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Description
Cystic Fibrosis (CF) is a genetic disorder that disrupts the hydration of mucous of the lungs, which promotes opportunistic bacterial infections that begin in the affected person’s childhood, and persist into adulthood. One of the bacteria that infect the CF lung is Pseudomonas aeruginosa. This gram-negative bacterium is acquired from the environment of the CF lung, changing the expression of phenotypes over the course of the infection. As P. aeruginosa infections become chronic, some phenotype changes are known to be linked with negative patient outcomes. An important exoproduct phenotype is rhamnolipid production, which is a glycolipid that P. aeruginosa produces as a surfactant for surface-mediated travel. Over time, the expression of this phenotype decreases in expression in the CF lung.
The objective of this investigation is to evaluate how environmental changes that are related to the growth environment in the CF lung alters rhamnolipid production. Thirty-five P. aeruginosa isolates from Dartmouth College and Seattle Children’s Hospital were selected to observe the impact of temperature, presence of Staphylococcus aureus metabolites, and oxygen availability on rhamnolipid production. It was found that the rhamnolipid production significantly decreased for 30C versus 37C, but not at 40C. The addition of S. aureus spent media, in any of the tested conditions, did not influence rhamnolipid production. Finally, the change in oxygen concentration from normoxia to hypoxia significantly reduced rhamnolipid production. These results were compared to swarming assay data to understand how changes in rhamnolipid production impact surface-mediated motility.
The objective of this investigation is to evaluate how environmental changes that are related to the growth environment in the CF lung alters rhamnolipid production. Thirty-five P. aeruginosa isolates from Dartmouth College and Seattle Children’s Hospital were selected to observe the impact of temperature, presence of Staphylococcus aureus metabolites, and oxygen availability on rhamnolipid production. It was found that the rhamnolipid production significantly decreased for 30C versus 37C, but not at 40C. The addition of S. aureus spent media, in any of the tested conditions, did not influence rhamnolipid production. Finally, the change in oxygen concentration from normoxia to hypoxia significantly reduced rhamnolipid production. These results were compared to swarming assay data to understand how changes in rhamnolipid production impact surface-mediated motility.
ContributorsKiermayr, Jonathan Patrick (Author) / Bean, Heather (Thesis director) / Misra, Rajeev (Committee member) / Haydel, Shelley (Committee member) / School of International Letters and Cultures (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
This project is to help Guatemalan youth immigrants by providing them with the information necessary to access support in the United States, and obtainin legal status in the United States. In order to produce a brochure with this information, it was necessary to research the political, economic, and social history of Guatemala in order to determine what struggles citizens are facing, and specifically what experiences youth in the country have prior to their journey to the United States. This research is culminated into a paper that discusses the history, the causes of emigration from Guatemala, and the status of youth immigrants before they leave Guatemala and once they arrive in the United States.
ContributorsMckay, Rachel Marie (Author) / Magaña, Lisa (Thesis director) / Elias, Olivia (Committee member) / School of Criminology and Criminal Justice (Contributor) / School of Politics and Global Studies (Contributor) / College of Letters and Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
This thesis explores the intersection of religion, social class, and politics during the late nineteenth century in Imperial Germany. Specifically, the focus of this work is on the Workers' Association of Saint Paul's in Aachen and Burtscheid, a Catholic working-class organization in the 1870s located in the city of Aachen, a rapidly industrializing city in the majority Catholic Prussian Rhineland. This organization was the largest Catholic working-class association in Germany in the 1870s, reaching 5,000 members by the middle of the decade, and also espoused the politics of Christian Socialism. This thesis explores the intersection of the possibly competing social identities of these workers between being Catholics and workers. To start, the scholarly framework of studying society and politics in Imperial Germany is discussed, especially the concept of rigidly constructed social milieus into five groups, two of them being the Catholics and the working-class, and how this work may suggest a challenge to this concept. Next, the background information of how a Catholic working-class came into existence, as it was the product of simultaneous nineteenth century processes of industrialization and a religious revival among German Catholics. The Kulturkampf was the force that politicized Catholicism in Germany, as the persecution of Catholic institutions by Prussia forced Catholics into a social and political "ghetto." Then, the Association of St. Paul's itself is discussed. First, the workers espoused their Catholic identity and religious solidarity during a time of persecution, but also emphasized the Christian basis for their brand of Socialism. This lent into their identity as part of the working-class. While they steadfastly rejected the "godlessness" of Social Democracy, the Christian Socialists also shared many similar social and political goals. This intersection between identities eventually led to political conflict in Aachen throughout the 1870s with the mainstream, bourgeois Catholics of the city. To conclude, the legacy of Christian Socialism on modern Germany is discussed, as well as its contribution to the complex politics of Imperial Germany.
