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On the island. As it is, plenty

ContributorsBritten, Benjamin, 1913-1976 (Composer)

On the island. Let the florid music praise!

ContributorsBritten, Benjamin, 1913-1976 (Composer)

Assessing the Influence of Automated Data Analytics on Cost and Schedule Performance

Description

This article assesses the combined influence of information integration and automated data analytics on project performance. To this end, retrospective data on 78 completed projects, with a total installed value of $8 billion, was collected. The data collection effort characterized, for each project, the level of internal and external information…

This article assesses the combined influence of information integration and automated data analytics on project performance. To this end, retrospective data on 78 completed projects, with a total installed value of $8 billion, was collected. The data collection effort characterized, for each project, the level of internal and external information integration. Information integration was assessed as the seamlessly interoperable sharing of data produced from a work function with other functions/stakeholders so that no manual data transfer was required. Also, the level of automated data analytics, understood as the full automation of the data analysis function after input data are entered, was also characterized on a project basis. Then, non-parametric statistical techniques were used to assess the impact of such functions on cost and schedule performance. The statistical analysis was also stratified by project type, e.g. greenfield and brownfield, additions, and modifications or shutdowns. Overall, projects with a sophisticated degree of information integration and automated data analytics can control their projects with more reliable information and in a proactive manner so that informed decisions can be timely made on behalf of the project and the organization.

ContributorsAbbaszadegan, Amin (Author) / Grau, David (Author) / Ira A. Fulton Schools of Engineering (Contributor)

Created2015-10-27

Design for Disassembly and Deconstruction: Challenges and Opportunities

Description

Construction waste management has become extremely important due to stricter disposal and landfill regulations, and a lesser number of available landfills. There are extensive works done on waste treatment and management of the construction industry. Concepts like deconstruction, recyclability, and Design for Disassembly (DfD) are examples of better construction waste…

Construction waste management has become extremely important due to stricter disposal and landfill regulations, and a lesser number of available landfills. There are extensive works done on waste treatment and management of the construction industry. Concepts like deconstruction, recyclability, and Design for Disassembly (DfD) are examples of better construction waste management methods. Although some authors and organizations have published rich guides addressing the DfD's principles, there are only a few buildings already developed in this area. This study aims to find the challenges in the current practice of deconstruction activities and the gaps between its theory and implementation. Furthermore, it aims to provide insights about how DfD can create opportunities to turn these concepts into strategies that can be largely adopted by the construction industry stakeholders in the near future.

ContributorsRios, Fernanda (Author) / Chong, Oswald (Author) / Grau, David (Author) / Julie Ann Wrigley Global Institute of Sustainability (Contributor)

Created2015-09-14

Optimizing a Point-of-Care Lateral Flow Assay for Measuring Eosinophil Peroxidase in the Esophageal String Test

Description

Background: Eosinophilic esophagitis (EoE) is an increasingly prevalent allergic disease characterized by eosinophilic inflammation and symptoms of esophageal dysfunction. Diagnosis and monitoring require repeated, invasive endoscopic esophageal biopsies to assess levels of eosinophilic inflammation. Recently, the minimally invasive esophageal string test (EST) has been used collect protein in mucosal secretions…

Background: Eosinophilic esophagitis (EoE) is an increasingly prevalent allergic disease characterized by eosinophilic inflammation and symptoms of esophageal dysfunction. Diagnosis and monitoring require repeated, invasive endoscopic esophageal biopsies to assess levels of eosinophilic inflammation. Recently, the minimally invasive esophageal string test (EST) has been used collect protein in mucosal secretions as a surrogate for tissue biopsies in monitoring disease activity. From the string, assessment of the eosinophil-associated proteins major basic protein-1 (MBP-1) and eotaxin-3 (Eot3) is used to assess disease activity; however, this requires measurement in a reference laboratory, for which the turnaround time for results exceeds the time required for histopathologic assessment of endoscopic biopsies. In addition, MBP-1 and Eot3 are not markers unique to eosinophils. These obstacles can be overcome by targeting eosinophil peroxidase (EPX), an eosinophil-specific protein, using a rapid point-of-care test. Currently, EPX is measured by a labor-intensive enzyme-linked immunosorbent assay (ELISA), but we sought to optimize a rapid point-of-care test to measure EPX in EST segments. Methods: We extracted protein from residual EST segments and measured EPX levels by ELISA and a lateral flow assay (LFA). Results: EPX levels measured by LFA strongly correlated with those quantified by ELISA (rs = 0.90 {95% CI: 0.8283, 0.9466}). The EPX LFA is comparable to ELISA for measuring EPX levels in ESTs. Conclusions: The EPX LFA can provide a way to rapidly test EPX levels in ESTs in clinical settings and may serve as a valuable tool to facilitate diagnosis and monitoring of EoE.

