Heat shock factors (HSFs) are transcriptional regulators that play a crucial role in the cellular response to environmental stress, particularly heat stress. Understanding the evolution of HSFs can provide insights into the adaptation of organisms to their changing environments. This project explored the evolution of HSFs within tetrapods, a group of animals that includes amphibians, reptiles, turtles, and mammals. Through an analysis of the available genomic data and subsequent genomic methodologies, HSFs have undergone significant changes throughout tetrapod evolution, as evidenced by loss events observed in protein sequences of the species under examination. Moreover, several conserved and divergent regions within HSF proteins were identified, which may reflect functional differences between HSFs in different tetrapod lineages. Our findings suggest that the evolution of HSFs has contributed to the adaptation of tetrapods to their diverse environments and that further research on the functional and regulatory differences between HSFs may provide a better understanding of how organisms cope with stress in heat-stressed environments.

This thesis addresses the global and national health landscape of disparities to provide insight into the social factors such as education, socioeconomic status, and environment that impact marginalized groups. A positive correlation between race, residency, and lower socioeconomic status among global and national landscapes was made with oral health disparities demonstrating poorer health outcomes among these groups. Through a multistep approach this thesis aimed to provide solutions to contribute to the efforts of developing effective policies and interventions that aim to promote oral health equity.

Existing research has shown that both ethnic discrimination and household wealth can shape child well-being and development. However, little work examines ethnic discrimination and its relation to income in predicting childhood health globally. This study explores two possible explanations for disparities in infant mortality between ethnic groups across countries worldwide. The first is an explanation based on wealth differentials across ethnic groups. The second is the impact of forms of ethnic discrimination such as past lethal violence or forced labor experienced by the group. This study examines the correlation between ethnic discrimination and infant mortality using household wealth as a covariate. Analyses focused on 266 ethnicities in 40 low- and middle-income countries globally, drawing on infant mortality data from Demographic and Health Surveys and data on ethnic discrimination compiled by the Inclusive Human Learning Lab at Arizona State University. Findings without the inclusion of household wealth show that ethnic groups that predominantly spoke the state language had significantly lower rates of infant mortality. However, this trend disappears when income is added as a covariate. No other measures of discrimination or privilege were associated with infant mortality. Across all analyses, the wealth of the ethnic group was a significant predictor of infant mortality. Future studies should examine whether these trends persist in high-income countries, and whether the general lack of association of discrimination and privilege variables with infant mortality is influenced by how the variables were coded.

This study compares vaccine hesitancy during the COVID-19 pandemic with previous studies on vaccine hesitancy to evaluate the major driving factors behind COVID-19 vaccine hesitancy among undergraduate students at Arizona State University (ASU). Undergraduate students were surveyed with questions regarding different aspects of vaccines, including personal vaccination history, opinions on the COVID-19 vaccine, knowledge of the COVID-19 vaccine, and reasoning behind vaccination status. The survey was distributed through school listservs within ASU. Close-ended questions underwent statistical analysis on IBM SPSS and open-ended questions were analyzed using content analysis. Results indicated that the main driving factors behind vaccine hesitancy are believing in natural immunity, familial influence, lack of trust behind the technology of the COVID-19 vaccine, and preferring the risk of COVID-19 infection over the risk of COVID-19 vaccination. The main driving factors behind vaccine hesitancy appear to be similar to driving factors in the past, with an increase of mistrust surrounding the vaccine.

This thesis attempts to use psychoneuroimmunology (PNI) as a lens for examining different immune and autoimmune disorders, as well as psychological function and dysfunction. Through this examination, it is hypothesized that PNI could point to an accurate theoretical framework for describing the mind-body relation, or at the very least gain a deeper respect for showing the complexity of consciousness and health. Conversely, an appropriate view of the mind-body relation should provide a sound theoretical framework for PNI research.

This thesis explores the ethical implications of using facial recognition artificial intelligence (AI) technologies in medicine, with a focus on both the opportunities and challenges presented by the use of this technology in the diagnosis and treatment of rare genetic disorders. We highlight the positive outcomes of using AI in medicine, such as accuracy and efficiency in diagnosing rare genetic disorders, while also examining the ethical concerns including bias, misdiagnosis, the issues it may cause within patient-clinician relationships, misuses outside of medicine, and privacy. This paper draws on the opinions of medical providers and other professionals outside of medicine, which finds that while many are excited about the potential of AI to improve medicine, concerns remain about the ethical implications of these technologies. We discuss current legislation controlling the use of AI in healthcare and its ambiguity. Overall, this thesis highlights the need for further research and public discourse to address the ethical implications of using facial recognition and AI technologies in medicine, while also providing recommendations for its future use in medicine.

