ASU Electronic Theses and Dissertations
This collection includes most of the ASU Theses and Dissertations from 2011 to present. ASU Theses and Dissertations are available in downloadable PDF format; however, a small percentage of items are under embargo. Information about the dissertations/theses includes degree information, committee members, an abstract, supporting data or media.
In addition to the electronic theses found in the ASU Digital Repository, ASU Theses and Dissertations can be found in the ASU Library Catalog.
Dissertations and Theses granted by Arizona State University are archived and made available through a joint effort of the ASU Graduate College and the ASU Libraries. For more information or questions about this collection contact or visit the Digital Repository ETD Library Guide or contact the ASU Graduate College at gradformat@asu.edu.
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- All Subjects: Drugs--Side effects.
- Creators: Davulcu, Hasan
Description
Proliferation of social media websites and discussion forums in the last decade has resulted in social media mining emerging as an effective mechanism to extract consumer patterns. Most research on social media and pharmacovigilance have concentrated on
Adverse Drug Reaction (ADR) identification. Such methods employ a step of drug search followed by classification of the associated text as consisting an ADR or not. Although this method works efficiently for ADR classifications, if ADR evidence is present in users posts over time, drug mentions fail to capture such ADRs. It also fails to record additional user information which may provide an opportunity to perform an in-depth analysis for lifestyle habits and possible reasons for any medical problems.
Pre-market clinical trials for drugs generally do not include pregnant women, and so their effects on pregnancy outcomes are not discovered early. This thesis presents a thorough, alternative strategy for assessing the safety profiles of drugs during pregnancy by utilizing user timelines from social media. I explore the use of a variety of state-of-the-art social media mining techniques, including rule-based and machine learning techniques, to identify pregnant women, monitor their drug usage patterns, categorize their birth outcomes, and attempt to discover associations between drugs and bad birth outcomes.
The technique used models user timelines as longitudinal patient networks, which provide us with a variety of key information about pregnancy, drug usage, and post-
birth reactions. I evaluate the distinct parts of the pipeline separately, validating the usefulness of each step. The approach to use user timelines in this fashion has produced very encouraging results, and can be employed for a range of other important tasks where users/patients are required to be followed over time to derive population-based measures.
Adverse Drug Reaction (ADR) identification. Such methods employ a step of drug search followed by classification of the associated text as consisting an ADR or not. Although this method works efficiently for ADR classifications, if ADR evidence is present in users posts over time, drug mentions fail to capture such ADRs. It also fails to record additional user information which may provide an opportunity to perform an in-depth analysis for lifestyle habits and possible reasons for any medical problems.
Pre-market clinical trials for drugs generally do not include pregnant women, and so their effects on pregnancy outcomes are not discovered early. This thesis presents a thorough, alternative strategy for assessing the safety profiles of drugs during pregnancy by utilizing user timelines from social media. I explore the use of a variety of state-of-the-art social media mining techniques, including rule-based and machine learning techniques, to identify pregnant women, monitor their drug usage patterns, categorize their birth outcomes, and attempt to discover associations between drugs and bad birth outcomes.
The technique used models user timelines as longitudinal patient networks, which provide us with a variety of key information about pregnancy, drug usage, and post-
birth reactions. I evaluate the distinct parts of the pipeline separately, validating the usefulness of each step. The approach to use user timelines in this fashion has produced very encouraging results, and can be employed for a range of other important tasks where users/patients are required to be followed over time to derive population-based measures.
ContributorsChandrashekar, Pramod Bharadwaj (Author) / Davulcu, Hasan (Thesis advisor) / Gonzalez, Graciela (Thesis advisor) / Hsiao, Sharon (Committee member) / Arizona State University (Publisher)
Created2016
Description
Online health forums provide a convenient channel for patients, caregivers, and medical professionals to share their experience, support and encourage each other, and form health communities. The fast growing content in health forums provides a large repository for people to seek valuable information. A forum user can issue a keyword query to search health forums regarding to some specific questions, e.g., what treatments are effective for a disease symptom? A medical researcher can discover medical knowledge in a timely and large-scale fashion by automatically aggregating the latest evidences emerging in health forums.
This dissertation studies how to effectively discover information in health forums. Several challenges have been identified. First, the existing work relies on the syntactic information unit, such as a sentence, a post, or a thread, to bind different pieces of information in a forum. However, most of information discovery tasks should be based on the semantic information unit, a patient. For instance, given a keyword query that involves the relationship between a treatment and side effects, it is expected that the matched keywords refer to the same patient. In this work, patient-centered mining is proposed to mine patient semantic information units. In a patient information unit, the health information, such as diseases, symptoms, treatments, effects, and etc., is connected by the corresponding patient.
Second, the information published in health forums has varying degree of quality. Some information includes patient-reported personal health experience, while others can be hearsay. In this work, a context-aware experience extraction framework is proposed to mine patient-reported personal health experience, which can be used for evidence-based knowledge discovery or finding patients with similar experience.
At last, the proposed patient-centered and experience-aware mining framework is used to build a patient health information database for effectively discovering adverse drug reactions (ADRs) from health forums. ADRs have become a serious health problem and even a leading cause of death in the United States. Health forums provide valuable evidences in a large scale and in a timely fashion through the active participation of patients, caregivers, and doctors. Empirical evaluation shows the effectiveness of the proposed approach.
This dissertation studies how to effectively discover information in health forums. Several challenges have been identified. First, the existing work relies on the syntactic information unit, such as a sentence, a post, or a thread, to bind different pieces of information in a forum. However, most of information discovery tasks should be based on the semantic information unit, a patient. For instance, given a keyword query that involves the relationship between a treatment and side effects, it is expected that the matched keywords refer to the same patient. In this work, patient-centered mining is proposed to mine patient semantic information units. In a patient information unit, the health information, such as diseases, symptoms, treatments, effects, and etc., is connected by the corresponding patient.
Second, the information published in health forums has varying degree of quality. Some information includes patient-reported personal health experience, while others can be hearsay. In this work, a context-aware experience extraction framework is proposed to mine patient-reported personal health experience, which can be used for evidence-based knowledge discovery or finding patients with similar experience.
At last, the proposed patient-centered and experience-aware mining framework is used to build a patient health information database for effectively discovering adverse drug reactions (ADRs) from health forums. ADRs have become a serious health problem and even a leading cause of death in the United States. Health forums provide valuable evidences in a large scale and in a timely fashion through the active participation of patients, caregivers, and doctors. Empirical evaluation shows the effectiveness of the proposed approach.
ContributorsLiu, Yunzhong (Author) / Chen, Yi (Thesis advisor) / Liu, Huan (Thesis advisor) / Li, Baoxin (Committee member) / Davulcu, Hasan (Committee member) / Arizona State University (Publisher)
Created2016