Matching Items (37)
Description
This dissertation investigates the condition of skeletal muscle insulin resistance using bioinformatics and computational biology approaches. Drawing from several studies and numerous data sources, I have attempted to uncover molecular mechanisms at multiple levels. From the detailed atomistic simulations of a single protein, to datamining approaches applied at the systems biology level, I provide new targets to explore for the research community. Furthermore I present a new online web resource that unifies various bioinformatics databases to enable discovery of relevant features in 3D protein structures.
ContributorsMielke, Clinton (Author) / Mandarino, Lawrence (Committee member) / LaBaer, Joshua (Committee member) / Magee, D. Mitchell (Committee member) / Dinu, Valentin (Committee member) / Willis, Wayne (Committee member) / Arizona State University (Publisher)
Created2013
Description
While exercising mammalian muscle increasingly relies on carbohydrates for fuel as aerobic exercise intensity rises above the moderate range, flying birds are extraordinary endurance athletes and fuel flight, a moderate-high intensity exercise, almost exclusively with lipid. In addition, Aves have long lifespans compared to weight-matched mammals. As skeletal muscle mitochondria account for the majority of oxygen consumption during aerobic exercise, the primary goal was to investigate differences in isolated muscle mitochondria between these species and to examine to what extent factors intrinsic to mitochondria may account for the behavior observed in the intact tissue and whole organism. First, maximal enzyme activities were assessed in sparrow and rat mitochondria. Citrate synthase and aspartate aminotransferase activity were higher in sparrow compared to rat mitochondria, while glutamate dehydrogenase activity was lower. Sparrow mitochondrial NAD-linked isocitrate dehydrogenase activity was dependent on phosphate, unlike the mammalian enzyme. Next, the rate of oxygen consumption (JO), electron transport chain (ETC) activity, and reactive oxygen species (ROS) production were assessed in intact mitochondria. Maximal rates of fat oxidation were lower than for carbohydrate in rat but not sparrow mitochondria. ETC activity was higher in sparrows, but no differences were found in ROS production between species. Finally, fuel selection and control of respiration at three rates between rest and maximum were assessed. Mitochondrial fuel oxidation and selection mirrored that of the whole body; in rat mitochondria the reliance on carbohydrate increased as the rate of oxygen consumption increased, whereas fat dominated under all conditions in the sparrow. These data indicate fuel selection, at least in part, can be modulated at the level of the mitochondrial matrix when multiple substrates are present at saturating levels. As an increase in matrix oxidation-reduction potential has been linked to a suppression of fat oxidation and high ROS production, the high ETC activity relative to dehydrogenase activity in avian compared to mammalian mitochondria may result in lower matrix oxidation-reduction potential, allowing fatty acid oxidation to proceed while also resulting in low ROS production in vivo.
ContributorsKuzmiak, Sarah (Author) / Willis, Wayne T (Thesis advisor) / Mandarino, Lawrence (Committee member) / Sweazea, Karen (Committee member) / Harrison, Jon (Committee member) / Gadau, Juergen (Committee member) / Arizona State University (Publisher)
Created2012
Description
Website usage on both smartphone and tablet devices is rapidly increasing. Website success hinges largely upon how well information on the site is recalled and perceived. The purpose of this study is to explore the question of whether or not the differences in display size and resolution of smartphone versus tablet devices affect the recall of website information. I hypothesize that tablets will produce greater website recall than smartphones, due to their larger screen size and higher resolution which may reduce cognitive strain. During the study, participants viewed a sample website for two minutes on either an iPhone or iPad, and then participated in a brief 20 question memory test to evaluate how well they remembered the website information. Although test scores for the iPad users were about one test point higher than test scores for the iPhone users, the difference was not statistically significant. However, the study was limited by the low sample size (n = 94). This indicates that further research may find that tablets indeed allow for increased recall of certain kinds of website content.
