ASU Electronic Theses and Dissertations
This collection includes most of the ASU Theses and Dissertations from 2011 to present. ASU Theses and Dissertations are available in downloadable PDF format; however, a small percentage of items are under embargo. Information about the dissertations/theses includes degree information, committee members, an abstract, supporting data or media.
In addition to the electronic theses found in the ASU Digital Repository, ASU Theses and Dissertations can be found in the ASU Library Catalog.
Dissertations and Theses granted by Arizona State University are archived and made available through a joint effort of the ASU Graduate College and the ASU Libraries. For more information or questions about this collection contact or visit the Digital Repository ETD Library Guide or contact the ASU Graduate College at gradformat@asu.edu.
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- All Subjects: Peptide Array
- All Subjects: Remote Sensing Technology
Description
In the past half century, low-power wireless signals from portable radar sensors, initially continuous-wave (CW) radars and more recently ultra-wideband (UWB) radar systems, have been successfully used to detect physiological movements of stationary human beings.
The thesis starts with a careful review of existing signal processing techniques and state of the art methods possible for vital signs monitoring using UWB impulse systems. Then an in-depth analysis of various approaches is presented.
Robust heart-rate monitoring methods are proposed based on a novel result: spectrally the fundamental heartbeat frequency is respiration-interference-limited while its higher-order harmonics are noise-limited. The higher-order statistics related to heartbeat can be a robust indication when the fundamental heartbeat is masked by the strong lower-order harmonics of respiration or when phase calibration is not accurate if phase-based method is used. Analytical spectral analysis is performed to validate that the higher-order harmonics of heartbeat is almost respiration-interference free. Extensive experiments have been conducted to justify an adaptive heart-rate monitoring algorithm. The scenarios of interest are, 1) single subject, 2) multiple subjects at different ranges, 3) multiple subjects at same range, and 4) through wall monitoring.
A remote sensing radar system implemented using the proposed adaptive heart-rate estimation algorithm is compared to the competing remote sensing technology, a remote imaging photoplethysmography system, showing promising results.
State of the art methods for vital signs monitoring are fundamentally related to process the phase variation due to vital signs motions. Their performance are determined by a phase calibration procedure. Existing methods fail to consider the time-varying nature of phase noise. There is no prior knowledge about which of the corrupted complex signals, in-phase component (I) and quadrature component (Q), need to be corrected. A precise phase calibration routine is proposed based on the respiration pattern. The I/Q samples from every breath are more likely to experience similar motion noise and therefore they should be corrected independently. High slow-time sampling rate is used to ensure phase calibration accuracy. Occasionally, a 180-degree phase shift error occurs after the initial calibration step and should be corrected as well. All phase trajectories in the I/Q plot are only allowed in certain angular spaces. This precise phase calibration routine is validated through computer simulations incorporating a time-varying phase noise model, controlled mechanic system, and human subject experiment.
The thesis starts with a careful review of existing signal processing techniques and state of the art methods possible for vital signs monitoring using UWB impulse systems. Then an in-depth analysis of various approaches is presented.
Robust heart-rate monitoring methods are proposed based on a novel result: spectrally the fundamental heartbeat frequency is respiration-interference-limited while its higher-order harmonics are noise-limited. The higher-order statistics related to heartbeat can be a robust indication when the fundamental heartbeat is masked by the strong lower-order harmonics of respiration or when phase calibration is not accurate if phase-based method is used. Analytical spectral analysis is performed to validate that the higher-order harmonics of heartbeat is almost respiration-interference free. Extensive experiments have been conducted to justify an adaptive heart-rate monitoring algorithm. The scenarios of interest are, 1) single subject, 2) multiple subjects at different ranges, 3) multiple subjects at same range, and 4) through wall monitoring.
A remote sensing radar system implemented using the proposed adaptive heart-rate estimation algorithm is compared to the competing remote sensing technology, a remote imaging photoplethysmography system, showing promising results.
