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There is a growing body of scientific evidence that the health of the microbiome (the trillions of microbes that inhabit the human host) plays an important role in maintaining the health of the host and that disruptions in the microbiome may play a role in certain disease processes. An increasing

There is a growing body of scientific evidence that the health of the microbiome (the trillions of microbes that inhabit the human host) plays an important role in maintaining the health of the host and that disruptions in the microbiome may play a role in certain disease processes. An increasing number of research studies have provided evidence that the composition of the gut (enteric) microbiome (GM) in at least a subset of individuals with autism spectrum disorder (ASD) deviates from what is usually observed in typically developing individuals. There are several lines of research that suggest that specific changes in the GM could be causative or highly associated with driving core and associated ASD symptoms, pathology, and comorbidities which include gastrointestinal symptoms, although it is also a possibility that these changes, in whole or in part, could be a consequence of underlying pathophysiological features associated with ASD. However, if the GM truly plays a causative role in ASD, then the manipulation of the GM could potentially be leveraged as a therapeutic approach to improve ASD symptoms and/or comorbidities, including gastrointestinal symptoms.

One approach to investigating this possibility in greater detail includes a highly controlled clinical trial in which the GM is systematically manipulated to determine its significance in individuals with ASD. To outline the important issues that would be required to design such a study, a group of clinicians, research scientists, and parents of children with ASD participated in an interdisciplinary daylong workshop as an extension of the 1st International Symposium on the Microbiome in Health and Disease with a Special Focus on Autism (www.microbiome-autism.com). The group considered several aspects of designing clinical studies, including clinical trial design, treatments that could potentially be used in a clinical trial, appropriate ASD participants for the clinical trial, behavioral and cognitive assessments, important biomarkers, safety concerns, and ethical considerations. Overall, the group not only felt that this was a promising area of research for the ASD population and a promising avenue for potential treatment but also felt that further basic and translational research was needed to clarify the clinical utility of such treatments and to elucidate possible mechanisms responsible for a clinical response, so that new treatments and approaches may be discovered and/or fostered in the future.

ContributorsFrye, Richard E. (Author) / Slattery, John (Author) / MacFabe, Derrick F. (Author) / Allen-Vercoe, Emma (Author) / Parker, William (Author) / Rodakis, John (Author) / Adams, James (Author) / Krajmalnik-Brown, Rosa (Author) / Bolte, Ellen (Author) / Kahler, Stephen (Author) / Jennings, Jana (Author) / James, Jill (Author) / Cerniglia, Carl E. (Author) / Midtvedt, Tore (Author) / Ira A. Fulton Schools of Engineering (Contributor)
Created2015-05-07
Description
A presentation describing technical work, community reaction and publicity associated with an online collection of Arizona Japanese-American internment camp newsletters and related archival materials developed in 2017. The presentation was given at the Arizona Library Association conference in October 2017 and this revised version was presented at the Arizona Archives

A presentation describing technical work, community reaction and publicity associated with an online collection of Arizona Japanese-American internment camp newsletters and related archival materials developed in 2017. The presentation was given at the Arizona Library Association conference in October 2017 and this revised version was presented at the Arizona Archives Summit on February 1, 2018.
ContributorsSpindler, Rob (Author)
Created2018-01-18
Description

Materials produced for the workshop hosted by the Humane Cities Initiative, Institute for Humanities Research, Arizona State University. Participants were sent this package of archival materials and links to brief online sources for advance readings. Also enclosed are PDF renderings of introductory powerpoint files by Spindler and Pagan, and an

Materials produced for the workshop hosted by the Humane Cities Initiative, Institute for Humanities Research, Arizona State University. Participants were sent this package of archival materials and links to brief online sources for advance readings. Also enclosed are PDF renderings of introductory powerpoint files by Spindler and Pagan, and an audio recording of the discussion joined in progress.

ContributorsSpindler, Rob (Compiler, Author) / Pagán, Eduardo Obregón, 1960- (Author)
Created2018-03-13
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Description

Presentation slides regarding the history of Victory Village, the trailer park built in 1945-46 to provide housing for WWII Veterans and their families at Arizona State University's Tempe campus. A presentation of research from University Archives records conducted in the summer of 2018. The presentation was videotaped as a lecture

Presentation slides regarding the history of Victory Village, the trailer park built in 1945-46 to provide housing for WWII Veterans and their families at Arizona State University's Tempe campus. A presentation of research from University Archives records conducted in the summer of 2018. The presentation was videotaped as a lecture for Professor Volker Benkert's online World War II history class.

ContributorsSpindler, Rob (Author)
Created2019-09-30
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Description

Powerpoint slides from Spindler's presentation at the 56th annual Arizona History Convention in Tucson, Arizona, April 24th, 2015. Details of the 1993-1995 U.S. District Court orders directing the corporate archives to Arizona State University and ASU's efforts to recover information from an obsolete digital imaging system are presented.

ContributorsSpindler, Rob (Author)
Created2015-04-24
DescriptionPowerpoint slides, audio clips and transcriptions from the presentation describing the work of Lincoln and Eleanor Ragsdale and civil rights actions at Phoenix from 1963-1964.
ContributorsSpindler, Rob (Author)
Created2017-02-18
Description

This research study will discover and evaluate information about existing crowdsourcing or participatory archives projects devoted to archival description, indexing or transcription. Many related projects that use crowdsourcing for collecting archival materials from the public are not specifically addressed here. In this research, the author has specifically sought evaluative information

This research study will discover and evaluate information about existing crowdsourcing or participatory archives projects devoted to archival description, indexing or transcription. Many related projects that use crowdsourcing for collecting archival materials from the public are not specifically addressed here. In this research, the author has specifically sought evaluative information about exemplary projects that can lead to useful specifications for a participatory archives system at Arizona State University Libraries.

ContributorsSpindler, Rob (Author)
Created2014-06-30
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Description

Presentation slides describing an Arizona Centennial project to build a digital library and facilitate community discussion about why people came to Arizona, why they stayed, and why they left. Presentation was made at Friendship Village, Tempe AZ, November 2011.

ContributorsSpindler, Rob (Author)
Created2011-10-31
Description

The Task Force of thirty faculty members and academic professionals was charged by the University Libraries and the Graduate College to "examine the potential for implementing a university program for Electronic Theses and Dissertations (ETDs). The Task Force was specifically asked to collect information about existing programs elsewhere, identify ASU

The Task Force of thirty faculty members and academic professionals was charged by the University Libraries and the Graduate College to "examine the potential for implementing a university program for Electronic Theses and Dissertations (ETDs). The Task Force was specifically asked to collect information about existing programs elsewhere, identify ASU graduate programs that could host pilot programs and prepare a comprehensive white paper..." with a recommended plan for implementation.

ContributorsSpindler, Rob (Compiler) / Losse, Deborah (Compiler)
Created2001-05-01