Health service quality is understood to be a crucial determinant in successful patient-physician encounters and patient health. One common feeling that patients have reported experiencing during appointments is shame. We hypothesized that patients who experience appearance-based shame during an appointment are not likely to return to the same physician and that patients who do not experience appearance-based shame are likely to return to the same physician. This was assessed by conducting an anonymous online survey of 13 questions that served to establish a general foundation for understanding the participants' physical characteristics such as race, age, weight, and gender identity as well as their overall patient-physician relationship and experiences of shame, if applicable. 119 participants were recruited from Arizona State University and a case study was performed individually for five participants of interest. The data analyzed from this study suggests that while appearance-based shame does exist in healthcare spaces, it is not a significant determining factor in patients returning to their physicians. In addition, there was no significant evidence to suggest that patients who do not experience appearance-based shame are either likely or more likely to return to their physician. We hypothesize this could be due to confounding variables such as convenience, accessibility, or insurance limitations which patients may prioritize over feeling ashamed during an appointment. However, more research needs to be conducted to confirm these hypotheses.

Our bodies are constantly fighting off viral pathogens both with our external barriers such as skin as well as internally through the immune system. Mucin genes specifically Muc5AC and Muc5B help assist in this process by activating both bacterial and mucus pathogenesis. Their gene expression is correlated with temperature meaning that in warmer temperatures they have decreased expression. Developing a better understanding of their functionality as well as their expression can help species that are in danger of becoming extinct.

For African countries during the 1960s and 70s, decolonization marked the first step in a slow crawl toward complete independence. For Western powers and the Soviet Union, however, decolonization presented an opportunity to exert new influence over countries in desperate need of aid, investment, experts, and trade. Amidst the backdrop of increasing Cold War tensions, the US and USSR used foreign aid to pressure development according to either capitalist or Marxist agendas. Thus, sub-Saharan Africa became a battleground of proxy wars and neocolonialism. The Cold War superpowers would back opposing regimes in Angola and prop up, oust, or assassinate leaders in Ghana, Democratic Republic of the Congo, and Tanzania. This disrupted natural political development and created instability and violence, which was compounded by the arrival of the AIDS epidemic in the mid-1980s. AIDS ravaged African societies and destroyed the remaining fibers of leadership. The disease illuminated harsh historical realities as it spread among the conflict-stricken countries of sub-Saharan Africa. The goal of this thesis is to analyze the motivations behind US and USSR foreign aid during the Cold War, understand how their involvement halted the natural progression of pan-Africanism and leadership in newly-independent African countries, and link the resulting violence to the devastation of the AIDS crisis twenty years later. It begins with a look at European colonization in sub-Saharan Africa and traces the legacy of western influence in the region. The paper will then analyze specific examples of the consequences of historical interference, such as in the Angolan Civil War, the Congo Crisis, and the Rwandan genocide. It will introduce the AIDS crisis—coincident with major civil conflict and the end of the Cold War—and reveal the foreign aid response of the international community in the late 1990s and early 2000s, once Cold War-era pressures were gone. Through realizing the continued impact and spread of HIV/AIDS, the objective of this paper is to present a comprehensive view of the modern-day consequences of historical interference.

This paper provides a multidisciplinary analysis of the relationship between beauty and addiction, with a focus on the emerging field of neuroaesthetics. Neuroaesthetics investigates the neural mechanisms that underlie aesthetic experiences and how the brain cognitively processes beauty. Since there is a biological foundation of this report, I will predominantly discuss neuroanatomy, neurological studies, and the overlap in neural circuitry between beauty and addiction. In addition, I will discuss the philosophical roots of beauty, as well as the environmental elements involved. Chapter 1 begins by explaining the history of beauty and its importance. I discuss the main constituents of beauty and differentiate between key terms involved in the beauty experience. In order to understand the link between beauty and addiction, it is essential to have a knowledgeable background on what beauty is. Next, I discuss the neurobiology of addiction. The main component of this chapter involves the mesolimbic and mesocortical reward pathways. I also describe neuroanatomical terms involved in addiction. The last chapter considers the implications of neuroaesthetics in various studies, which primarily involve the use of fMRIs. I discuss the sensory evaluations of beauty and the brain regions involved in the beauty experience. From this, I found that the experience of beauty activates these main brain regions: PFC, amygdala, striatum, NAcc, cingulate, VTA, and most remarkably, field A1 of the mOFC. By combining the neurological studies with studies of aesthetics, I reached the conclusion that there is an overlap in the neural pathways during the experience of beauty and during addiction. Although it is necessary for further research to be conducted to properly declare this, I discovered that the pursuit of beauty can lead to addictive behaviors, as the reward centers of the brain are activated by aesthetic experiences.