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Description
Orbiting space debris is an active issue that affects the capability of space launch for future satellites, probes, and space shuttles, and it will become a nearly insurmountable problem without action. Debris of varying sizes and speeds orbit the Earth at a range of heights above the atmosphere and need to be removed to avoid damage to crucial equipment of active orbiting satellites including the International Space Station. Finding a feasible solution to space debris removal requires that several facets be covered to become a reality; these include being aware of the problem in magnitude and source. This literature assessment covers the magnitude of space debris in low-earth and geosynchronous orbit as well as collision events which have increased the amount of space debris. There have been efforts made by several space agencies to control the amount of space debris added to orbit by current and future launches over the last decade \u2014 serving as a temporary fix before removal can be executed. This paper explores known removal efforts through mitigation, projects conceived and tested by DARPA, related space policies and laws, CubeSat technology, and the cataloguing of known space debris. To make space debris removal a reality, roadblocks need to be removed to acquire permission from states or countries for space missions. For example, these restrictions are in place to protect the assets of several countries and organizations. Guidelines set to curb the growth of space debris fail to prevent the growth due to the restrictions for ownership rights making them not as effective. This paper covers space policy and laws, the economy, satellite ownership, international conflict, status of space debris, and the overall feasibility of space debris removal. It will then discuss currently proposed solutions for the removal of space debris. Finally, this paper attempts to weight the advantages and disadvantages of the idea that space debris removal should include the opportunity to recycle materials. For example, defunct satellites and other discarded space crafts could be used for future launches. It will conclude with a personal exploration of what materials can be recycled, what chemical processes can be used to break down materials, and how to combine recycling and chemical processes for space-based recycling stations between Earth and the moon. The overall question that drives the search for making space debris removal a reality is whether it is feasible in multiple areas including technologically, legally, monetarily, and physically.
ContributorsBreden, Elizabeth Catherine (Author) / Foy, Joseph (Thesis director) / Thoesen, Andrew (Committee member) / Maximon, Leonard (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
Brown adipose tissue (BAT) is thought to be important in combating obesity as it can expend energy in the form of heat, e.g. thermogenesis. The goal of this study was to study the effect of injected norepinephrine (NE) on the activation of BAT in rats that were fed a high fat diet (HFD). A dose of 0.25 mg/kg NE was used to elicit a temperature response that was measured using transponders inserted subcutaneously over the BAT and lower back and intraperitoneally to measure the core temperature. The results found that the thermic effect of the BAT increased after the transition from low fat diet to a high fat diet (LFD) yet, after prolonged exposure to the HFD, the effects resembled levels found with the LFD. This suggests that while a HFD may stimulate the effect of BAT, long term exposure may have adverse effects on BAT activity. This may be due to internal factors that will need to be examined further.
ContributorsSion, Paul William (Author) / Herman, Richard (Thesis director) / Borges, Chad (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
Father Daniel Berrigan once said that "writing about prisoners is a little like writing about the dead." I think what he meant is that we treat prisoners as ghosts. They're unseen and unheard. It's easy to simply ignore them and it's even easier when the government goes to great lengths to keep them hidden.
Supermax prisons are used to hold those prisoners whom prison authorities regard as the most problematic in the prison system. These facilities merge the 19th-century practice of long-term solitary confinement with 21st-century technology in ways that subject prisoners to unparalleled levels of isolation, surveillance, and control, usually for long duration, with the potential to inflict significant amounts of psychological harm. Despite a range of academic studies documenting the serious and potentially long-lasting psychological harm it may inflict, and several judicial opinions criticizing the risks it entails and significantly limiting its use, supermax prisons are still in full effect today.
Although there have been no successful cases brought to the Supreme Court alleging the use of supermax prisons being in violation of the inmate’s Eighth Amendment right, one can look at isolated factors that distinguish supermax prisons in which judges at the Supreme Court level have shown to be unconstitutional in general population prisons. This thesis examines the Eighth Amendment implications of cruel and unusual punishment within supermax prisons, through isolated factors through judicial intervention.
Supermax prisons are used to hold those prisoners whom prison authorities regard as the most problematic in the prison system. These facilities merge the 19th-century practice of long-term solitary confinement with 21st-century technology in ways that subject prisoners to unparalleled levels of isolation, surveillance, and control, usually for long duration, with the potential to inflict significant amounts of psychological harm. Despite a range of academic studies documenting the serious and potentially long-lasting psychological harm it may inflict, and several judicial opinions criticizing the risks it entails and significantly limiting its use, supermax prisons are still in full effect today.
