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Description
The purpose of this project was to investigate the hypothesis that adults with dyslexia tend to have lower accuracies in and take longer to process tasks involving the serial order of letters, compared to age and gender-matched controls. In Experiment 1, participants evaluated word pairs for differences. Half of the word pairs that they evaluated were the same, whereas the remaining word pairs differed along specific parameters such as sequential rearrangements ("left" vs "felt"), left/right reversals ("cob" vs "cod"), up/down reversals ("best" vs "pest"), homophones ("grown" vs "groan"), visual letter similarities ("tight" vs "fight"), and generic substitutions ("moan" vs "loan"). The response times and accuracies of both groups were recorded. In Experiment 2, the participants spelled single words to dictation using the spelling subtest from the Wechsler Individual Achievement Test\u2014II. Spelling errors were evaluated for errors such as sequential rearrangements, left/right reversals, homophones, substitutions, orthographic violations, omissions, and insertions. An example of a spelling error is the word "excitement" misspelled as "excietment", which involves a sequential rearrangement error. Another example is the word "apparently" misspelled as "aparently,", which involves an error of omission. Error frequencies within these error types for both groups were recorded. Experiment 3 evaluated whether left/right reversal errors during the letter-naming Rapid Automatized Naming and Rapid Alternating Stimulus (RAN/RAS) task were associated with left/right errors during word pair comparison and spelling and whether these visual reversal errors were also associated with errors of serial order. The group with dyslexia was split into two groups: group 1 included participants who did not make any left/right reversals during the RAN/RAS task and group 2 included participants who did make left/right reversals during the RAN/RAS task. The accuracies and reaction times of these three groups during the comparison and spelling assessments were recorded. The results of experiment 1 revealed that that adults with dyslexia had a significantly higher reaction time and lower accuracy during the sequential rearrangement and left/right reversal conditions. Experiment 2 demonstrated that the group with dyslexia made significantly more spelling errors during the homophone and omission conditions. The results of Experiment 3 showed associations between the sequential rearrangement and left/right conditions in both the word pair comparison and spelling task for participants with dyslexia who made left/right reversals during the RAN/RAS task. Overall, the participants with dyslexia who made left/right reversals during the RAN/RAS task seemed to have greater difficulty understanding the orientation of letters that occur on a horizontal plane, since this underlying pattern of errors was also seen throughout the spelling and word comparison tasks. These results show that left/right reversals and errors of serial order are evident in some, but not all adults with dyslexia. These errors may also characterize a distinct subtype of dyslexia. Further, errors of left/right reversal and serial order appear to be associated, so left/right reversals may represent a special form of serial order error that involves a change in the order of visual processing in the horizontal but not vertical axis of letter orientation.
ContributorsAlbert, Andria (Author) / Peter, Beate (Thesis director) / Gray, Shelley (Committee member) / School of International Letters and Cultures (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
Background: This paper details the development of screening and education tools for finding Social Determinants of Health (SDH) in Maricopa County’s vulnerable population. SDH is known as structural or physical differences that hinder everyone to have an equal opportunity for improved health, and one of the steps to overcome the differences is through understanding what SDHs are prevalent in the targeted community, so that the community can develop the needed resources. SDH screening process was developed in collaboration with Student Health Outreach for Wellness (SHOW), a student-run organization whose aim is to provide healthcare for underserved populations. SHOW has a unique multi-disciplinary approach of treating each of their patients, and this screening is planned to be implemented during the treatment.
Methods: A literature review was conducted and SDH screening tool were adapted from known SDH screeners, such as Health Leads, PRAPARE, and CLEAR, to fit to the general population that SHOW serves. Training was also developed to educate the student volunteers who will be conducting the SDH screening and included necessary education about the population and the importance of SDH in general. Training materials include a practice scenario, a resources guide, SMART goal sheet, an introduction to the resource guide, and a process flowchart.
Outcomes: This project consists of different versions of screening tools, a training presentation, activities, handouts, and implementation ideas required to succeed in accurate SDH determination.
