Matching Items (11)
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- Creators: Barrett, The Honors College
- Creators: Frakes, David
Description
A cerebral aneurysm is a bulging of a blood vessel in the brain. Aneurysmal rupture affects 25,000 people each year and is associated with a 45% mortality rate. Therefore, it is critically important to treat cerebral aneurysms effectively before they rupture. Endovascular coiling is the most effective treatment for cerebral aneurysms. During coiling process, series of metallic coils are deployed into the aneurysmal sack with the intent of reaching a sufficient packing density (PD). Coils packing can facilitate thrombus formation and help seal off the aneurysm from circulation over time. While coiling is effective, high rates of treatment failure have been associated with basilar tip aneurysms (BTAs). Treatment failure may be related to geometrical features of the aneurysm. The purpose of this study was to investigate the influence of dome size, parent vessel (PV) angle, and PD on post-treatment aneurysmal hemodynamics using both computational fluid dynamics (CFD) and particle image velocimetry (PIV). Flows in four idealized BTA models with a combination of dome sizes and two different PV angles were simulated using CFD and then validated against PIV data. Percent reductions in post-treatment aneurysmal velocity and cross-neck (CN) flow as well as percent coverage of low wall shear stress (WSS) area were analyzed. In all models, aneurysmal velocity and CN flow decreased after coiling, while low WSS area increased. However, with increasing PD, further reductions were observed in aneurysmal velocity and CN flow, but minimal changes were observed in low WSS area. Overall, coil PD had the greatest impact while dome size has greater impact than PV angle on aneurysmal hemodynamics. These findings lead to a conclusion that combinations of treatment goals and geometric factor may play key roles in coil embolization treatment outcomes, and support that different treatment timing may be a critical factor in treatment optimization.
ContributorsIndahlastari, Aprinda (Author) / Frakes, David (Thesis advisor) / Chong, Brian (Committee member) / Muthuswamy, Jitendran (Committee member) / Arizona State University (Publisher)
Created2013
A level set approach for denoising and adaptively smoothing complex geometry stereolithography files
Description
Stereolithography files (STL) are widely used in diverse fields as a means of describing complex geometries through surface triangulations. The resulting stereolithography output is a result of either experimental measurements, or computer-aided design. Often times stereolithography outputs from experimental means are prone to noise, surface irregularities and holes in an otherwise closed surface.
A general method for denoising and adaptively smoothing these dirty stereolithography files is proposed. Unlike existing means, this approach aims to smoothen the dirty surface representation by utilizing the well established levelset method. The level of smoothing and denoising can be set depending on a per-requirement basis by means of input parameters. Once the surface representation is smoothened as desired, it can be extracted as a standard levelset scalar isosurface.
The approach presented in this thesis is also coupled to a fully unstructured Cartesian mesh generation library with built-in localized adaptive mesh refinement (AMR) capabilities, thereby ensuring lower computational cost while also providing sufficient resolution. Future work will focus on implementing tetrahedral cuts to the base hexahedral mesh structure in order to extract a fully unstructured hexahedra-dominant mesh describing the STL geometry, which can be used for fluid flow simulations.
A general method for denoising and adaptively smoothing these dirty stereolithography files is proposed. Unlike existing means, this approach aims to smoothen the dirty surface representation by utilizing the well established levelset method. The level of smoothing and denoising can be set depending on a per-requirement basis by means of input parameters. Once the surface representation is smoothened as desired, it can be extracted as a standard levelset scalar isosurface.
The approach presented in this thesis is also coupled to a fully unstructured Cartesian mesh generation library with built-in localized adaptive mesh refinement (AMR) capabilities, thereby ensuring lower computational cost while also providing sufficient resolution. Future work will focus on implementing tetrahedral cuts to the base hexahedral mesh structure in order to extract a fully unstructured hexahedra-dominant mesh describing the STL geometry, which can be used for fluid flow simulations.
ContributorsKannan, Karthik (Author) / Herrmann, Marcus (Thesis advisor) / Peet, Yulia (Committee member) / Frakes, David (Committee member) / Arizona State University (Publisher)
Created2014
Description
Cerebral aneurysms are pathological balloonings of blood vessels in the brain, commonly found in the arterial network at the base of the brain. Cerebral aneurysm rupture can lead to a dangerous medical condition, subarachnoid hemorrhage, that is associated with high rates of morbidity and mortality. Effective evaluation and management of cerebral aneurysms is therefore essential to public health. The goal of treating an aneurysm is to isolate the aneurysm from its surrounding circulation, thereby preventing further growth and rupture. Endovascular treatment for cerebral aneurysms has gained popularity over traditional surgical techniques due to its minimally invasive nature and shorter associated recovery time. The hemodynamic modifications that the treatment effects can promote thrombus formation within the aneurysm leading to eventual isolation. However, different treatment devices can effect very different hemodynamic outcomes in aneurysms with different geometries.
