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ASU BioDesign Clinical Testing Laboratory: The Making of a COVID Lab - Staying on Top of Evolving Best Practices for Testing and Intra-Organizational Communication

Description

The ASU BioDesign Clinical Testing Laboratory (ABCTL) was created to offer an accurate, less invasive, less labor intensive, and less resource draining public COVID-19 testing location in Arizona. The goal of this thesis project was to document the intra-organizational communication channels related to changing testing practices as the ABCTL evolved.…

The ASU BioDesign Clinical Testing Laboratory (ABCTL) was created to offer an accurate, less invasive, less labor intensive, and less resource draining public COVID-19 testing location in Arizona. The goal of this thesis project was to document the intra-organizational communication channels related to changing testing practices as the ABCTL evolved. This was done through a review of internal and external media, pressers, and an interview with Joshua LaBaer. By documenting internal communication channels, specifically those related to changes in testing, similar communication channels and results could be replicable in the future if an outside organization wished to transform an academic research lab into a viral testing facility.

ContributorsRaymond, Courtney (Author) / Compton, Carolyn (Thesis director) / Cheong, Pauline (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)

Created2021-05

Bringing Evidence Based Practice to Developing and Underprivileged Countries: A Focus on Women’s Health and Midwifery

Description

The SolarSPELL Health: Nursing and Midwifery library was created to provide health students and professionals in developing and underprivileged countries with resources for evidence based practice learning, and to help improve women’s health in the country with the highest maternal mortality rate in the world. Our team partnered with local…

The SolarSPELL Health: Nursing and Midwifery library was created to provide health students and professionals in developing and underprivileged countries with resources for evidence based practice learning, and to help improve women’s health in the country with the highest maternal mortality rate in the world. Our team partnered with local health schools to identify the greatest areas of need. The SolarSPELL team searched for open access materials aimed towards students and professionals in the health field, ensured that this content was relevant to the location and took into account the resources available, curated this content and ensured consistency throughout the process, and lastly packaged the material in a platform that was easy to access and navigate. South Sudan is the newest country in the world, and they lack significant resources, as do all of the countries that SolarSPELL serves. Receiving this library will allow the health students and professionals in South Sudan to utilize the resources they currently have, to provide evidenced based care, both saving and improving lives.

ContributorsRaymond, Courtney (Author) / Ross, Heather (Thesis director) / Hosman, Laura (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)

Created2020-12

Improving Maternal Health Outcomes in Developing and Under-Resourced Countries Through Women’s Empowerment and Increased Spousal Involvement

Description

The goal of this project was to create a quasi experimental study using an education module that teaches evidence-based practice methods. The theoretical frameworks used to create the educational content were the self-efficacy theory and the Health Belief Model. The evaluation methods used are based on the Kirkpatrick four level…

The goal of this project was to create a quasi experimental study using an education module that teaches evidence-based practice methods. The theoretical frameworks used to create the educational content were the self-efficacy theory and the Health Belief Model. The evaluation methods used are based on the Kirkpatrick four level model. An education module was created to be culturally and regionally relevant to South Sudan and Malawi. The education module was designed to be part of the SolarSPELL Health: Nursing and Midwifery Library. This was done by performing a literature review, curating resources, creating the educational materials, creating learning scenarios, curating relevant belief scales, and integrating the content into the SolarSPELL Health: Nursing and Midwifery Library. The on ground implementation of the materials was not a part of this project, but instead is planned for future research. This project creates a foundation from which SolarSPELL Health can implement the resources at a future date. In the long term, the goal of implementing the experiment is to improve maternal mental and physical health outcomes in South Sudan and Malawi, both of which have extremely high rates of maternal mortality and morbidity.

ContributorsRaymond, Courtney (Author) / Ross, Heather (Thesis advisor) / Hosman, Laura (Committee member) / Pepin, Susan (Committee member) / Arizona State University (Publisher)

Created2021

The Making of a COVID Lab Report

Description

This Project Report documents the accomplishments of an extraordinary group of students, faculty, and staff at the Arizona state University, who participated in a year-long, multidisciplinary, first-of-its-kind academic endeavor entitled “The Making of a COVID Lab.” The lab that is the focus of this project is the ASU Biodesign Clinical…

This Project Report documents the accomplishments of an extraordinary group of students, faculty, and staff at the Arizona state University, who participated in a year-long, multidisciplinary, first-of-its-kind academic endeavor entitled “The Making of a COVID Lab.” The lab that is the focus of this project is the ASU Biodesign Clinical Testing Laboratory, known simply as the ABCTL.