ContributorsHarkness, John Hosea (Author) / Benkert, Volker (Thesis director) / Holian, Anna (Committee member) / School of Politics and Global Studies (Contributor) / School of International Letters and Cultures (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Often equated with hospice or end-of-life care, palliative care is the expansion of traditional disease-model medical treatments to include the goals of enhancing quality of life, facilitating patient autonomy, and addressing physical or emotional suffering. This interdisciplinary model is essential throughout the cancer continuum and offers the best patient outcomes when initiated at the time of diagnosis. While extensive research exists on the purpose and benefits of palliative care, substantial barriers to early and effective implementation remain. This study aims to examine and integrate current research literature on oncology nurses' perceptions of palliative care, including comparison to evidence-based preferred practice. Synthesis of qualitative findings offers transformative reconceptualization aimed to inform nursing education and improve patient care.
ContributorsScheller, Makena (Author) / Stevens, Carol (Thesis director) / Holcomb, Cynthia (Committee member) / Arizona State University. College of Nursing & Healthcare Innovation (Contributor) / School of Politics and Global Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Technology both stimulates and is simultaneously stimulated by people and society. As a classic example, games have shaped and have been shaped by people's preferences. Today, online computer games are roaming everywhere, attracting and connecting players all over the world. However, at the same time, a lesser form of technology has emerged alongside of online computer games. It is known as trading card games (TCGs). Surprisingly, TCGs have been able to compete on same level as online computer games. Looking at my past experiences, I offered a theory that encompasses three forms of social interactions to explain for TCGs' success. The three types of interactions are: interaction of identities, interaction of interests, and interaction of influences. Interaction of identities is the constant interchange of player information and knowledge through different mediums. Interaction of interests involves the exchange and quality of the tangible and intangible. Interaction of influences deals with the fluid flow of communication and ideas that players use to change an outcome, however consciously or unconsciously done. Not one of these three factors of interactions act along; each is a part of a grand picture of interaction of interactions. Altogether, these factors explain, at least in part, the current popularity of trading card games as a relatively simple technology in a society with a plethora of technologically advanced entertainments and games such as virtual computer gaming. A web-based survey was devised to further examine the effects of the three forms of interactions have on online computer game and trading card game players. The results were consistent with the premises of the three-factor interaction theory.
ContributorsQin, Sheng (Author) / Eaton, John P. (Thesis director) / Olsen, G. Douglas (Committee member) / Department of Psychology (Contributor) / Department of Management (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
In recent history, the world has been inspired to respond to the challenges faced by communities with ‘help’. This help has been administered with moderate success through community engagement strategies traditionally centered on social services provided through non-profit agencies. Social entrepreneurship has emerged in response to the lack of progress made in solving local and global issues with new innovations that have the potential to change the status quo and eliminate the problems for future generations. In social entrepreneurship, concerned individuals saw an opportunity to truly change the world. Higher education leaders have embraced social entrepreneurship, positioning university students as a driving force behind ideating creative and innovative solutions that can be implemented in communities to overcome a vast array of challenges from poverty to environmental sustainability. Despite the efforts of university staff and faculty, many student changemakers struggle to successfully implement their ideas and measure their impact. Factors such as how well the student understands the issue and community in addition to the extent to which the student is experienced in ideation, creative-problem solving, and implementation of projects contribute to the success or failure of a student social effort. Inspired by their experiences serving as director of Changemaker Central, the authors sought to understand the process of preparing students to be agents of change in the community. Having observed the variance in success among aspiring changemakers at Arizona State University (ASU), the researchers studied how to best support students in preparation for a high-impact career. The research analyzed students’ experiences in two of ASU’s social change programs, Changemaker Challenge (CC) and University Service-Learning (USL) and found a need for more cohesion between two programs and their represented methodologies in addition to a need for in-depth analysis on the student journey.