Although there have been no successful cases brought to the Supreme Court alleging the use of supermax prisons being in violation of the inmate’s Eighth Amendment right, one can look at isolated factors that distinguish supermax prisons in which judges at the Supreme Court level have shown to be unconstitutional in general population prisons. This thesis examines the Eighth Amendment implications of cruel and unusual punishment within supermax prisons, through isolated factors through judicial intervention.
ContributorsLucca, Veronica Cristina (Author) / Stanford, Michael (Thesis director) / Cavender, Gray (Committee member) / School of Social Transformation (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
Cystic Fibrosis (CF) is a genetic disorder that disrupts the hydration of mucous of the lungs, which promotes opportunistic bacterial infections that begin in the affected person’s childhood, and persist into adulthood. One of the bacteria that infect the CF lung is Pseudomonas aeruginosa. This gram-negative bacterium is acquired from the environment of the CF lung, changing the expression of phenotypes over the course of the infection. As P. aeruginosa infections become chronic, some phenotype changes are known to be linked with negative patient outcomes. An important exoproduct phenotype is rhamnolipid production, which is a glycolipid that P. aeruginosa produces as a surfactant for surface-mediated travel. Over time, the expression of this phenotype decreases in expression in the CF lung.
The objective of this investigation is to evaluate how environmental changes that are related to the growth environment in the CF lung alters rhamnolipid production. Thirty-five P. aeruginosa isolates from Dartmouth College and Seattle Children’s Hospital were selected to observe the impact of temperature, presence of Staphylococcus aureus metabolites, and oxygen availability on rhamnolipid production. It was found that the rhamnolipid production significantly decreased for 30C versus 37C, but not at 40C. The addition of S. aureus spent media, in any of the tested conditions, did not influence rhamnolipid production. Finally, the change in oxygen concentration from normoxia to hypoxia significantly reduced rhamnolipid production. These results were compared to swarming assay data to understand how changes in rhamnolipid production impact surface-mediated motility.
The objective of this investigation is to evaluate how environmental changes that are related to the growth environment in the CF lung alters rhamnolipid production. Thirty-five P. aeruginosa isolates from Dartmouth College and Seattle Children’s Hospital were selected to observe the impact of temperature, presence of Staphylococcus aureus metabolites, and oxygen availability on rhamnolipid production. It was found that the rhamnolipid production significantly decreased for 30C versus 37C, but not at 40C. The addition of S. aureus spent media, in any of the tested conditions, did not influence rhamnolipid production. Finally, the change in oxygen concentration from normoxia to hypoxia significantly reduced rhamnolipid production. These results were compared to swarming assay data to understand how changes in rhamnolipid production impact surface-mediated motility.
ContributorsKiermayr, Jonathan Patrick (Author) / Bean, Heather (Thesis director) / Misra, Rajeev (Committee member) / Haydel, Shelley (Committee member) / School of International Letters and Cultures (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
The following paper discusses the validation of the TolTEC optical design along with a progress report regarding the design of the optical mounting system. Solidworks and Zemax were used in conjunction to model the proposed optics designs. The final optical design was selected through extensive CAD modeling and testing within the Large Millimeter Telescope receiver room. The TolTEC optics can be divided into two arrays, one comprised of the warm mirrors and the second, cryogenically-operated cold mirrors. To ensure structural stability and optical performance, the mechanical design of these systems places a heavy emphasis on rigidity. This is done using a variety of design techniques that restrict motion along the necessary degrees of freedom and maximize moment of inertia while minimizing weight. Work will resume on this project in the Fall 2017 semester.
