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Description

In a recent opinion piece, Denis Duboule has claimed that the increasing shift towards systems biology is driving evolutionary and developmental biology apart, and that a true reunification of these two disciplines within the framework of evolutionary developmental biology (EvoDevo) may easily take another 100 years. He identifies methodological, epistemological,

In a recent opinion piece, Denis Duboule has claimed that the increasing shift towards systems biology is driving evolutionary and developmental biology apart, and that a true reunification of these two disciplines within the framework of evolutionary developmental biology (EvoDevo) may easily take another 100 years. He identifies methodological, epistemological, and social differences as causes for this supposed separation. Our article provides a contrasting view. We argue that Duboule’s prediction is based on a one-sided understanding of systems biology as a science that is only interested in functional, not evolutionary, aspects of biological processes. Instead, we propose a research program for an evolutionary systems biology, which is based on local exploration of the configuration space in evolving developmental systems. We call this approach—which is based on reverse engineering, simulation, and mathematical analysis—the natural history of configuration space. We discuss a number of illustrative examples that demonstrate the past success of local exploration, as opposed to global mapping, in different biological contexts. We argue that this pragmatic mode of inquiry can be extended and applied to the mathematical analysis of the developmental repertoire and evolutionary potential of evolving developmental mechanisms and that evolutionary systems biology so conceived provides a pragmatic epistemological framework for the EvoDevo synthesis.

ContributorsJaeger, Johannes (Author) / Laubichler, Manfred (Author) / Callebaut, Werner (Author) / College of Liberal Arts and Sciences (Contributor)
Created2015-02-17
Description

This research study will discover and evaluate information about existing crowdsourcing or participatory archives projects devoted to archival description, indexing or transcription. Many related projects that use crowdsourcing for collecting archival materials from the public are not specifically addressed here. In this research, the author has specifically sought evaluative information

This research study will discover and evaluate information about existing crowdsourcing or participatory archives projects devoted to archival description, indexing or transcription. Many related projects that use crowdsourcing for collecting archival materials from the public are not specifically addressed here. In this research, the author has specifically sought evaluative information about exemplary projects that can lead to useful specifications for a participatory archives system at Arizona State University Libraries.

ContributorsSpindler, Rob (Author)
Created2014-06-30
Description
A presentation describing technical work, community reaction and publicity associated with an online collection of Arizona Japanese-American internment camp newsletters and related archival materials developed in 2017. The presentation was given at the Arizona Library Association conference in October 2017 and this revised version was presented at the Arizona Archives

A presentation describing technical work, community reaction and publicity associated with an online collection of Arizona Japanese-American internment camp newsletters and related archival materials developed in 2017. The presentation was given at the Arizona Library Association conference in October 2017 and this revised version was presented at the Arizona Archives Summit on February 1, 2018.
ContributorsSpindler, Rob (Author)
Created2018-01-18
Description

Remarks offered at the Luhrs Reading Room, Hayden Library, Arizona State University on September 24, 2013 and at the Arizona Latino Art and Cultural Center, Phoenix, Arizona on September 26, 2013.

ContributorsSpindler, Rob (Author)
Created2013-09-24
Description

Historical research produced for a portion of the exhibit entitled Civil Rights in Arizona, which was displayed at the Luhrs Gallery, Hayden Library in 2012-2013. The action at the ROTC Building was one of the largest protests in Arizona State University history, resulting in the arrest of ten individuals. The

Historical research produced for a portion of the exhibit entitled Civil Rights in Arizona, which was displayed at the Luhrs Gallery, Hayden Library in 2012-2013. The action at the ROTC Building was one of the largest protests in Arizona State University history, resulting in the arrest of ten individuals. The second file, entitled "Who Were the Tempe Ten?", describes the arrested students and unaffiliated persons.

ContributorsSpindler, Rob (Curator)
Created2012
Description

Original exhibit panel text and an associated interview with ASU faculty Charles Backus and Harvey Bryan for the exhibit presented at the Luhrs Gallery, Hayden Library, Fall, 2013.

ContributorsSpindler, Rob (Curator) / Backus, Charles (Interviewee) / Bryan, Harvey (Interviewee)
Created2013-07-01
DescriptionThe Task Force was charged to devise a plan for phased electronic publication of periodicals and monographs produced by the Society of American Archivists. The report offered over fifty possible next steps and includes several appendices addressing specific sub-topics.
ContributorsSpindler, Rob (Contributor)
Created2002-12-10
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Description

Presentation slides describing an Arizona Centennial project to build a digital library and facilitate community discussion about why people came to Arizona, why they stayed, and why they left. Presentation was made at Friendship Village, Tempe AZ, November 2011.

ContributorsSpindler, Rob (Author)
Created2011-10-31
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Description

Brief overview presentation created for the Historical Department of the Salt River Project, Phoenix, Arizona, April 2012.

ContributorsSpindler, Rob (Author)
Created2012-04-23
Description

Presentation slides and variant presentation scripts for an overview of the Tempe Normal School as it was in 1912. Campus buildings, campus lands, academics, and student activities are featured.

ContributorsSpindler, Rob (Author)
Created2012-01