As much as SARS-CoV-2 has altered the way humans live since the beginning of 2020,<br/>this virus's deadly nature has required clinical testing to meet 2020's demands of higher<br/>throughput, higher accuracy and higher efficiency. Information technology has allowed<br/>institutions, like Arizona State University (ASU), to make strategic and operational changes to<br/>combat the SARS-CoV-2 pandemic. At ASU, information technology was one of the six facets<br/>identified in the ongoing review of the ASU Biodesign Clinical Testing Laboratory (ABCTL)<br/>among business, communications, management/training, law, and clinical analysis. The first<br/>chapter of this manuscript covers the background of clinical laboratory automation and details<br/>the automated laboratory workflow to perform ABCTL’s COVID-19 diagnostic testing. The<br/>second chapter discusses the usability and efficiency of key information technology systems of<br/>the ABCTL. The third chapter explains the role of quality control and data management within<br/>ABCTL’s use of information technology. The fourth chapter highlights the importance of data<br/>modeling and 10 best practices when responding to future public health emergencies.

As much as SARS-CoV-2 has altered the way humans live since the beginning of 2020, this virus's deadly nature has required clinical testing to meet 2020's demands of higher throughput, higher accuracy and higher efficiency. Information technology has allowed institutions, like Arizona State University (ASU), to make strategic and operational changes to combat the SARS-CoV-2 pandemic. At ASU, information technology was one of the six facets identified in the ongoing review of the ASU Biodesign Clinical Testing Laboratory (ABCTL) among business, communications, management/training, law, and clinical analysis. The first chapter of this manuscript covers the background of clinical laboratory automation and details the automated laboratory workflow to perform ABCTL’s COVID-19 diagnostic testing. The second chapter discusses the usability and efficiency of key information technology systems of the ABCTL. The third chapter explains the role of quality control and data management within ABCTL’s use of information technology. The fourth chapter highlights the importance of data modeling and 10 best practices when responding to future public health emergencies.

This project is designed as part of the multi-student ASU Biodesign Clinical Testing Laboratory (ABCTL) thesis project sponsored and organized by Dr. Carolyn Compton, professor of Life Sciences at ASU and medical director with the ABCTL. This project divides students into teams with Business, Law, Laboratory, IT, and Documentary focused groups, with the goal of providing a comprehensive overview of the operations of the ABCTL as a reference for other institutions and to produce a documentary film about the laboratory. As a member of the IT team, this writeup will focus on quality control throughout the transfer of data in the testing process, security and privacy of data, HIPAA and regulatory compliance, and accessibility of data while maintaining such restrictions.

As much as SARS-CoV-2 has altered the way humans live since the beginning of 2020, this virus's deadly nature has required clinical testing to meet 2020's demands of higher throughput, higher accuracy and higher efficiency. Information technology has allowed institutions, like Arizona State University (ASU), to make strategic and operational changes to combat the SARS-CoV-2 pandemic. At ASU, information technology was one of the six facets identified in the ongoing review of the ASU Biodesign Clinical Testing Laboratory (ABCTL) among business, communications, management/training, law, and clinical analysis. The first chapter of this manuscript covers the background of clinical laboratory automation and details the automated laboratory workflow to perform ABCTL’s COVID-19 diagnostic testing. The second chapter discusses the usability and efficiency of key information technology systems of the ABCTL. The third chapter explains the role of quality control and data management within ABCTL’s use of information technology. The fourth chapter highlights the importance of data modeling and 10 best practices when responding to future public health emergencies.

Eosinophilic Esophagitis, EoE, is a newer autoimmune chronic esophageal inflammatory illness that results from food allergen triggers (Lucendo, 2017). EoE has created a wide range of diagnostic challenges for physicians because of the similarities that it has compared to gastroesophageal reflux disease, GERD. Current research indicates that EoE predominately impacts males at higher rates compared to females, while White males are most affected by and at risk for developing EoE compared to people of other racial and ethnic backgrounds (Sperry, 2012). Despite these findings, there continues to be an absence of research on social factors and identities like gender, race, ethnicity, income, sexuality and more, that are neglected in understanding how these features interact with EoE. Thus, the purpose of this thesis was to provide more evidence on identity and social aspects in relation to EoE that remain ignored and explain why there might be difficulties in investigating these topics. Moreover, a survey was also developed in order to better understand the current EoE population between the ages of 18 to 26, in which the transition from pediatric to adult care occurs. Language has been shown to affect patient’s care and treatment regarding their health because of discriminations that patients have been subjected to in the past. Therefore, it is important to discuss the role played by language and political correctness, especially within surveys. This thesis will explore the depth of study that has been completed within neglected areas of research surrounding marginalized communities, while providing new insights and questions for future possible research regarding EoE. This will be accomplished by discussing the existing problems within each topic and draw conclusions as to why EoE research may have been hindered within these neglected subjects. This project will provide a literature review, survey development, and language strategies for conducting inclusive and diverse populations and research topics centered around EoE.

This Project Report documents the accomplishments of an extraordinary group of students, faculty, and staff at the Arizona state University, who participated in a year-long, multidisciplinary, first-of-its-kind academic endeavor entitled “The Making of a COVID Lab.” The lab that is the focus of this project is the ASU Biodesign Clinical Testing Laboratory, known simply as the ABCTL.

Under the direction of Dr. Carolyn Compton, a group of seven Barrett honors students have embarked on a truly unique team thesis project to create a documentary on the process of creating a COVID-19 testing laboratory. This documentary tells the story of the ASU Biodesign Clinical Testing Laboratory (ABCTL), the first lab in the western United States to offer public saliva testing to identify the presence of COVID-19.