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- Member of: Barrett, The Honors College Thesis/Creative Project Collection
Description
Cell immunotherapies have revolutionized clinical oncology. While CAR T cell therapy has been very effective in clinical studies, off-target immune toxicity limits eligible patients. Thus, NK cells have been approached with the same therapy design since NK cells have a more favorable safety profile. Therefore, the purpose of this research project is to explore DNA nanotech-based NK cell engagers (NKCEs) that force an immunological synapse between the NK cell and the cancer cell, leading to cancer death. DNA tetrabody (TB) and DNA tetrahedron (TDN) are fabricated and armed with HER2 affibody for tight adhesion to HER2+ cancer cell lines like SKBR3. Overall, relationship between TB-NK treatment and cancer cell apoptosis is still unclear. TB-NK treatment induces an apoptotic profile similar to PMA/IO stimulation. Pilot cell assay needs to be replicated with additional controls and a shortened treatment window. For DNA TDN fabrication, HER2 affibody polishing with Ni-NTA affinity chromatography achieves high purity with 20% to 100% high-imidazole elution gradient. ssDNA-HER2 affibody conjugation is optimal when ssDNA is treated with 40-fold excess sulfo-SMCC for 4 hours. In conclusion, the manufacturing of DNA-based NKCEs is rapid and streamlined, which gives these NKCEs the potential to become a ready to use immunotherapy.
ContributorsLuca, Michael (Author) / Yan, Hao (Thesis director) / Stephanopoulos, Nicholas (Committee member) / Blattman, Joseph (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / School of International Letters and Cultures (Contributor) / School of Molecular Sciences (Contributor)
Created2024-05
ContributorsLuca, Michael (Author) / Yan, Hao (Thesis director) / Stephanopoulos, Nicholas (Committee member) / Blattman, Joseph (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / School of International Letters and Cultures (Contributor) / School of Molecular Sciences (Contributor)
Created2024-05
Description
This narrative literature review explores how perceived stress affects sleep quality in dementia caregivers by examining various factors. Ten studies from 2013 to 2022 across four continents were analyzed, focusing on caregiver stress levels, sleep quality, caregiver burden, and depression. Higher stress levels were linked to poorer sleep quality, alongside factors like emotional distress and disrupted sleep patterns. The findings highlight the importance of targeted interventions to reduce stress and improve sleep quality among dementia caregivers, suggesting the need for longitudinal and empirical studies with standardized measures for a better understanding.
ContributorsBadhwar, Karan (Author) / Giasson, Hannah (Thesis director) / Koffer, Rachel (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / School of Life Sciences (Contributor) / Department of Psychology (Contributor)
Created2024-05
Description
With the reality that 60% of post-graduates are less satisfied with their social life in adulthood than in college, many young adults find themselves searching to solve the shared fear of finding communities in new spheres of life. Jillian Cote and Mia Cavalier's social application concept, "The Loop", addresses this problem through unique recommendations based on location services, authentic UGC, and entertaining digital appearances. Through extensive research and development, a prototype has been designed for the application interface, and intensive surveys and interviews have been conducted to pinpoint target markets, consumer interest, and ultimate adoption potential.
At its core, "The Loop" is a modern, efficient, and functional social application for young adults and post-graduates to stay connected to key parts of their lives regardless of the life phase they’re in. It allows each individual to focus on what’s important to them, while the app keeps them in the loop for everything else.
ContributorsCote, Jillian (Author) / Cavalier, Mia (Co-author) / Byrne, Jared (Thesis director) / Swader, Melissa (Committee member) / Barrett, The Honors College (Contributor) / Dean, W.P. Carey School of Business (Contributor) / School of International Letters and Cultures (Contributor) / Department of Marketing (Contributor)
Created2024-05
Description
This thesis is a continuation of the Humanities Lab “Narratives of School Shootings” class, which analyzed the impact of school violence on students and communities and examined the narratives and factors that exist relating to school shootings. A primary focus of the class was youth activism and advocacy. In collaboration with the Greenlights Grant Initiative, which was created to combat violence in schools, Barrett students were partnered with school districts to assist in grant writing. Using projects from “Narratives of School Shootings”, the team deduced which grants best supported each school district and worked with the districts to write and submit them. These grants are used for proactive and reactive measures to keep student emotionally and physically sound. Through this process, Barrett students analyzed the intricacies of grant writing and government funding, as well as how those contribute to cycles of inequality.
ContributorsBrammer, Elizabeth (Author) / Miller, Allison (Co-author) / Zimmerman, Daniel (Co-author) / Lindstrom Johnson, Sarah (Thesis director) / Blasingame, James (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / Department of English (Contributor)
Created2024-05
ContributorsSanchez, Tomas (Author) / Casanova, Pablo (Co-author) / Green, Aaron (Co-author) / Dalvi, Tejas (Co-author) / Dudas, Caleb (Co-author) / Byrne, Jared (Thesis director, Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / Department of Finance (Contributor)
Created2024-05
ContributorsSanchez, Tomas (Author) / Casanova, Pablo (Co-author) / Green, Aaron (Co-author) / Dalvi, Tejas (Co-author) / Dudas, Caleb (Co-author) / Byrne, Jared (Thesis director, Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / Department of Finance (Contributor)
Created2024-05
ContributorsSanchez, Tomas (Author) / Casanova, Pablo (Co-author) / Green, Aaron (Co-author) / Dalvi, Tejas (Co-author) / Dudas, Caleb (Co-author) / Byrne, Jared (Thesis director, Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / Department of Finance (Contributor)
Created2024-05
ContributorsSanchez, Tomas (Author) / Casanova, Pablo (Co-author) / Green, Aaron (Co-author) / Dalvi, Tejas (Co-author) / Dudas, Caleb (Co-author) / Byrne, Jared (Thesis director, Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / Department of Finance (Contributor)
Created2024-05
Description
After traveling to Spain to study abroad, I noticed a large amount of shops selling goods related to Japanese anime, which helped inspire the topic of my honors thesis. In this paper, the cultural impact of Japanese animation and comics on Spain is explored. The history/origin of anime in Spain, the early reception of these works in Spain, the importance of the anime fandom, the intersection between Spanish and Japanese culture in anime and anime-inspired films, and the positive representation of Spain in these works are all relevant topics that constitute the argument of this document. Sources in both English and Spanish are utilized.This paper explores the surprising connections between the two countries. The way in which their cultures interact through the consumption of this form of media was quite fascinating to look into.
ContributorsMalinski, Joseph (Author) / Walton-Ramirez, Anne (Thesis director) / Wilson, Bradley (Committee member) / Barrett, The Honors College (Contributor) / School of Geographical Sciences and Urban Planning (Contributor) / School of International Letters and Cultures (Contributor)
Created2024-05