State of the art methods for vital signs monitoring are fundamentally related to process the phase variation due to vital signs motions. Their performance are determined by a phase calibration procedure. Existing methods fail to consider the time-varying nature of phase noise. There is no prior knowledge about which of the corrupted complex signals, in-phase component (I) and quadrature component (Q), need to be corrected. A precise phase calibration routine is proposed based on the respiration pattern. The I/Q samples from every breath are more likely to experience similar motion noise and therefore they should be corrected independently. High slow-time sampling rate is used to ensure phase calibration accuracy. Occasionally, a 180-degree phase shift error occurs after the initial calibration step and should be corrected as well. All phase trajectories in the I/Q plot are only allowed in certain angular spaces. This precise phase calibration routine is validated through computer simulations incorporating a time-varying phase noise model, controlled mechanic system, and human subject experiment.
ContributorsRong, Yu (Author) / Bliss, Daniel W (Thesis advisor) / Richmond, Christ D (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Alkhateeb, Ahmed (Committee member) / Arizona State University (Publisher)
Created2018
Description
Peptide microarrays have been used in molecular biology to profile immune responses and develop diagnostic tools. When the microarrays are printed with random peptide sequences, they can be used to identify antigen antibody binding patterns or immunosignatures. In this thesis, an advanced signal processing method is proposed to estimate epitope antigen subsequences as well as identify mimotope antigen subsequences that mimic the structure of epitopes from random-sequence peptide microarrays. The method first maps peptide sequences to linear expansions of highly-localized one-dimensional (1-D) time-varying signals and uses a time-frequency processing technique to detect recurring patterns in subsequences. This technique is matched to the aforementioned mapping scheme, and it allows for an inherent analysis on how substitutions in the subsequences can affect antibody binding strength. The performance of the proposed method is demonstrated by estimating epitopes and identifying potential mimotopes for eight monoclonal antibody samples.
The proposed mapping is generalized to express information on a protein's sequence location, structure and function onto a highly localized three-dimensional (3-D) Gaussian waveform. In particular, as analysis of protein homology has shown that incorporating different kinds of information into an alignment process can yield more robust alignment results, a pairwise protein structure alignment method is proposed based on a joint similarity measure of multiple mapped protein attributes. The 3-D mapping allocates protein properties into distinct regions in the time-frequency plane in order to simplify the alignment process by including all relevant information into a single, highly customizable waveform. Simulations demonstrate the improved performance of the joint alignment approach to infer relationships between proteins, and they provide information on mutations that cause changes to both the sequence and structure of a protein.
In addition to the biology-based signal processing methods, a statistical method is considered that uses a physics-based model to improve processing performance. In particular, an externally developed physics-based model for sea clutter is examined when detecting a low radar cross-section target in heavy sea clutter. This novel model includes a process that generates random dynamic sea clutter based on the governing physics of water gravity and capillary waves and a finite-difference time-domain electromagnetics simulation process based on Maxwell's equations propagating the radar signal. A subspace clutter suppression detector is applied to remove dominant clutter eigenmodes, and its improved performance over matched filtering is demonstrated using simulations.
The proposed mapping is generalized to express information on a protein's sequence location, structure and function onto a highly localized three-dimensional (3-D) Gaussian waveform. In particular, as analysis of protein homology has shown that incorporating different kinds of information into an alignment process can yield more robust alignment results, a pairwise protein structure alignment method is proposed based on a joint similarity measure of multiple mapped protein attributes. The 3-D mapping allocates protein properties into distinct regions in the time-frequency plane in order to simplify the alignment process by including all relevant information into a single, highly customizable waveform. Simulations demonstrate the improved performance of the joint alignment approach to infer relationships between proteins, and they provide information on mutations that cause changes to both the sequence and structure of a protein.
In addition to the biology-based signal processing methods, a statistical method is considered that uses a physics-based model to improve processing performance. In particular, an externally developed physics-based model for sea clutter is examined when detecting a low radar cross-section target in heavy sea clutter. This novel model includes a process that generates random dynamic sea clutter based on the governing physics of water gravity and capillary waves and a finite-difference time-domain electromagnetics simulation process based on Maxwell's equations propagating the radar signal. A subspace clutter suppression detector is applied to remove dominant clutter eigenmodes, and its improved performance over matched filtering is demonstrated using simulations.
ContributorsO'Donnell, Brian (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Bliss, Daniel (Committee member) / Johnston, Stephen A. (Committee member) / Kovvali, Narayan (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Arizona State University (Publisher)
Created2014