinese clarinet works. Additionally, the author appeals to Chinese clarinet players to actively participate in international activities and the Chinese government to increase incentives to introduce high-level Chinese talents overseas to help make China a better country in any field.
This study does not merely discuss the Chinese clarinet history, but it also introduces important historical events that influenced the development of the Chinese clarinet industry (excluding manufacturing), including Chinese military bands, clarinet music, pedagogy, clarinet figures, and its future direction.
In the conclusion of this paper, the author discusses the deficiency of the Chinese clarinet industry and makes suggestions for solving problems with clarinet players practicing more technique rather than focusing on musicianship, educators’ lack of concentration on teaching and academic research, and the shortage of Chinese clarinet works. Additionally, the author appeals to Chinese clarinet players to actively participate in international activities and the Chinese government to increase incentives to introduce high-level Chinese talents overseas to help make China a better country in any field.
ContributorsZhu, Shuang (Author) / Spring, Robert S (Thesis advisor) / Gardner, Joshua T (Thesis advisor) / Wells, Christopher (Committee member) / Micklich, Albie (Committee member) / Schuring, Martin (Committee member) / Arizona State University (Publisher)
Created2017
Description
ABSTRACT
"The Soul Unto Itself," a chamber music song cycle, was commissioned by the author, Rosa LoGiudice, and composed by William Clay, a doctoral candidate in composition at Arizona State University. The cycle was conceived and composed in the summer and fall of 2019. The chamber ensemble was a sextet comprised of Megan Law, mezzo-soprano, Kristi Hanno, clarinet, Emilio Vazquez, violin, Rittika Gambhir, bassoon, Nathaniel De la Cruz, double bass, and Rosa LoGiudice, piano, all based in Tempe, Arizona. The song cycle was premiered in a lecture recital on December 8, 2019 at Hammer and Strings Conservatory in Gilbert, AZ.
"The Soul Unto Itself" is a cycle of six songs based on poems of Emily Dickinson. The poems all have common themes of personal transformation achieved through the introspective observations of the poet. An unusual chamber ensemble was chosen to include instruments not commonly used in vocal chamber music in order to create a greater variety of musical colors and timbres. This project included the creation of the musical score, a live performance that was video recorded, and the research paper. This document discusses the process of working with the composer, rehearsing the music as it was being composed, and negotiating revisions necessary to make the music more effective in performance. Each song is discussed in detail, especially the connection between the music and poetry, the overall form of the song, revisions discussed and implemented, and important motivic relationships between the songs that unify the cycle. In summary, the process of collaborating with a composer is a rewarding experience for both the performers and the composer, as everyone is challenged to improve their craft and overcome obstacles to achieve a successful performance.
"The Soul Unto Itself," a chamber music song cycle, was commissioned by the author, Rosa LoGiudice, and composed by William Clay, a doctoral candidate in composition at Arizona State University. The cycle was conceived and composed in the summer and fall of 2019. The chamber ensemble was a sextet comprised of Megan Law, mezzo-soprano, Kristi Hanno, clarinet, Emilio Vazquez, violin, Rittika Gambhir, bassoon, Nathaniel De la Cruz, double bass, and Rosa LoGiudice, piano, all based in Tempe, Arizona. The song cycle was premiered in a lecture recital on December 8, 2019 at Hammer and Strings Conservatory in Gilbert, AZ.
"The Soul Unto Itself" is a cycle of six songs based on poems of Emily Dickinson. The poems all have common themes of personal transformation achieved through the introspective observations of the poet. An unusual chamber ensemble was chosen to include instruments not commonly used in vocal chamber music in order to create a greater variety of musical colors and timbres. This project included the creation of the musical score, a live performance that was video recorded, and the research paper. This document discusses the process of working with the composer, rehearsing the music as it was being composed, and negotiating revisions necessary to make the music more effective in performance. Each song is discussed in detail, especially the connection between the music and poetry, the overall form of the song, revisions discussed and implemented, and important motivic relationships between the songs that unify the cycle. In summary, the process of collaborating with a composer is a rewarding experience for both the performers and the composer, as everyone is challenged to improve their craft and overcome obstacles to achieve a successful performance.