Methods: A literature review was conducted and SDH screening tool were adapted from known SDH screeners, such as Health Leads, PRAPARE, and CLEAR, to fit to the general population that SHOW serves. Training was also developed to educate the student volunteers who will be conducting the SDH screening and included necessary education about the population and the importance of SDH in general. Training materials include a practice scenario, a resources guide, SMART goal sheet, an introduction to the resource guide, and a process flowchart.
Outcomes: This project consists of different versions of screening tools, a training presentation, activities, handouts, and implementation ideas required to succeed in accurate SDH determination.
ContributorsChung, Min Kyung Rebecca (Author) / Harrell, Liz (Thesis director) / Essary, Alison (Committee member) / Department of Psychology (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Cancer is a disease in which abnormal cells divide uncontrollably and destroy body tissue, and currently plagues today’s world. Carcinomas are cancers derived from epithelial cells and include breast and prostate cancer. Breast cancer is a type of carcinoma that forms in breast tissue cells. The tumor cells can be further categorized after testing the cells for the presence of certain molecules. Hormone receptor positive breast cancer includes the tumor cells with receptors that respond to the steroid hormones, estrogen and progesterone, or the peptide hormone, HER2. These forms of cancer respond well to chemotherapy and endocrine therapy. On the other hand, triple negative breast cancer (TNBC) is characterized by the lack of hormone receptor expression and tends to have a worse prognosis in women. Prostate cancer forms in the cells of the prostate gland and has been attributed to mutations in androgen receptor ligand specificity. In a subset of triple negative breast cancer, genetic expression profiling has found a luminal androgen receptor that is dependent on androgen signaling. TNBC has also been found to respond well to enzalutamide, a an androgen receptor inhibitor. As the gene of the androgen receptor, AR, is located on the X chromosome and expressed in a variety of tissues, the responsiveness of TNBC to androgen receptor inhibition could be due to the differential usage of isoforms - different gene mRNA transcripts that produce different proteins. Thus, this study analyzed differential gene expression and differential isoform usage between TNBC cancers – that do and do not express the androgen receptor – and prostate cancer in order to better understand the underlying mechanism behind the effectiveness of androgen receptor inhibition in TNBC. Through the analysis of differential gene expression between the TNBC AR+ and AR- conditions, it was found that seven genes are significantly differentially expressed between the two types of tissues. Genes of significance are AR and EN1, which was found to be a potential prognostic marker in a subtype of TNBC. While some genes are differentially expressed between the TNBC AR+ and AR- tissues, the differences in isoform expression between the two tissues do not reflect the difference in gene expression. We discovered 11 genes that exhibited significant isoform switching between AR+ and AR- TNBC and have been found to contribute to cancer characteristics. The genes CLIC1 and RGS5 have been found to help the rapid, uncontrolled growth of cancer cells. HSD11B2, IRAK1, and COL1Al have been found to contribute to general cancer characteristics and metastasis in breast cancer. PSMA7 has been found to play a role in androgen receptor activation. Finally, SIDT1 and GLYATL1 are both associated with breast and prostate cancers. Overall, through the analysis of differential isoform usage between AR+ and AR- samples, we uncovered differences that were not detected by a gene level differential expression analysis. Thus, future work will focus on analyzing differential gene and isoform expression across all types of breast cancer and prostate cancer to better understand the responsiveness of TNBC to androgen receptor inhibition.