ContributorsRaines, David Thomas (Author) / Martin, Judith (Thesis director) / Johnson, Kathryn (Committee member) / Wiedmaier, Benjamin (Committee member) / Barrett, The Honors College (Contributor) / Hugh Downs School of Human Communication (Contributor) / Department of Psychology (Contributor)
Created2013-05
Description
In this honors thesis certain religious and moral beliefs were analyzed and used to predict active euthanasia acceptance for Christians in the United States. The factors used to predict euthanasia acceptance for a suffering, terminally ill individual were religiosity, empathy, God representations, and attitudes toward God. Negative correlations were observed between acceptance of euthanasia and religiosity, empathy, positive attitudes toward God, and a benevolent God representation. Positive correlations were observed between acceptance of euthanasia and negative attitudes toward God, whereas there was no significant correlation between support for euthanasia and an authoritarian God representation. When acceptance of euthanasia was regressed on these independent variables, religiosity was the most significant predictor of acceptance. It was concluded that highly religious Christians may tend to prioritize their religious teachings over their instinctual empathy for a suffering person because prematurely ending a patient’s life interferes with God’s will and reduces his role in worldly affairs.
ContributorsAustin, Richard Vincent (Author) / Johnson, Kathryn (Thesis director) / Cohen, Adam (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Gift-giving economies are economic models that freely give resources rather than barter for them or purchase them from market. Need-based transfers fit into this economic model by freely giving resources on the basis of need, provided the giver can spare the resources. The Maasai are an East African pastoral tribe that practices need-based transfers through a tradition they call osotua. If they have a partner with an established osotua relationship, then they will give any amount of cattle that partner request, provided they can spare the cattle. Cheating each other is unheard of in this tradition, but for this simulation I am introducing cheating into this economic model through feigning need. If a cheater is not in need, they will act like they are in need. If they are in need, then the cheater will request more cattle than what they need to survive. I am testing two different responses to cheating: walking-away and punishing. In the walk-away condition, the victim ends their osotua partnership and establishes a new one. In the punishment condition, a portion of the cheater's stolen cattle is destroyed.
ContributorsDunkelberger, Sophia (Author) / Aktipis, Athena (Thesis director) / Presson, Clark (Committee member) / Johnson, Kathryn (Committee member) / School of Social and Behavioral Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Perceptions of the self differ between cultures, generally between those cultures in the West and East. Some of the ways that these individuals from these cultures may differ are in their self-construal, their collectivist and individualist tendencies, and how they perceive control in their lives. The current study proposes that some of these differences are influenced by different concepts individuals hold regarding the "soul", or inner self. These concepts may be promoted by the different religious beliefs prominent in different regions. The Soul Perception Index, being developed through this study, measures belief in multiple souls, a universal soul, a single soul, or no soul. It was predicted that a belief in a single soul will correlate with an individual view of the self (individualism, independent self-construal, internal locus of control), and a universal or multi-soul belief will correlate with an interdependent view of the self (collectivism, interdependent self-construal, and external locus of control). We found that these variables did not significantly differ in their relationships with soul belief. However, Indian Hindu participants and Chinese participants seemed to score highly on all self-view variables and all soul perception types indicating that individuals from these cultures may be more predisposed to hold opposing beliefs simultaneously while US Christians are not.
ContributorsNaidu, Esha Svetha (Author) / Cohen, Adam (Thesis director) / Glenberg, Arthur (Committee member) / Johnson, Kathryn (Committee member) / School of Historical, Philosophical and Religious Studies (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
This research examined the influence that Christian and Hindu religious beliefs have on environmentalism; specifically, whether beliefs that one would return to this earth after death (i.e., a belief in reincarnation) and how the world might end may explain more positive attitudes toward the environment. Participants were 533 self-identified Christians and Hindus in the United States and India who completed an online survey assessing religiosity, positive attitudes towards environmentalism, afterlife beliefs, and eschatological beliefs. Christians showed significantly lower ratings of environmentalism compared with Hindus. There were also significant negative differences found based on beliefs about heaven, eschatology beliefs, and increased religiosity in Christians, and significant positive differences found based on reincarnation, eschatology beliefs, and increased religiosity in Hindus. Overall, these results suggest that Christians are less likely to have positive attitudes toward environmentalism compared with Hindus, and that beliefs about the afterlife and the end of the world were significant predictors of environmentalist attitudes.