ContributorsCompton, Carolyn C. (Project director) / Christianson, Serena L. (Project director) / Floyd, Christopher (Project director) / Schneller, Eugene S (Research team head) / Rigoni, Adam (Research team head) / Stanford, Michael (Research team head) / Cheong, Pauline (Research team head) / McCarville, Daniel R. (Research team head) / Dudley, Sean (Research team head) / Blum, Nita (Research team head) / Magee, Mitch (Research team head) / Agee, Claire (Research team member) / Cosgrove, Samuel (Research team member) / English, Corinne (Research team member) / Mattson, Kyle (Research team member) / Qian, Michael (Research team member) / Espinoza, Hale Anna (Research team member) / Filipek, Marina (Research team member) / Jenkins, Landon James (Research team member) / Ross, Nathaniel (Research team member) / Salvatierra, Madeline (Research team member) / Serrano, Osvin (Research team member) / Wakefield, Alex (Research team member) / Calo, Van Dexter (Research team member) / Nofi, Matthew (Research team member) / Raymond, Courtney (Research team member) / Barwey, Ishna (Research team member) / Bruner, Ashley (Research team member) / Hymer, William (Research team member) / Krell, Abby Elizabeth (Research team member) / Lewis, Gabriel (Research team member) / Myers, Jack (Research team member) / Ramesh, Frankincense (Research team member) / Reagan, Sage (Research team member) / Kandan, Mani (Research team member) / Knox, Garrett (Research team member) / Leung, Michael (Research team member) / Schmit, Jacob (Research team member) / Woo, Sabrina (Research team member) / Anderson, Laura (Research team member) / Breshears, Scott (Research team member) / Majhail, Kajol (Research team member) / Ruan, Ellen (Research team member) / Smetanick, Jennifer (Research team member) / Bardfeld, Sierra (Research team member) / Cura, Joriel (Research team member) / Dholaria, Nikhil (Research team member) / Foote, Hannah (Research team member) / Liu, Tara (Research team member) / Raymond, Julia (Research team member) / Varghese, Mahima (Research team member)

Created2021

ASU Biodesign Clinical Testing Laboratory: Let's Go Save Some Lives

Description

Under the direction of Dr. Carolyn Compton, a group of seven Barrett honors students have embarked on a truly unique team thesis project to create a documentary on the process of creating a COVID-19 testing laboratory. This documentary tells the story of the ASU Biodesign Clinical Testing Laboratory (ABCTL), the…

Under the direction of Dr. Carolyn Compton, a group of seven Barrett honors students have embarked on a truly unique team thesis project to create a documentary on the process of creating a COVID-19 testing laboratory. This documentary tells the story of the ASU Biodesign Clinical Testing Laboratory (ABCTL), the first lab in the western United States to offer public saliva testing to identify the presence of COVID-19.

ContributorsCura, Joriel (Director, Photographer) / Foote, Hannah (Producer, Sound designer) / Raymond, Julia (Production personnel) / Bardfeld, Sierra (Narrator, Editor) / Dholaria, Nikhil (Writer of added commentary) / Liu, Tara (Writer of added commentary) / Varghese, Mahima (Writer of added commentary) / Compton, Carolyn C. (Interviewee, Project director) / Harris, Valerie (Interviewee) / LaBaer, Joshua (Interviewee) / Miceli, Joseph (Interviewee) / Nelson, Megan (Interviewee) / Ungaro, Brianna (Interviewee)

Created2021

Ketogenic Therapy as an Adjuvant for Malignant Glioma: Impacts on Anti-Tumor Immunity

Description

Malignant brain tumors are devastating despite aggressive treatments such as surgical resection, chemotherapy and radiation therapy. The average life expectancy of patients with newly diagnosed glioblastoma is approximately 15 months. One novel therapeutic strategy involves using a ketogenic diet (KD) which increases circulating ketones and reduces circulating glucose. While the…

Malignant brain tumors are devastating despite aggressive treatments such as surgical resection, chemotherapy and radiation therapy. The average life expectancy of patients with newly diagnosed glioblastoma is approximately 15 months. One novel therapeutic strategy involves using a ketogenic diet (KD) which increases circulating ketones and reduces circulating glucose. While the preclinical work has shown that the KD increases survival, enhances radiation and alters several pathways in malignant gliomas, its impact on the anti-tumor immune response has yet to be examined. This dissertation demonstrates that mice fed the KD had increased tumor-reactive innate and adaptive immune responses, including increased cytokine production and cytolysis via tumor-reactive CD8+ T cells. Additionally, we saw that mice maintained on the KD had increased CD4 infiltration, while T regulatory cell numbers stayed consistent. Lastly, mice fed the KD had a significant reduction in immune inhibitory receptor expression as well as decreased inhibitory ligand expression on glioma cells, namely programmed death receptor -1 (PD-1) and its ligand programmed death receptor ligand -1 (PD-L1). Further, it is demonstrated that the ketone body beta-hydroxybutyrate (BHB) reduces expression of PD-L1 on glioma cells in vitro suggesting it may be responsible in part for immune-related changes elicited by the KD. Finally this dissertation also shows that the KD increases the expression of microRNAs predicted to target PD-L1 suggesting a potential mechanism to explain the ability of the KD to modulate immune inhibitory checkpoint pathways. Taken together these studies shed important light on the mechanisms underlying the KD and provide additional support for its use an adjuvant therapy for malignant glioma.

ContributorsWoolf, Eric Christopher (Author) / Compton, Carolyn C. (Thesis advisor) / Scheck, Adrienne C (Committee member) / Preul, Mark C (Committee member) / Blattman, Joseph N (Committee member) / Mehta, Shwetal (Committee member) / Arizona State University (Publisher)

Created2018