Currently, cerebral aneurysm risk evaluation and treatment planning in clinical practice is largely based on geometric features of the aneurysm including the dome size, dome-to-neck ratio, and parent vessel geometry. Hemodynamics, on the other hand, although known to be deeply involved in cerebral aneurysm initiation and progression, are considered to a lesser degree. Previous work in the field of biofluid mechanics has demonstrated that geometry is a driving factor behind aneurysmal hemodynamics.
The goal of this research is to develop a more combined geometric/hemodynamic basis for informing clinical decisions. Geometric main effects were analyzed to quantify contributions made by geometric factors that describe cerebral aneurysms (i.e., dome size, dome-to-neck ratio, and inflow angle) to clinically relevant hemodynamic responses (i.e., wall shear stress, root mean square velocity magnitude and cross-neck flow). Computational templates of idealized bifurcation and sidewall aneurysms were created to satisfy a two-level full factorial design, and examined using computational fluid dynamics. A subset of the computational bifurcation templates was also translated into physical models for experimental validation using particle image velocimetry. The effects of geometry on treatment were analyzed by virtually treating the aneurysm templates with endovascular devices. The statistical relationships between geometry, treatment, and flow that emerged have the potential to play a valuable role in clinical practice.
Currently, cerebral aneurysm risk evaluation and treatment planning in clinical practice is largely based on geometric features of the aneurysm including the dome size, dome-to-neck ratio, and parent vessel geometry. Hemodynamics, on the other hand, although known to be deeply involved in cerebral aneurysm initiation and progression, are considered to a lesser degree. Previous work in the field of biofluid mechanics has demonstrated that geometry is a driving factor behind aneurysmal hemodynamics.
The goal of this research is to develop a more combined geometric/hemodynamic basis for informing clinical decisions. Geometric main effects were analyzed to quantify contributions made by geometric factors that describe cerebral aneurysms (i.e., dome size, dome-to-neck ratio, and inflow angle) to clinically relevant hemodynamic responses (i.e., wall shear stress, root mean square velocity magnitude and cross-neck flow). Computational templates of idealized bifurcation and sidewall aneurysms were created to satisfy a two-level full factorial design, and examined using computational fluid dynamics. A subset of the computational bifurcation templates was also translated into physical models for experimental validation using particle image velocimetry. The effects of geometry on treatment were analyzed by virtually treating the aneurysm templates with endovascular devices. The statistical relationships between geometry, treatment, and flow that emerged have the potential to play a valuable role in clinical practice.
ContributorsNair, Priya (Author) / Frakes, David (Thesis advisor) / Vernon, Brent (Committee member) / Chong, Brian (Committee member) / Pizziconi, Vincent (Committee member) / Adrian, Ronald (Committee member) / Arizona State University (Publisher)
Created2016
Description
The purpose of this thesis was to explore how changes in the geometry of a bifurcating cerebral aneurysm will affect the hemodynamics in idealized models after stent treatment. This thesis explores the use of a computationally modeled Enterprise Vascular Reconstruction Device (Cordis, East Bridgewater, NJ), a high porosity and closed cell design. The models represent idealized cases of saccular aneurysms with dome sizes of either 4mm or 6mm and a dome to neck ratio of either 3:2 or 2:1. Two aneurysm contact angles are studied, one at 45 degrees and the other at 90 degrees. The stent was characterized and deployed with the use of Finite Element Analysis into each model. Computational Fluid Dynamic principles were applied in series of simulations on treated and untreated models. Data was gathered in the neck plane for the average velocity magnitude, root mean squared velocity, average flow vector angle of deflection, and the cross neck flow rate. Within the aneurysm, the average velocity magnitude, root mean squared velocity, and average pressure were calculated. Additionally, the mass flow rate at each outlet was recorded. The results of this study indicate that the Enterprise Stent was most effective in the sharper, 90 degree geometry of Model 3. Additionally, the stent had an adverse effect on the Models 1 and 4, which had the smallest neck sizes. Conclusions are that the Enterprise Stent, as a stand-alone treatment method is only reliable in situations that take advantage of its design.
