Matching Items (18)
Filtering by

Clear all filters

134152-Thumbnail Image.png
Description
Due to artificial selection, dogs have high levels of phenotypic diversity, yet, there appears to be low genetic diversity within individual breeds. Through their domestication from wolves, dogs have gone through a series of population bottlenecks, which has resulted in a reduction in genetic diversity, with a large amount of

Due to artificial selection, dogs have high levels of phenotypic diversity, yet, there appears to be low genetic diversity within individual breeds. Through their domestication from wolves, dogs have gone through a series of population bottlenecks, which has resulted in a reduction in genetic diversity, with a large amount of linkage disequilibrium and the persistence of deleterious mutations. This has led to an increased susceptibility to a multitude of diseases, including cancer. To study the effects of artificial selection and life history characteristics on the risk of cancer mortality, we collected cancer mortality data from four studies as well as the percent of heterozygosity, body size, lifespan and breed group for 201 dog breeds. We also collected specific types of cancer breeds were susceptible to and compared the dog cancer mortality patterns to the patterns observed in other mammals. We found a relationship between cancer mortality rate and heterozygosity, body size, lifespan as well as breed group. Higher levels of heterozygosity were also associated with longer lifespan. These results indicate larger breeds, such as Irish Water Spaniels, Flat-coated Retrievers and Bernese Mountain Dogs, are more susceptible to cancer, with lower heterozygosity and lifespan. These breeds are also more susceptible to sarcomas, as opposed to carcinomas in smaller breeds, such as Miniature Pinschers, Chihuahuas, and Pekingese. Other mammals show that larger and long-lived animals have decreased cancer mortality, however, within dog breeds, the opposite relationship is observed. These relationships could be due to the trade-off between cellular maintenance and growing fast and large, with higher expression of growth factors, such as IGF-1. This study further demonstrates the relationships between cancer mortality, heterozygosity, and life history traits and exhibits dogs as an important model organism for understanding the relationship between genetics and health.
ContributorsBalsley, Cassandra Sierra (Author) / Maley, Carlo (Thesis director) / Wynne, Clive (Committee member) / Tollis, Marc (Committee member) / School of Life Sciences (Contributor) / School of Human Evolution and Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12
147879-Thumbnail Image.png
Description

Extreme heat is the deadliest weather and climate-related hazard in the United States, and the threat it poses to urban residents is rising. City planners increasingly recognize these risks and are taking action to mitigate them. However, the COVID-19 pandemic has disrupted many plans. Building on a

Extreme heat is the deadliest weather and climate-related hazard in the United States, and the threat it poses to urban residents is rising. City planners increasingly recognize these risks and are taking action to mitigate them. However, the COVID-19 pandemic has disrupted many plans. Building on a previous survey which queried city planners from across the United States about how concerned they were about extreme heat, and their heat management efforts. This thesis examines how these perceptions and efforts have changed in the face of the COVID-19 pandemic. In general, it was found that public spaces which would typically have been used to shelter individuals from extreme heat conditions were closed to mitigate close-contact and to encourage social distancing. Furthermore, priorities were changed as the presence of the virus became commonplace, with plans being altered, delayed, or shelved to diverge more time and effort towards the crisis at hand. Working environments and conditions also changed, which in several cases led to technological shortcomings, resulting in further delays. Finally, most planners had attained a surface-level understanding of which socio-economic groups were most impacted by both COVID-19 and extreme heat, in congruence with the current literature written on the topic. Generally, it appears that planners feel that the impact of COVID-19 on heat planning efforts has been limited.

ContributorsNorris, Walker Yale (Author) / Meerow, Sara (Thesis director) / Keith, Ladd (Committee member) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
147895-Thumbnail Image.png
Description

For our project, we explored the growth of the ASU BioDesign Clinical Testing Laboratory (ABCTL) from a standard university research lab to a COVID-19 testing facility through a business lens. The lab has pioneered the saliva-test in the Western United States. This thesis analyzes the laboratory from various business concepts

For our project, we explored the growth of the ASU BioDesign Clinical Testing Laboratory (ABCTL) from a standard university research lab to a COVID-19 testing facility through a business lens. The lab has pioneered the saliva-test in the Western United States. This thesis analyzes the laboratory from various business concepts and aspects. The business agility of the lab and it’s quickness to innovation has allowed the lab to enjoy great success. Looking into the future, the laboratory has a promising future and will need to answer many questions to remain the premier COVID-19 testing institution in Arizona.