ContributorsDeshpande, Anagha J (Author) / Wilson-Sayres, Melissa (Thesis director) / Buetow, Kenneth (Committee member) / Natri, Heini (Committee member) / School of Human Evolution & Social Change (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Childbirth, an essential stage of human life, has been carried out and treated differently in numerous ways throughout time. Although the overall method of birth is biologically the same, women and medical professionals in the United States in particular have changed how they view and manage childbirth over the past 70 years. Some of said changes are extensive and occurred more rapidly than one might typically expect for such a delicate and important stage of a woman‘s, and infant‘s, life. As consumerism, capitalism, and the courts have changed America‘s lifestyles, politics, and society, so too have they drastically affected the way we are conditioned to approach childbirth. More importantly, as society changes over time, the medical field and
methods of specialists also change, and although the benefits of these changes are challenged by some individuals, these procedures and recommendations from professionals inevitably affect us all. Methods and procedures of modern, medicalized childbirth, and even the significance placed on the event, are products of historical and cultural factors influenced by scientific and social trends. However, there exists a small and steadily growing number of women and families who choose to have their birth take place outside of the present societal norm, and consequently outside of hospitals. This group‘s existence and growth has been attributed to several factors, including changes in societal values, differentiation between different financial classes, and the
medicalization of childbirth. Although statistically a small percentage of the majority, these women who choose to give birth outside of a hospital exist amidst an immense ongoing controversy between gynecologists, physicians, mothers, and midwives regarding what options should be available when childbirth is undertaken in the United States.
methods of specialists also change, and although the benefits of these changes are challenged by some individuals, these procedures and recommendations from professionals inevitably affect us all. Methods and procedures of modern, medicalized childbirth, and even the significance placed on the event, are products of historical and cultural factors influenced by scientific and social trends. However, there exists a small and steadily growing number of women and families who choose to have their birth take place outside of the present societal norm, and consequently outside of hospitals. This group‘s existence and growth has been attributed to several factors, including changes in societal values, differentiation between different financial classes, and the
medicalization of childbirth. Although statistically a small percentage of the majority, these women who choose to give birth outside of a hospital exist amidst an immense ongoing controversy between gynecologists, physicians, mothers, and midwives regarding what options should be available when childbirth is undertaken in the United States.
ContributorsHernandez, Dustin (Author) / Nguyen, Christy (Author) / Koblitz, Ann (Thesis director) / Budolfson, Arthur (Committee member) / Walker, Shell (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / W. P. Carey School of Business (Contributor)
Created2012-12
Description
Patient-physician interactions are the cornerstone of healthcare delivery, with the potential to significantly influence patient outcomes and healthcare efficiency. The quality of patient-physician interactions is pivotal in facilitating efficient communication concerning patient care and treatment. This relationship impacts the patient's adherence to medical advice and trust in healthcare. Considering the diversity of the patient population, there are a multitude of pertinent variables to take into account, including but not limited to English proficiency, race, educational attainment, age, gender, and socioeconomic status. How do patient-physician communication patterns and demographic variables impact patient comprehension, perception of communication efficacy, and healthcare outcomes across diverse cultural, linguistic, and socioeconomic backgrounds? The purpose of this thesis is to comprehensively understand the characteristics underlying effective patient-physician communication and its impact on patient compliance, retention of medical information, and healthcare outcomes. By addressing racial, cultural, linguistic, and socioeconomic disparities in healthcare, the research aims to establish a universal foundation for augmenting patient-centered care. The methodology of this research included an extensive literature review, shadowing of clinical visits, and patient care, along with the distribution of a survey to patients to gain insight into their satisfaction with healthcare. Practical applications include the development of targeted interventions, communication training programs for healthcare providers, and the formulation of policies aimed at improving patient outcomes and healthcare system efficiency. This research paper investigates the impact of physician attitudes on patient understanding and overall health through a comprehensive analysis of survey data collected from 115 individuals attending various clinics. Our findings highlight the significance of quality healthcare delivery in fostering favorable patient experiences, with 63.5% of respondents rating their visits as excellent or very good. Effective communication emerges as a key determinant of patient satisfaction, with 64.4% of respondents rating communication as excellent or very good. However, a notable proportion of respondents (26.9%) rated their overall satisfaction as neutral or dissatisfied, indicating areas for improvement in patient satisfaction related to unaddressed concerns or inadequate communication. Gender-related concerns, reactive versus proactive medicine, mental health, and shared decision-making emerge as overlooked topics in current clinical practice. Our observations underscore the need for a holistic approach that addresses patients' psychosocial and emotional needs alongside medical concerns. Gender-related differences in care delivery are evident, with female patients reporting feeling dismissed or misunderstood by male