ContributorsThomas, Kyle Andrew (Author) / Frakes, David (Thesis director) / LaBelle, Jeffrey (Committee member) / Babiker, Haithem (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2013-05
Description
This study investigates the application of Computational Fluid Dynamics (CFD) to the medical field. An overview of recent advances in computational simulation and modeling in medical applications is provided, with a particular emphasis on CFD. This study attempts to validate CFD and demonstrate the possibility for applying CFD to the clinical treatment and evaluation of atherosclerotic disease. Three different geometric configurations are investigated: one idealized bifurcation with a primary diameter of 8 mm, and two different patient-specific models of the bifurcation from the common femoral artery to the superficial and deep femoral arteries. CFD is compared against experimental measurements of steady state and pulsatile flow acquired with Particle Image Velocimetry (PIV). Steady state and pulsatile flow rates that are consistent with those observed in the femoral artery are used. In addition, pulsatile CFD simulations are analyzed in order to demonstrate meaningful clinical applications for studying and evaluating the treatment of atherosclerotic disease. CFD was successfully validated for steady state flow, with an average percent error of 6.991%. Potential for validation was also demonstrated for pulsatile flow, but methodological errors warrant further investigation to reformulate methods and analyze results. Quantities frequently associated with atherosclerotic disease and arterial bifurcations, such as large variations in wall shear stress and the presence of recirculation zones are demonstrated from the pulsatile CFD simulations. Further study is required in order to evaluate whether or not such phenomena are represented by CFD accurately. Further study must also be performed in order to evaluate the practicality and utility of CFD for the evaluation of atherosclerotic disease treatment.
ContributorsMortensen, Matthew James (Author) / VanAuker, Michael (Thesis director) / Frakes, David (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
This project is a synthesis of the author's learning over the semesters in working with the CFD Group at Arizona State University. The incompressible Navier-Stokes equations are overviewed, starting with the derivation from the continuity equation, then non-dimensionalization, methods of solving and computing quantities of interest. The rest of this document is expository analysis of solutions in a confined fluid flow, building toward a parametrically forced regime that generates complex flow patterns including Faraday waves. The solutions come from recently published studies Dynamics in a stably stratified tilted square cavity (Grayer et al.) and Parametric instabilities of a stratified shear layer (Buchta et al).
ContributorsBuchta, Matthew Ryan (Author) / Welfert, Bruno (Thesis director) / Yalim, Jason (Committee member) / Lopez, Juan (Committee member) / School of Mathematical and Statistical Sciences (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
Atomization of fluids inside combustion chamber has been a very complex and long-lasting subject that is still researched into for maximum efficiency in mixing oxidizer and fuel. This thesis focuses on an injector called the Liquid-Liquid Swirl Coaxial Injector (LLSC) to be used in a small-scale rocket engine due to its high efficiency in spray angles and low pressure drops. Injectors are the elements that exist as a connection in between the plumbing and the combustion chamber of the rocket engine. The performance of injectors can greatly affect the stability and efficiency of the engine. Injectors proportionally help breakup the fluid into small droplets that help in the efficiency of vaporization of fluids while combusting. Helios Rocketry, Arizona State University’s student-led engineering organization, is working to design and successfully launch a small-scale bi-propellant liquid rocket engine to a 100 km (Karman Line) in space as part of the Base11 challenge. For this task a highly efficient injector element needed to be designed that can achieve high amounts of atomization with a large spray angle, to help with combustion in a relatively small sized chamber. The purpose of this thesis is to explore a specific type of injector element called a LLSC injector element. This is performed by simulating it through an LES model in computational fluid dynamics using a Voronoi based meshing scheme, by using codes from Cascade Technologies. In the end a 35-injector element design was used for an injector plate. This helped minimize the pressure drop and keep the wall stress below the safety limit.