ContributorsEnglish, Corinne (Co-author) / Cosgrove, Samuel (Co-author) / Mattson, Kyle (Co-author) / Agee, Claire (Co-author) / Qian, Michael (Co-author) / Compton, Carolyn (Thesis director) / Schneller, Eugene (Committee member) / Department of Information Systems (Contributor) / Department of Supply Chain Management (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
147630-Thumbnail Image.png
Description

This paper conducts an exploration of the election policy reaction to the COVID-19 pandemic within the United States. While living through and voting during the real-time events which took place during the COVID-19 Pandemic of 2020, it soon became evident that there was not enough experience from earlier election emergencies

This paper conducts an exploration of the election policy reaction to the COVID-19 pandemic within the United States. While living through and voting during the real-time events which took place during the COVID-19 Pandemic of 2020, it soon became evident that there was not enough experience from earlier election emergencies to properly ensure against voter disenfranchisement. Given the scope of the global pandemic and the speed with which policymakers had to act, there was very little time to properly prepare. There was also great contention regarding the legitimacy of election methods proposed to alleviate in-person election concerns, such as mail-in voting. The political battle between those who believed COVID-19 to be a grave concern against those who did not consider COVID-19 to be a legitimate threat towards their livelihoods also affected policymaking decisions. Policymakers were forced into a corner, as they experienced criticism for not enough government action, as well as disapproval on the actual regulation that came to pass. This paper therefore aims to understand what factors led to the decisions which shaped the election policy which occurred as a reaction to the COVID-19 pandemic during the election year of 2020. This analysis is conducted by considering the following: prior election emergency policy; the development of reactive election policy in March, proactive policy established for the August and November elections; and a review of voter disenfranchisement which occurred due to COVID-19.

ContributorsPorritt, Sierra Joy (Author) / Hoekstra, Valerie (Thesis director) / Gaona, William (Committee member) / School of Politics and Global Studies (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Sandra Day O'Connor College of Law (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
147776-Thumbnail Image.png
Description

The ongoing Global Coronavirus Pandemic has been upheaving social norms for over a<br/>year at this point. For countless people, our lives look very different at this point in time<br/>then they did before the pandemic began. Quarantine, Shelter in Place, Work from<br/>Home, and Online classes have led global populations to become

The ongoing Global Coronavirus Pandemic has been upheaving social norms for over a<br/>year at this point. For countless people, our lives look very different at this point in time<br/>then they did before the pandemic began. Quarantine, Shelter in Place, Work from<br/>Home, and Online classes have led global populations to become less active leading to<br/>an increase in sedentary lifestyles. The final impact of this consequence is unknown,<br/>but emerging studies have led to concrete evidence of decreased physical and mental<br/>wellbeing, particularly in children. VirusFreeSports was the brainchild of three ASU<br/>Honors students who sought to remedy these devastating consequences by creating<br/>environments where children can participate in sports and exercise safely, free of the<br/>threat COVID-19 or other transmissible illnesses. The ultimate goal for the project team<br/>was to build traction for their idea, which culminated in a video pitch sent to potential<br/>investors. Although largely created as an exercise and we did not create a full<br/>certification course, merely a prototype through a website with sample questions to<br/>gauge interest, the project was a success as a large target market for this product was<br/>identified that showed great promise. Our team believes that early entrance to the<br/>market, as well as the lack of any other competitors would give the team a tremendous<br/>advantage in creating an impactful and influential service.

ContributorsIsrael, Natasha Nicole (Co-author) / Tanveer, Samad (Co-author) / Vrbanac, Matthew (Co-author) / Bryne, Jared (Thesis director) / Lee, Chris (Committee member) / Kunowski, Jeff (Committee member) / Department of Finance (Contributor) / Dean, W.P. Carey School of Business (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

Agassiz’s desert tortoise (Gopherus agassizii) is a long-lived species native to the Mojave Desert and is listed as threatened under the US Endangered Species Act. To aid conservation efforts for preserving the genetic diversity of this species, we generated a whole genome reference sequence with an annotation based on dee

Agassiz’s desert tortoise (Gopherus agassizii) is a long-lived species native to the Mojave Desert and is listed as threatened under the US Endangered Species Act. To aid conservation efforts for preserving the genetic diversity of this species, we generated a whole genome reference sequence with an annotation based on deep transcriptome sequences of adult skeletal muscle, lung, brain, and blood. The draft genome assembly for G. agassizii has a scaffold N50 length of 252 kbp and a total length of 2.4 Gbp. Genome annotation reveals 20,172 protein-coding genes in the G. agassizii assembly, and that gene structure is more similar to chicken than other turtles. We provide a series of comparative analyses demonstrating (1) that turtles are among the slowest-evolving genome-enabled reptiles, (2) amino acid changes in genes controlling desert tortoise traits such as shell development, longevity and osmoregulation, and (3) fixed variants across the Gopherus species complex in genes related to desert adaptations, including circadian rhythm and innate immune response. This G. agassizii genome reference and annotation is the first such resource for any tortoise, and will serve as a foundation for future analysis of the genetic basis of adaptations to the desert environment, allow for investigation into genomic factors affecting tortoise health, disease and longevity, and serve as a valuable resource for additional studies in this species complex.

Data Availability: All genomic and transcriptomic sequence files are available from the NIH-NCBI BioProject database (accession numbers PRJNA352725, PRJNA352726, and PRJNA281763). All genome assembly, transcriptome assembly, predicted protein, transcript, genome annotation, repeatmasker, phylogenetic trees, .vcf and GO enrichment files are available on Harvard Dataverse (doi:10.7910/DVN/EH2S9K).