ContributorsLoGiudice, Rosa Mia (Author) / Campbell, Andrew (Thesis advisor) / Ryan, Russell (Committee member) / Rockmaker, Jody (Committee member) / Arizona State University (Publisher)
Created2020
Description
On a given night in 2018, over half a million people were experiencing homelessness in the United States, and of those, about 36,000 were youth under the age of 25. Music is an indispensable part of young people’s identities and cultures, and understanding the ways in which homeless youth define their own musical preferences and use of music can help music therapists intervene effectively in youth homelessness as part of an interdisciplinary care team. The purpose of this project was twofold: 1) to conduct a descriptive research project pertaining to homeless young adults’ use of music and 2) to develop recommendations for music therapists based on research findings from the descriptive project and extant literature. Thirty-one homeless young adults (ages 18-26) were recruited for interviews from two resource centers serving homeless youth in a large metropolitan city in a southwestern state. Template analysis was used to systematically analyze and code participants’ verbatim transcripts from the interviews into a codebook. Quotes from the interviews were used to illustrate themes. Findings included that homeless youth used music, especially metal and rap, for coping and mood regulation, and that youth are also engaged in creative music making, especially singing and songwriting for self-expression. For some youth, certain music can be identity-forming (for better or worse) and certain other music can be triggering. Results are integrated with a review of literature and recommendations for practicing clinicians are presented. Music therapy with this population would likely yield best outcomes by using short-term interventions and culturally competent application of clients’ preferred music.
ContributorsSample, Katherine Elizabeth (Author) / Belgrave, Melita (Thesis advisor) / Glidden-Tracey, Cynthia (Committee member) / Ferguson-Colvin, Kristin (Committee member) / Arizona State University (Publisher)
Created2019
Description
Lowell Liebermann (b.1961) is one of America’s most frequently performed contemporary composers. He has written a large number of piano pieces and his works are often featured in major competitions and doctoral dissertations. Liebermann’s relationship with the piano began early in life and he considers it to be his principal instrument. His understanding of the strengths and limitations of the piano makes his keyboard creations powerful, expressive, and virtuosic. Although many of his pieces have been performed, his Piano Sonata No. 3, Op. 82 has not yet found a large audience or used as the subject of in-depth discussion. It is the author’s hope to stimulate performances of this work through a descriptive analysis and performance guide. This research document begins with a concise biography of the composer, including the composer’s early musical experiences, his education in academia, and his composition career. The second chapter provides a review of the composer’s major works. The third chapter provides a descriptive analysis and performer’s guide, with insights into Liebermann’s expectations of the performer. The present study includes a lecture recital, found online at https://youtu.be/Uf-SpK8cIr0?si=usxy5_AaWu7VoKP4
ContributorsWei, Jialin (Author) / Meir, Baruch (Thesis advisor) / Hamilton, Robert (Thesis advisor) / Rockmaker, Jody (Committee member) / Arizona State University (Publisher)
Created2024
Description
Ge Gan-ru (b. 1954) is considered one of the most innovative composers of his time and is referred to in The New Grove Dictionary of Music and Musicians as “China's first avant-garde composer.”[ Stanley Sadie, The New Grove Dictionary of Music and Musicians, 2nd edition. Oxford: Oxford University Press,( January 29, 2004): 258.] In 1986, Ge composed Ancient Music, a piece employs extended piano techniques to express the composer's reimagination of ancient Chinese music.
This project explores the life and music of Ge Gan-ru by providing a historical background of Ge’s life as a composer during the Chinese Cultural Revolution[ The Chinese Cultural Revolution was a decade-long era of political and social upheaval ignited by Mao Zedong's attempt to restore his authority over the Communist Party through the mistreatment of the Chinese people. ] and the changes after he came to America. In addition, a technical analysis and performance guide of Ancient Music are included, in order to discuss how he expresses his individual compositional language and integrates Chinese musical concepts into a western contemporary compositional system. In this document, I take a close look at Ge Gan-ru’s perspectives on Chinese music and the revolutionary reforms he made. Chapter One is a review of sources about Ge’s life and study in China and America and a brief introduction to his Ancient Music. Chapter Two discusses why the concept of composer in the context of Western music is missing in Chinese music, as most traditional Chinese works were not created by a single person and therefore do not reflect the individual voice of one composer. This point can also be extended to explain why Chinese society has historically encouraged homogenization including in music. Chapter Three serves as a performance guide, as well as a musical and technical analysis of Ancient Music. This will involve outlining and comparing the performance of traditional Chinese instruments with the internal piano techniques employed throughout this piece. Chapter Four is a summary of Ge’s Ancient Music and his musical contributions.