doctors, particularly regarding issues related to pain or reproductive health. Female physicians are associated with a greater likelihood of receiving preventive counseling and gender-specific screening, highlighting the importance of gender diversity in healthcare. Furthermore, patients express frustration with a reactive approach to medicine, advocating for a higher focus on addressing the underlying causes of health issues rather than merely treating symptoms. Patients also desire more information about natural remedies and holistic treatment options, emphasizing the importance of incorporating these discussions into shared decision-making between doctors and patients. The study underscores the pivotal role of specific provider qualities such as communication, empathy, and attention to patient comfort in patient-centered care delivery. The comprehension and cooperation rating between the doctor and patient was 81.8% excellent and good with a remaining of 18.2% indicating the need for a more interactive visit. Based on the survey, the important qualities of a provider from highest to lowest ranking include: communication (listening and understanding), empathy and kindness, medical knowledge proficiency, and quality listening. Due to the heavy importance on communication, it is imperative for healthcare providers to gain the necessary skills to cater to and address many of the concerns of their patients outside of simple medical knowledge. Given the doctor explanation comprehension rating of 25.2% being somewhat clear and not so clear, it is necessary for providers to develop their patient communication skills to optimize patient satisfaction and compliance. Cultural competency emerges as a critical aspect of providing effective and equitable care to patients from diverse backgrounds. However, there are limitations to the study, including the relatively small sample size and potential response bias. The findings of this study provide valuable insights into the multifaceted nature of the doctor-patient interaction and underscore the importance of effective communication, patient-centered care, and shared decision-making in promoting positive patient outcomes. According to the patient experience survey, talking more in depth about the patient treatment plan and taking the time to display eagerness to help and be active in one’s health will significantly enhance visit satisfaction. In addition to patients' ratings of physician level of empathy and respect consisting of 93% of respondents as exceeded or met expectations, the patient confidence in their health situation out of 10 was 6 and above for 90 percent of the survey respondents. However, with the shared decision making rating, 28.3% of respondents felt being somewhat involved or a little involved in their own care. By addressing patient needs and preferences and fostering collaborative relationships between physicians and patients, healthcare providers can enhance patient satisfaction, adherence to treatment recommendations, and overall health outcomes.
ContributorsAbdul, Zahir (Author) / La Crosse, Amber (Co-author) / Agu, Nnenna (Thesis director) / Markabawi, Bashar (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / Department of Psychology (Contributor)
Created2024-05
Description
This study examines the complex relationship between depression and students' experiences in active learning science courses. We uncover the significant impact of depression on cognitive functioning, particularly affecting energy levels, motivation, and self-doubt, especially among women. Highlighting the intersectionality of gender and depression, we stress the need to address disparities and bolster confidence in academic settings.
ContributorsClark, Sarah (Author) / Cooper, Katelyn (Thesis director) / Brownell, Sara (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / Dean, The College of Liberal Arts and Sciences (Contributor)
Created2024-05
Description
The project investigates the differences in the left and right hemispheres during a sensory gating paradigm in people with dyslexia compared to neurotypicals. The sensory gating paradigm included repeated pure tones, and each response's negative amplitudes during the first and second tones were recorded. It was determined that the response to the second tone can predict the response to the second tone. Still, there was no significant difference between participants with dyslexia and controls in the gating magnitude. There were no significant results when determining if gamma and beta power could predict the level of gating magnitude.
ContributorsBienz, Owen (Author) / Peter, Beate (Thesis director) / Daliri, Ayoub (Committee member) / Kim, Yookyung (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2024-05
Description
The present study was conducted in order to better understand how stuttering appears in bilingual Spanish-English (SE) speakers in Arizona. The primary purpose was to determine whether the frequencies and types of speech disfluencies that are produced by bilingual speakers vary depending on the language they are speaking in. In addition, the study attempted to determine whether there exists a variation of the frequencies or types of speech disfluencies that are produced by a bilingual speaker based on their approximate dominance of the language they are speaking in. For the purpose of the study, two elementary school children (2 boys, 7 and 10 years old), who were identified as diagnosed stutterers by a speech-language pathologist (SLP), were recruited and interviewed for 45 minutes. The two participants were identified as typically fluent in both English and Spanish from conversations with their parents and the pre-interview parental questionnaire in which their level of exposure to and approximate competence in each language was established. The interviews consisted of a speech and reading portion in both English and Spanish, in which spontaneous and non-spontaneous speech data was recorded. The results of the study indicate that there does seem to be a difference in the frequencies and types of speech disfluencies that appear depending on the language that a bilingual individual is speaking in. Additionally, there seems to be a relationship between approximate language dominance and the types or frequencies of speech disfluencies that are produced, however further research is recommended on this topic with a larger sample size of participants.