ContributorsTollis, Marc (Author) / DeNardo, Dale F (Author) / Cornelius, John A (Author) / Dolby, Greer A (Author) / Edwards, Taylor (Author) / Henen, Brian T. (Author) / Karl, Alice E. (Author) / Murphy, Robert W. (Author) / Kusumi, Kenro (Author)
Created2017-05-31
Description

The climate conversation is growing more important and necessary than ever. The media has a way of promoting a "doom and gloom" sentiment over conservation efforts and what the public has the power to do in terms of making a change. Now due to the effects of COVID-19 on the

The climate conversation is growing more important and necessary than ever. The media has a way of promoting a "doom and gloom" sentiment over conservation efforts and what the public has the power to do in terms of making a change. Now due to the effects of COVID-19 on the population's attention spans and memories, there is a need for a way to communicate climate science effectively and to encourage those who feel discouraged by climate change to find their inner power. The answer lies in photography. Making science accessible and intriguing through the art of photography is what can get people more interested and empowered to fight against climate change and alter their attitudes towards environmentalism. This thesis explains psychological research and the reasons why people feel helpless in terms of our global future. In then dives into human subjects research conducted on ASU's campus and how the survey results argue in favor of the paper's hypothesis. Additionally, ways to get involved and reasons why we need to remain hopeful are discussed.

ContributorsGorlick, Vanessa (Author) / Hall, Sharon (Thesis director) / Makings, Elizabeth (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / The Sidney Poitier New American Film School (Contributor) / Dean, W.P. Carey School of Business (Contributor)
Created2023-05
131218-Thumbnail Image.png
Description
My journey through Arizona State University did not start with Supply Chain Management. I began as a Finance Major, but something did not resonate with me. I eventually switched my major to Supply Chain Management in my Junior year, after taking Professor Eddie Davila’s SCM 300 course. The hands-on nature

My journey through Arizona State University did not start with Supply Chain Management. I began as a Finance Major, but something did not resonate with me. I eventually switched my major to Supply Chain Management in my Junior year, after taking Professor Eddie Davila’s SCM 300 course. The hands-on nature of supply chain management, as well as the broad range of industries it covered, got me hooked. For my alternative thesis, I had to attend four seminars for WPC supply faculty, then write summaries on them. I would then choose one of the four to further extrapolate on and do independent research. However, after attending only two, the COVID-19 outbreak occurred, leading to the cancellation of the remaining seminars. As a result, I was faced with two choices; abandon the thesis project entirely, or work with what I had. With the approval of my director, I decided on the following outline. The first part of this paper will summarize and reflect on the two faculty lectures I was able to attend. The second part of the paper will look at the way COVID-19 has impacted the supply chain of a local business, SilverTree Dentistry. I will use information gathered from the dental office, supplier sites, and online sources as well as from the two faculty lectures to develop a cohesive plan of potential action for SilverTree to better equip themselves and their supply chain to handle the COVID-19 pandemic, as well as how to respond as a small business in future times of crisis. This paper’s focus is on how small business supply chains are disrupted in their areas of supplier selection and supplier power, specifically how those areas affect the business’s spend.
ContributorsMladenov, Stefan Nikolaev (Author) / Oke, Adegoke (Thesis director) / Printezis, Antonios (Committee member) / Department of Supply Chain Management (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
132536-Thumbnail Image.png
Description
Human activity produces ambient noise that potentially alters species’ abilities to communicate with each other—among other impacts. Given that birds are known to be sensitive to structural changes in habitat and highly communicative through sound, it is beneficial to understand how changing acoustic ecologies and ambient noise impact birds’

Human activity produces ambient noise that potentially alters species’ abilities to communicate with each other—among other impacts. Given that birds are known to be sensitive to structural changes in habitat and highly communicative through sound, it is beneficial to understand how changing acoustic ecologies and ambient noise impact birds’ ability to communicate in their respective environments. In this study, mockingbird calls from an urban, desert, and intermediate study site were recorded and analyzed for differences in acoustic properties. Acoustic properties such as frequency and amplitude differed significantly across sites as it was determined that mockingbirds in urban areas increase both the peak frequency and amplitude of their calls in order to communicate. This study identifies what these changes in acoustic properties mean in relation to the survival and conservation of birds and concludes with recommendations for novel research.
ContributorsReynolds, Bailey Susana (Author) / Pearson, David (Thesis director) / Walters, Molina (Committee member) / School of Sustainability (Contributor) / School of Life Sciences (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
130955-Thumbnail Image.png
DescriptionThis study was designed to evaluate the 2019 novel coronavirus (COVID-19) impact and its profound effect on the American oil industry.
ContributorsChow, Brandon Michael (Co-author) / Eberlein, Nikolas (Co-author) / LaRosa, Julia (Thesis director) / Fleischner, Rob (Committee member) / Dean, W.P. Carey School of Business (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-12