Fluoroquinolone antibiotics have been known to cause severe, multisystem adverse side effects, termed fluoroquinolone toxicity (FQT). This toxicity syndrome can present with adverse effects that vary from individual to individual, including effects on the musculoskeletal and nervous systems, among others. The mechanism behind FQT in mammals is not known, although various possibilities have been investigated. Among the hypothesized FQT mechanisms, those that could potentially explain multisystem toxicity include off-target mammalian topoisomerase interactions, increased production of reactive oxygen species, oxidative stress, and oxidative damage, as well as metal chelating properties of FQs. This review presents relevant information on fluoroquinolone antibiotics and FQT and explores the mechanisms that have been proposed. A fluoroquinolone-induced increase in reactive oxygen species and subsequent oxidative stress and damage presents the strongest evidence to explain this multisystem toxicity syndrome. Understanding the mechanism of FQT in mammals is important to aid in the prevention and treatment of this condition.

A growing body of research suggests a link between adverse childhood experiences and negative health outcomes. However, less is known about where racial discrimination ranks compared to other adverse childhood experiences, such as maltreatment. To address this issue, I conducted two systematic reviews of meta-analyses to compare the magnitudes of the links between racial discrimination and depressive symptoms and childhood maltreatment and depressive symptoms. My aim was to establish if racial discrimination should be considered an adverse childhood experience. My results demonstrated that the link between racial discrimination and depressive symptoms (r = 0.27) is comparable to the links between 4 different manifestations of maltreatment and depressive symptoms (physical abuse: r = 0.257, emotional abuse: r = 0.301, neglect: r = 0.381, sexual abuse: r = 0.408). I discuss the implications of these findings and propose future research directions.

When you are sitting at the terminal waiting for your flight or taking the bus to get to work, have you ever thought about who used your seat last? More importantly, have you ever thought about the last time that seat was cleaned? Sadly, it is uncertain to see if it was properly sanitized in the last hour, yesterday, in the last week, or even last month. Especially during these tough times, everyone wants to be assured that they are always in a safe and healthy environment. Through the Founders Lab, our team is collaborating with an engineering capstone team to bring automated seat cleaning technology into the market. This product is a custom-designed seat cover that is tear-resistant and provides a sanitary surface for anyone to sit on. When someone leaves the seat, a pressure sensor is triggered, and the cover is replaced with a secondary cover that was stored in a UV radiated container. The waterproof fabric and internal filters prevent spills and food crumbs from remaining when the user changes. The reason for bringing this product into the market is due to the unsanitary conditions in many high traffic areas. This technology can be implemented in public transportation, restaurants, sports stadiums, and much more. It will instantly improve the efficiency of sanitation for many businesses and keep a promise to its users that they will never bring something they sat on back home. #Safeseating

Water quality and accessibility can impact most aspects of life such as hygiene, medicine, thermal comfort, sewage disposal, and health, to name a few. Rising concerns related to the quality of drinking water in the United States caused by municipal water utility failures such as in Texas or in Michigan has led to an inquiry into the root cause of how a supply-chain for a basic necessity such as water can run into issues. After initial research and investigation, one hypothesis for this was the nature of how recyclable materials in a linear economy eventually run into production or storage problems as exhaustible resources (or space) become less accessible over time. To remedy this issue, LifeGear360 is introduced to allow individual users the liberty to treat their water directly if needed, while also remaining in a circular economy for the lifecycle of the product. As a backpack with water treatment capabilities, natural plant fibers are used to ensure a renewable cycle of production while also redefining the traditional “plastic-taste” characteristics many people associate with water pouches to a smoother, cleaner taste. Engineering, sustainability, and business and public service practice have been used in an interdisciplinary way to prepare this product for its intended use such as in school, for travel, and for the outdoors. According to the collected outreach, many indicated that they feel as though there is a need for a product that allows for the feeling of water security which can include carrying any personal belongings as well. Marketing strategies such as logo creating and online outreach continually influence product design, up until production would take place following the finalized design.

Geology and its tangential studies, collectively known and referred to in this thesis as geosciences, have been paramount to the transformation and advancement of society, fundamentally changing the way we view, interact and live with the surrounding natural and built environment. It is important to recognize the value and importance of this interdisciplinary scientific field while reconciling its ties to imperial and colonizing extractive systems which have led to harmful and invasive endeavors. This intersection among geosciences, (environmental) justice studies, and decolonization is intended to promote inclusive pedagogical models through just and equitable methodologies and frameworks as to prevent further injustices and promote recognition and healing of old wounds. By utilizing decolonial frameworks and highlighting the voices of peoples from colonized and exploited landscapes, this annotated syllabus tackles the issues previously described while proposing solutions involving place-based education and the recentering of land within geoscience pedagogical models. (abstract)