ContributorsDave, Himanshu Hitendra (Author) / Herrmann, Marcus (Thesis director) / Adrian, Ronald (Committee member) / Mechanical and Aerospace Engineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
An understanding of aerodynamics is crucial for automobile performance and efficiency. There are many types of “add-on” aerodynamic devices for cars including wings, splitters, and vortex generators. While these have been studied extensively, rear spoilers have not, and their effects are not as widely known. A Computational Fluid Dynamics (CFD) and wind tunnel study was performed to study the effects of spoilers on vehicle aerodynamics and performance. Vehicle aerodynamics is geometry dependent, meaning what applies to one car may or may not apply on another. So, the Scion FRS was chosen as the test vehicle because it is has the “classic” sports car configuration with a long hood, short rear, and 2+2 passenger cabin while also being widely sold with a plethora of aftermarket aerodynamic modifications available. Due to computing and licensing restrictions, only a 2D CFD simulation was performed in ANSYS Fluent 19.1. A surface model of the centerline of the car was created in SolidWorks and imported into ANSYS, where the domain was created. A mesh convergence study was run to determine the optimum mesh size, and Realizable k-epsilon was the chosen physics model. The wind tunnel lacked equipment to record quantifiable data, so the wind tunnel was utilized for flow visualization on a 1/24 scale car model to compare with the CFD.
0° spoilers reduced the wake area behind the car, decreasing pressure drag but also decreasing underbody flow, causing a reduction in drag and downforce. Angled spoilers increased the wake area behind the car, increasing pressure drag but also increasing underbody flow, causing an increase in drag and downforce. Longer spoilers increased these effects compared to shorter spoilers, and short spoilers at different angles did not create significantly different effects. 0° spoilers would be best suited for cases that prioritize fuel economy or straight-line acceleration and speed due to the drag reduction, while angled spoilers would be best suited for cars requiring downforce. The angle and length of spoiler would depend on the downforce needed, which is dependent on the track.
0° spoilers reduced the wake area behind the car, decreasing pressure drag but also decreasing underbody flow, causing a reduction in drag and downforce. Angled spoilers increased the wake area behind the car, increasing pressure drag but also increasing underbody flow, causing an increase in drag and downforce. Longer spoilers increased these effects compared to shorter spoilers, and short spoilers at different angles did not create significantly different effects. 0° spoilers would be best suited for cases that prioritize fuel economy or straight-line acceleration and speed due to the drag reduction, while angled spoilers would be best suited for cars requiring downforce. The angle and length of spoiler would depend on the downforce needed, which is dependent on the track.
ContributorsNie, Alexander (Author) / Wells, Valana (Thesis director) / Huang, Huei-Ping (Committee member) / Mechanical and Aerospace Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2019-12
Description
The dynamics of a stably and thermally stratified, two dimensional fluid-filled cavity are the subject of numerical study. When gravity is orthogonal to the endwalls, a closed form for a steady state solution with trivial flow may be obtained. However, as soon as the cavity is tilted the flow becomes nontrivial. Previous studies have investigated when this tilt angle is 180 degrees (Rayleigh-Bénard convection), 90 degrees, and 0 degrees, or have done a sweep while solving the steady-state equations. When buoyancy is sufficiently weak the flow is stable and steady up to 90 degrees of tilt. Above a certain level of buoyancy, as measured by the temperature difference between the top and bottom walls, the flow becomes unsteady above a tilt angle less than 90 degrees. Specifically, In this study we examine the relationship between the critical tilt angle and the buoyancy level at the onset of unsteadiness, as well as the dynamical mechanisms by which it occurs.
ContributorsGrayer, Hezekiah Villarin (Author) / Lopez, Juan M. (Thesis director) / Welfert, Bruno D. (Committee member) / Shen, Jie (Committee member) / Mechanical and Aerospace Engineering Program (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Competitive Swimming is not only a sport, but also an invaluable life skill. As long as it has existed, people have wondered how to swim faster. There are a multitude of variables that go into any race and shockingly not much research around to scientifically approach the question. This study aims to investigate the drag forces behind a Swimmer’s race to give better insight as to what will slow a Swimmer down through simulations in ANSYS Fluent. Simple 2D simulations were made with a Swimmer in different positions and a flow of water moved over them. What was found was that different positions, or techniques, yield vastly different results. When following typical good technique, a Swimmer can expect to be approximately 136% less drag forces compared to a typical bad technique. Additionally, small errors such as not being perfectly horizontal can lead to a difference of around 100 Newtons of drag force between perfectly horizontal and a 5-degree angle of attack. Another observation made was that errors are exacerbated by being near a wall, so Swimming in an end lane next to the pool wall leads to about 57% more drag forces that any other lane. Still, there are many more observations to be made as there is so much more to research in swimming.
ContributorsBenavidez, Kevin A (Author) / Murthy, Dr. Raghavendra (Thesis director) / Huang, Dr. Huei-Ping (Committee member) / Mechanical and Aerospace Engineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05