ContributorsMicevic, Vid (Co-author) / Fitzgerald, Kaitlyn (Co-author) / Henderson, Mark (Thesis director) / Smith, Jacqueline (Committee member) / Civil, Environmental and Sustainable Engineering Programs (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Abstract My documentary is about the concussion detection study with Arizona State Football, Translational Genomics Research Institute (TGen), Riddell and the Barrow Neurological Institute. Football players voluntarily participate in the study that aims to identify a biomarker released from the brain to identify if a player has suffered from a concussion. The study uses blood, urine and saliva samples, along with head impact data from Riddell's Sideline Response System. The study is also focusing on the impact of sub-concussive hits and the effects. According to the Barrow Neurological Institute, 84% of respondents believe concussions are "a serious medical condition," and a third of Valley parents will not let their children play football. I interviewed an ASU football player who participated in the study and found out about his experiences with concussions. The severity of concussions has received a lot of attention in recent years, and this study hopes to mitigate concussions symptoms and the fear of concussions. According to the 2015 NFL Health and Safety Report, since 2012 the NFL reported concussions were down by 35%. I interviewed the TGen leaders of the study and the neurologist at the Barrow Concussion and Brain Injury center involved in the study to find out how they plan to find a biomarker and use it to develop an objective way to diagnose concussions. An example of a possible objective test is a mouthguard that changes from clear to blue after a player sustained a hit that resulted in a concussion. The 2015-2016 ASU football season marked the study's third year of research. At the time of my documentary, the study had no timeline to release data.
ContributorsSeki, Katryna Marie (Author) / Lodato, Mark (Thesis director) / Kurland, Brett (Committee member) / Walter Cronkite School of Journalism and Mass Communication (Contributor) / School of Politics and Global Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Targeting Tumors: Inclusion of Functional Groups on Ion-Containing Block Copolymers to Combat Cancer
Description
This research attempts to determine the most effective method of synthesizing a peptide such that it can be utilized as a targeting moiety for polymeric micelles. Two melanoma-associated peptides with high in vitro and in vivo binding affinity for TNF receptors have been identified and synthesized. Matrix Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI-ToF) was used to help verify the structure of both peptides, which were purified using Reversed-Phase High Performance Liquid Chromatography (RP-HPLC). The next steps in the research are to attach the peptides to a micelle and determine their impact on micelle stability.
ContributorsMoe, Anna Marguerite (Author) / Green, Matthew (Thesis director) / Jones, Anne (Committee member) / Sullivan, Millicent (Committee member) / Chemical Engineering Program (Contributor) / School of International Letters and Cultures (Contributor) / Sandra Day O'Connor College of Law (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
This creative project consists of three short stories with a common theme of release, letting go, and exhalation. Nymphal Instar is a story about Tommy, a young boy, and his encounter with his uncle, a troubled man who has just returned from war. The story explores the idea of growth and maturation, and the ability to move past and let go of trauma. A Cat Goes Away is about a young man, Richard, who is required to simultaneously deal with the loss of his cat and the suicide attempts of his sister. He also runs into his sister's ex-husband and is forced to deal with him. The story explores the difficulty in recognizing one's own emotions and the importance of knowing the difference between what one can change and what one cannot. Since Diagnosis is a story about Kate, a woman who has just been diagnosed with cancer and who is unable to tell her loved ones. The story explores acceptance and the idea that letting go can allow one to live more fully. Though the three stories are disparate in their characters and events, they share a commonality in their endings and in the final realizations of the characters. There is a focus on the importance of breath and breathing, and the essentiality of acceptance and release.
ContributorsMyers, Alan Yutaka (Author) / McNally, T. M. (Thesis director) / Irish, Jenny (Committee member) / School of International Letters and Cultures (Contributor) / Department of English (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
DescriptionPanic at the Elbow: High School Baseball's Tommy John Surgery Epidemic reflects on the history of Tommy John surgery, examines the scale of the current epidemic, explores its underlying causes and ultimately recommends steps that parents and players can take to avoid such overuse injuries. Link to documentary: https://www.youtube.com/watch?v=31xvOCN_tqk
ContributorsMargiott, Benjamin James (Author) / Kurland, Brett (Thesis director) / Byck, Peter (Committee member) / Walter Cronkite School of Journalism and Mass Communication (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05