ContributorsDao, Adelyn (Author) / Lake, Douglas (Thesis director) / Borges, Chad (Committee member) / Wright, Benjamin (Committee member) / Barrett, The Honors College (Contributor) / School of Molecular Sciences (Contributor) / School of Life Sciences (Contributor)

Created2024-05

Piloting a Brief Pragmatic Intervention to Promote Weight-Inclusive Primary Care

Description

This project challenges the prevailing weight-centric paradigm of present-day medicine which focuses on weight as a primary indicator of health. This study aimed to understand the impact of a brief pragmatic intervention to facilitate shifting healthcare providers' clinical conceptualization, attitudes, and practices from weight-centric to weight-inclusive care. A one-hour pragmatic…

This project challenges the prevailing weight-centric paradigm of present-day medicine which focuses on weight as a primary indicator of health. This study aimed to understand the impact of a brief pragmatic intervention to facilitate shifting healthcare providers' clinical conceptualization, attitudes, and practices from weight-centric to weight-inclusive care. A one-hour pragmatic training was composed and presented to providers at a community health clinic. The intervention highlighted the critical gap in our understanding of health and attempted to bring attention to the intricate web of factors that play into the complexity of weight. The education also provided specific tools that providers can put into practice to better cultivate weight-inclusive care. Mixed methods were used to evaluate the acceptability and efficacy of the intervention via changes in provider attitudes, treatment behaviors, and conceptualization of patient issues. Findings reveal modest differences from pre- to post-intervention as well as a notable disconnect among providers’ understanding and application of concepts. Participants expressed significant interest in the training and weight-inclusive care.

ContributorsZach, Rose (Author) / McEntee, Mindy (Thesis director) / May, Michelle (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)

Created2024-05

zach_spring_2024.pdf

ContributorsZach, Rose (Author) / McEntee, Mindy (Thesis director) / May, Michelle (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)

Created2024-05

zach_spring_2024_photo.jpg

ContributorsZach, Rose (Author) / McEntee, Mindy (Thesis director) / May, Michelle (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)

Created2024-05

Utilizing Self-lysis Salmonella as a Vaccine Delivery System to Target Cancer Tumor cells and Induce Apoptosis and Immune Response: A Focus on the Construction of the Suicide Vector

Description

Modified Salmonella strains and recombinant DNA in a plasmid are used to construct a Salmonella strain that is dependent on the experimentally inserted plasmid. This construction will be done via lab techniques such as polymerase chain reactions (PCR), transformation, and other means to create this construction. With future successful construction, the inhibition…

Modified Salmonella strains and recombinant DNA in a plasmid are used to construct a Salmonella strain that is dependent on the experimentally inserted plasmid. This construction will be done via lab techniques such as polymerase chain reactions (PCR), transformation, and other means to create this construction. With future successful construction, the inhibition of flagella assembly, within the tumor environment, and increased synthesis of flagellin will be possible. In the case that only assembly is prevented, then, the reliance on the lysis system to release flagellin into the tumor microenvironment will be used as a means to induce immune response. With the success of the self-lysis ability, these strains could be used to target these tumor cells to deliver anticancer material as a vaccine delivery system.

ContributorsShagi, Agnel (Author) / Kong, Wei (Thesis director) / Fu, Lingchen (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)

Created2024-05

Effect of woody-plant encroachment on livestock production in North and South America

Description

A large fraction of the world grasslands and savannas are undergoing a rapid shift from herbaceous to woody-plant dominance. This land-cover change is expected to lead to a loss in livestock production (LP), but the impacts of woody-plant encroachment on this crucial ecosystem service have not been assessed. We evaluate…

A large fraction of the world grasslands and savannas are undergoing a rapid shift from herbaceous to woody-plant dominance. This land-cover change is expected to lead to a loss in livestock production (LP), but the impacts of woody-plant encroachment on this crucial ecosystem service have not been assessed. We evaluate how tree cover (TC) has affected LP at large spatial scales in rangelands of contrasting social–economic characteristics in the United States and Argentina. Our models indicate that in areas of high productivity, a 1% increase in TC results in a reduction in LP ranging from 0.6 to 1.6 reproductive cows (Rc) per km[superscript 2]. Mean LP in the United States is 27 Rc per km[superscript 2], so a 1% increase in TC results in a 2.5% decrease in mean LP. This effect is large considering that woody-plant cover has been described as increasing at 0.5% to 2% per y. On the contrary, in areas of low productivity, increased TC had a positive effect on LP. Our results also show that ecological factors account for a larger fraction of LP variability in Argentinean than in US rangelands. Differences in the relative importance of ecological versus nonecological drivers of LP in Argentina and the United States suggest that the valuation of ecosystem services between these two rangelands might be different. Current management strategies in Argentina are likely designed to maximize LP for various reasons we are unable to explore in this effort, whereas land managers in the United States may be optimizing multiple ecosystem services, including conservation or recreation, alongside LP.

ContributorsAnadon, Jose Daniel (Author) / Sala, Osvaldo (Author) / Turner II, B. L. (Author) / Bennett, Elena M. (Author) / College of Liberal Arts and Sciences (Contributor) / School of Life Sciences (Contributor) / Julie Ann Wrigley Global Institute of Sustainability (Contributor) / School of Sustainability (Contributor) / School of Geographical Sciences and Urban Planning (Contributor)

Created2014-09-02

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