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Description
At present, the vast majority of human subjects with neurological disease are still diagnosed through in-person assessments and qualitative analysis of patient data. In this paper, we propose to use Topological Data Analysis (TDA) together with machine learning tools to automate the process of Parkinson’s disease classification and severity assessment. An automated, stable, and accurate method to evaluate Parkinson’s would be significant in streamlining diagnoses of patients and providing families more time for corrective measures. We propose a methodology which incorporates TDA into analyzing Parkinson’s disease postural shifts data through the representation of persistence images. Studying the topology of a system has proven to be invariant to small changes in data and has been shown to perform well in discrimination tasks. The contributions of the paper are twofold. We propose a method to 1) classify healthy patients from those afflicted by disease and 2) diagnose the severity of disease. We explore the use of the proposed method in an application involving a Parkinson’s disease dataset comprised of healthy-elderly, healthy-young and Parkinson’s disease patients.
ContributorsRahman, Farhan Nadir (Co-author) / Nawar, Afra (Co-author) / Turaga, Pavan (Thesis director) / Krishnamurthi, Narayanan (Committee member) / Electrical Engineering Program (Contributor) / Computer Science and Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Today's world is seeing a rapid technological advancement in various fields, having access to faster computers and better sensing devices. With such advancements, the task of recognizing human activities has been acknowledged as an important problem, with a wide range of applications such as surveillance, health monitoring and animation. Traditional approaches to dynamical modeling have included linear and nonlinear methods with their respective drawbacks. An alternative idea I propose is the use of descriptors of the shape of the dynamical attractor as a feature representation for quantification of nature of dynamics. The framework has two main advantages over traditional approaches: a) representation of the dynamical system is derived directly from the observational data, without any inherent assumptions, and b) the proposed features show stability under different time-series lengths where traditional dynamical invariants fail.
Approximately 1\% of the total world population are stroke survivors, making it the most common neurological disorder. This increasing demand for rehabilitation facilities has been seen as a significant healthcare problem worldwide. The laborious and expensive process of visual monitoring by physical therapists has motivated my research to invent novel strategies to supplement therapy received in hospital in a home-setting. In this direction, I propose a general framework for tuning component-level kinematic features using therapists’ overall impressions of movement quality, in the context of a Home-based Adaptive Mixed Reality Rehabilitation (HAMRR) system.
The rapid technological advancements in computing and sensing has resulted in large amounts of data which requires powerful tools to analyze. In the recent past, topological data analysis methods have been investigated in various communities, and the work by Carlsson establishes that persistent homology can be used as a powerful topological data analysis approach for effectively analyzing large datasets. I have explored suitable topological data analysis methods and propose a framework for human activity analysis utilizing the same for applications such as action recognition.
Approximately 1\% of the total world population are stroke survivors, making it the most common neurological disorder. This increasing demand for rehabilitation facilities has been seen as a significant healthcare problem worldwide. The laborious and expensive process of visual monitoring by physical therapists has motivated my research to invent novel strategies to supplement therapy received in hospital in a home-setting. In this direction, I propose a general framework for tuning component-level kinematic features using therapists’ overall impressions of movement quality, in the context of a Home-based Adaptive Mixed Reality Rehabilitation (HAMRR) system.
The rapid technological advancements in computing and sensing has resulted in large amounts of data which requires powerful tools to analyze. In the recent past, topological data analysis methods have been investigated in various communities, and the work by Carlsson establishes that persistent homology can be used as a powerful topological data analysis approach for effectively analyzing large datasets. I have explored suitable topological data analysis methods and propose a framework for human activity analysis utilizing the same for applications such as action recognition.
ContributorsVenkataraman, Vinay (Author) / Turaga, Pavan (Thesis advisor) / Papandreou-Suppappol, Antonia (Committee member) / Krishnamurthi, Narayanan (Committee member) / Li, Baoxin (Committee member) / Arizona State University (Publisher)
Created2016
Description
Over the past decade, machine learning research has made great strides and significant impact in several fields. Its success is greatly attributed to the development of effective machine learning algorithms like deep neural networks (a.k.a. deep learning), availability of large-scale databases and access to specialized hardware like Graphic Processing Units. When designing and training machine learning systems, researchers often assume access to large quantities of data that capture different possible variations. Variations in the data is needed to incorporate desired invariance and robustness properties in the machine learning system, especially in the case of deep learning algorithms. However, it is very difficult to gather such data in a real-world setting. For example, in certain medical/healthcare applications, it is very challenging to have access to data from all possible scenarios or with the necessary amount of variations as required to train the system. Additionally, the over-parameterized and unconstrained nature of deep neural networks can cause them to be poorly trained and in many cases over-confident which, in turn, can hamper their reliability and generalizability. This dissertation is a compendium of my research efforts to address the above challenges. I propose building invariant feature representations by wedding concepts from topological data analysis and Riemannian geometry, that automatically incorporate the desired invariance properties for different computer vision applications. I discuss how deep learning can be used to address some of the common challenges faced when working with topological data analysis methods. I describe alternative learning strategies based on unsupervised learning and transfer learning to address issues like dataset shifts and limited training data. Finally, I discuss my preliminary work on applying simple orthogonal constraints on deep learning feature representations to help develop more reliable and better calibrated models.
ContributorsSom, Anirudh (Author) / Turaga, Pavan (Thesis advisor) / Krishnamurthi, Narayanan (Committee member) / Spanias, Andreas (Committee member) / Li, Baoxin (Committee member) / Arizona State University (Publisher)
Created2020