ContributorsWang, Yun (Author) / Breslin, Cathal (Thesis advisor) / Solís, Ted (Committee member) / Creviston, Hannah (Committee member) / Arizona State University (Publisher)
Created2024
Description
Contraceptives are a vital part of reproductive care by preventing unwanted pregnancy, providing relief to premenstrual syndrome or PMS symptoms, and more. Birth control has been around for many centuries and has given women autonomy over their reproductive health. The Griswold v. Connecticut Supreme Court case in 1965 was the first ruling that made birth control accessible to the public under the law. However, this ruling only pertained only to married couples until the Eisenstadt v. Baird case in 1972. That case gave single women the ability to legally purchase contraceptives for themselves. In the decades since those rulings, many laws and policies have been put into place to give those in lower-income areas the ability to purchase contraceptives as well. With this increase in accessibility, those who use contraceptives, or are thinking of starting birth control, need to understand how to use it, when to use it, and the effects of using contraceptives. In the United States, nurses outnumber doctors by a 4:1 ratio and spend more time with patients than anyone else in a clinic or hospital environment. Nurses, being the main healthcare providers with whom a patient will interact, often are the ones patients ask questions about care and overall advice. Nurses must be able to relay valuable information about treatments or medicines, such as birth control, and give accurate information on the effects such treatments have. Nursing students need to be prepared. However, the amount of information provided, and opinions given might be affected by their nursing education, past experiences with birth control, and more. This project surveys nursing students at Arizona State University on their attitudes, behaviors, and beliefs towards birth control interventions, and how their individual experiences and education influence these perceptions.
ContributorsHiggins, Ilani Elyce (Author) / Gur-Arie, Rachel (Thesis advisor) / Ellison, Karin (Thesis advisor) / Maienschein, Jane (Committee member) / Arizona State University (Publisher)
Created2024
Description
Reactive oxygen species (ROS) including superoxide, hydrogen peroxide, and hydroxyl radicals occur naturally as a byproduct of aerobic respiration. To mitigate damages caused by ROS, Escherichia coli employs defenses including two cytosolic superoxide dismutases (SODs), which convert superoxide to hydrogen peroxide. Deletion of both sodA and sodB, the genes coding for the cytosolic SOD enzymes, results in a strain that is unable to grow on minimal medium without amino acid supplementation. Additionally, deletion of both cytosolic SOD enzymes in a background containing the relA1 allele, an inactive version of the relA gene that contributes to activation of stringent response by amino acid starvation, results in a strain that is unable to grow aerobically, even on rich medium. These observations point to a relationship between the stringent response and oxidative stress. To gain insight into this relationship, suppressors were isolated by growing the ∆sodAB relA1 cells aerobically on rich medium, and seven suppressors were further examined to characterize distinct colony sizes and temperature sensitivity phenotypes. In three of these suppressor-containing strains, the relA1 allele was successfully replaced by the wild type relA allele to allow further study in aerobic conditions. None of those three suppressors were found to increase tolerance to exogenous superoxides produced by paraquat, which shows that these mutations only overcome the superoxide buildup that naturally occurs from deletion of SODs. Because each of these suppressors had unique phenotypes, it is likely that they confer tolerance to SOD-dependent superoxide buildup by different mechanisms. Two of these three suppressors have been sent for whole-genome sequencing to identify the location of the suppressor mutation and determine the mechanism by which they confer superoxide tolerance.
ContributorsFlake, Melissa (Author) / Misra, Rajeev (Thesis advisor) / Shah, Dhara (Committee member) / Wang, Xuan (Committee member) / Arizona State University (Publisher)
Created2024