ContributorsKhakhanova, Anastasiya (Author) / Gradoville, Michael (Thesis director) / Daliri, Ayoub (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / School of Life Sciences (Contributor)
Created2024-05
Description
This study evaluates the level of human papillomavirus (HPV) awareness and knowledge among students and healthcare workers at Arizona State University (ASU). The significance of understanding HPV awareness and knowledge is paramount in the context of global public health as HPV is the most commonly sexually transmitted infection (STI) in the United States and can cause various health conditions, most notably cervical cancer. This study employed an anonymous, cross-sectional survey design to test for HPV awareness and knowledge among ASU students and healthcare workers. It most notably found that while approximately 90% of students are aware of HPV as a potential STI, only 54% are aware that HPV can cause various warts, only 30% are aware that HPV can cause six types of cancers, only 61% have been and/or know someone who has been vaccinated against HPV, and 80% have never been tested for HPV. Data was unable to be collected from healthcare workers on campus due to logistical conflicts with ASU Health Services. Overall, the study showed general awareness of HPV among ASU students but less functional knowledge about HPV, such as the health conditions it can cause, that could play a part in prevention behaviors, most notably with getting vaccinated and tested. While this study is a good start and baseline for ASU, it should be noted that it may not be entirely reflective of the university as a whole due to the majority of participants being white, cis, and female, so future work for data collection and subsequent outreach prevention programs is recommended to be complete.
ContributorsEsquerra, Sebastian (Author) / Quezada, Blanca (Thesis director) / Leaver, Jill (Committee member) / Ackerley, Hunter (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2024-05
Description
The social determinants of drug use are critical factors that influence patterns of substance use across urban and rural populations. This paper explores these determinants by comparing the prevalence and types of drug use within these diverse environments, drawing upon data and insights from recent studies. In urban areas, the variety and availability of drugs, coupled with socioeconomic disparities and cultural diversity, lead to distinct patterns of drug use. Conversely, rural areas face challenges like limited healthcare access and higher rates of prescription opioid misuse, often exacerbated by economic and social isolation. Significant differences in the social fabric between urban and rural settings influence drug use behaviors. Urban environments, characterized by dense populations and a wide array of available substances, report higher incidences of cocaine, heroin, and synthetic drug use. These areas often benefit from more extensive healthcare services but also face challenges such as higher levels of homelessness and crime, influencing substance use patterns. In contrast, rural areas deal with issues such as limited healthcare services and greater social stigma, which can deter individuals from seeking help, thus perpetuating cycles of substance abuse. This study underscores the importance of understanding the social determinants of health as they pertain to drug use. Factors like socioeconomic status, education, age, religion, gender, and sexual orientation play significant roles in shaping these patterns. By addressing these root causes through targeted public health interventions and policies, it is possible to effectively mitigate the impact of drug use across both urban and rural landscapes. This approach not only aids in substance abuse prevention but also ensures that interventions are equitable and culturally sensitive, thereby improving public health outcomes for diverse populations. The findings highlight the need for comprehensive strategies that consider both the unique and shared challenges faced by urban and rural communities in managing drug use. This nuanced understanding is crucial for developing interventions that are not only effective but also inclusive, addressing the broader social and economic dynamics that contribute to substance abuse.
ContributorsBahl, Shivani (Author) / Smith, Lisa (Thesis director) / Daniulaityte, Raminta (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / School of Human Evolution & Social Change (Contributor)
Created2024-05