ContributorsParde, Madeline Morgan (Author) / Cohen, Adam (Thesis director) / Glenberg, Arthur (Committee member) / Johnson, Kathryn (Committee member) / Department of Psychology (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
For centuries, religion has been a part of people's lives, impacting their well-being. Well-being includes both positive and negative emotions that make people feel satisfied. Religion can affect how people handle their physical health, social behavior, support, and stress. Interestingly, more people have been abandoning religion since 1990, even though it has positive effects on well-being. In this study, I sought to understand the extent to which leaving religion is associated with all aspects of well-being, including spiritual well-being. I asked 606 Arizona State University undergraduates to rate their well-being from two different time periods in their life. Participants were first asked if they were currently religious or nonreligious;135 said they had left/changed religions. If participants indicated that they did not leave/change religions, they were asked about their well-being before and after starting at ASU. I examined perceived change in well-being to understand how religion can influence many aspects of an individual’s life. Leaving or changing religion was positively associated with well-being. Those who reported leaving religion reported better environmental, emotional, social, educational, occupational, and spiritual well-being. In the control group (ASU), educational and spiritual well-being had a significant increase, which is interesting. The results showed that changing/leaving religion had a positive association on well-being.
ContributorsCarbine, Analy (Author) / Cohen, Adam (Thesis director) / Corbin, William (Committee member) / Johnson, Kathryn (Committee member) / Barrett, The Honors College (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Department of Psychology (Contributor)
Created2023-12
Description
The future of driving is largely headed towards autonomous vehicles, and this is clear with companies such as Tesla, Waymo, and even tech giant Apple. Many professionals predict that autonomous vehicles will likely be commercially available and legal to use in some places by the late 2020s [15]. There are some benefits to the rapid development of autonomous vehicle controllers, such as more independence for those who can’t drive due to impairments, the potential for reduced traffic, as well as possibly decreasing the number of accidents. Though these are promising prospects, there are ethical concerns regarding the implementation of such technology. The goal of this thesis is to provide an introductory literature review that discusses the history of autonomous vehicles, different levels of autonomy, ethical considerations in autonomous systems, and prior work on characterizing human driving behaviors and implementing these behaviors with autonomous vehicle controllers. Finally, recommendations are proposed for data collection on human driving behaviors in an ongoing NSF-funded project at Arizona State University, “Embodiment of Human Values Profiles in Autonomous Vehicles via Psychomimetic Controller Design.”
ContributorsYoung, Brittine (Author) / Berman, Spring (Thesis director) / Johnson, Kathryn (Committee member) / Barrett, The Honors College (Contributor) / Department of Physics (Contributor) / Historical, Philosophical & Religious Studies, Sch (Contributor) / Mechanical and Aerospace Engineering Program (Contributor)
Created2022-05
Description
This dissertation describes a series of four studies on cognitive aging, working memory, and cognitive flexibility in dogs (Canis lupus familiaris) and their wild relatives. In Chapters 2 and 3, I designed assessments for age-related cognitive deficits in pet dogs which can be deployed rapidly using inexpensive and accessible materials. These novel tests can be easily implemented by owners, veterinarians, and clinicians and therefore, may improve care for elderly dogs by aiding in the diagnosis of dementia. In addition, these widely deployable tests may facilitate the use of dementia in pet dogs as a naturally occurring model of Alzheimer’s Disease in humans.In Chapters 4 and 5, I modified one of these tests to demonstrate for the first time that coyotes (Canis latrans) and wolves (Canis lupus lupus) develop age-related deficits in cognitive flexibility. This was an important first step towards differentiating between the genetic and environmental components of dementia in dogs and in turn, humans. Unexpectedly, I also detected cognitive deficits in young, adult dogs and wolves but not coyotes. These finding add to a recent shift in understanding cognitive development in dogs which may improve cognitive aging tests as well as training, care, and use of working and pet dogs. These findings also suggest that the ecology of coyotes may select for flexibility earlier in development.
In Chapter 5, I piloted the use of the same cognitive flexibility test for red and gray foxes so that future studies may test for lifespan changes in the cognition of small-bodied captive canids. More broadly, this paradigm may accommodate physical and behavioral differences between diverse pet and captive animals. In Chapters 4 and 5, I examined which ecological traits drive the evolution of behavioral flexibility and in turn, species resilience. I found that wolves displayed less flexibility than dogs and coyotes suggesting that species which do not rely heavily on unstable resources may be ill-equipped to cope with human habitat modification. Ultimately, this comparative work may help conservation practitioners to identify and protect species that cannot cope with rapid and unnatural environmental change.
ContributorsVan Bourg, Joshua (Author) / Wynne, Clive D (Thesis advisor) / Aktipis, C. Athena (Committee member) / Gilby, Ian C (Committee member) / Young, Julie K (Committee member) / Arizona State University (Publisher)
Created2022