ContributorsKelso, Rhys Partain (Author) / Mauskopf, Philip (Thesis director) / Groppi, Christopher (Committee member) / Mechanical and Aerospace Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
Almost every form of cancer deregulates the expression and activity of anabolic glycosyltransferase (GT) enzymes, which incorporate particular monosaccharides in a donor acceptor as well as linkage- and anomer-specific manner to assemble complex and diverse glycans that significantly affect numerous cellular events, including tumorigenesis and metastasis. Because glycosylation is not template-driven, GT deregulation yields heterogeneous arrays of aberrant intact glycan products, some in undetectable quantities in clinical bio-fluids (e.g., blood plasma). Numerous glycan features (e.g., 6 sialylation, β-1,6-branching, and core fucosylation) stem from approximately 25 glycan “nodes:” unique linkage specific monosaccharides at particular glycan branch points that collectively confer distinguishing features upon glycan products. For each node, changes in normalized abundance (Figure 1) may serve as nearly 1:1 surrogate measure of activity for culpable GTs and may correlate with particular stages of carcinogenesis. Complementary to traditional top down glycomics, the novel bottom-up technique applied herein condenses each glycan node and feature into a single analytical signal, quantified by two GC-MS instruments: GCT (time-of-flight analyzer) and GCMSD (transmission quadrupole analyzers). Bottom-up analysis of stage 3 and 4 breast cancer cases revealed better overall precision for GCMSD yet comparable clinical performance of both GC MS instruments and identified two downregulated glycan nodes as excellent breast cancer biomarker candidates: t-Gal and 4,6-GlcNAc (ROC AUC ≈ 0.80, p < 0.05). Resulting from the activity of multiple GTs, t-Gal had the highest ROC AUC (0.88) and lowest ROC p‑value (0.001) among all analyzed nodes. Representing core-fucosylation, glycan node 4,6-GlcNAc is a nearly 1:1 molecular surrogate for the activity of α-(1,6)-fucosyltransferase—a potential target for cancer therapy. To validate these results, future projects can analyze larger sample sets, find correlations between breast cancer stage and changes in t-Gal and 4,6-GlcNAc levels, gauge the specificity of these nodes for breast cancer and their potential role in other cancer types, and develop clinical tests for reliable breast cancer diagnosis and treatment monitoring based on t-Gal and 4,6-GlcNAc.
ContributorsZaare, Sahba (Author) / Borges, Chad (Thesis director) / LaBaer, Joshua (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
This thesis explores the intersection of religion, social class, and politics during the late nineteenth century in Imperial Germany. Specifically, the focus of this work is on the Workers' Association of Saint Paul's in Aachen and Burtscheid, a Catholic working-class organization in the 1870s located in the city of Aachen, a rapidly industrializing city in the majority Catholic Prussian Rhineland. This organization was the largest Catholic working-class association in Germany in the 1870s, reaching 5,000 members by the middle of the decade, and also espoused the politics of Christian Socialism. This thesis explores the intersection of the possibly competing social identities of these workers between being Catholics and workers. To start, the scholarly framework of studying society and politics in Imperial Germany is discussed, especially the concept of rigidly constructed social milieus into five groups, two of them being the Catholics and the working-class, and how this work may suggest a challenge to this concept. Next, the background information of how a Catholic working-class came into existence, as it was the product of simultaneous nineteenth century processes of industrialization and a religious revival among German Catholics. The Kulturkampf was the force that politicized Catholicism in Germany, as the persecution of Catholic institutions by Prussia forced Catholics into a social and political "ghetto." Then, the Association of St. Paul's itself is discussed. First, the workers espoused their Catholic identity and religious solidarity during a time of persecution, but also emphasized the Christian basis for their brand of Socialism. This lent into their identity as part of the working-class. While they steadfastly rejected the "godlessness" of Social Democracy, the Christian Socialists also shared many similar social and political goals. This intersection between identities eventually led to political conflict in Aachen throughout the 1870s with the mainstream, bourgeois Catholics of the city. To conclude, the legacy of Christian Socialism on modern Germany is discussed, as well as its contribution to the complex politics of Imperial Germany.
ContributorsHarkness, John Hosea (Author) / Benkert, Volker (Thesis director) / Holian, Anna (Committee member) / School of Politics and Global Studies (Contributor) / School of International Letters and Cultures (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Technology both stimulates and is simultaneously stimulated by people and society. As a classic example, games have shaped and have been shaped by people's preferences. Today, online computer games are roaming everywhere, attracting and connecting players all over the world. However, at the same time, a lesser form of technology has emerged alongside of online computer games. It is known as trading card games (TCGs). Surprisingly, TCGs have been able to compete on same level as online computer games. Looking at my past experiences, I offered a theory that encompasses three forms of social interactions to explain for TCGs' success. The three types of interactions are: interaction of identities, interaction of interests, and interaction of influences. Interaction of identities is the constant interchange of player information and knowledge through different mediums. Interaction of interests involves the exchange and quality of the tangible and intangible. Interaction of influences deals with the fluid flow of communication and ideas that players use to change an outcome, however consciously or unconsciously done. Not one of these three factors of interactions act along; each is a part of a grand picture of interaction of interactions. Altogether, these factors explain, at least in part, the current popularity of trading card games as a relatively simple technology in a society with a plethora of technologically advanced entertainments and games such as virtual computer gaming. A web-based survey was devised to further examine the effects of the three forms of interactions have on online computer game and trading card game players. The results were consistent with the premises of the three-factor interaction theory.
ContributorsQin, Sheng (Author) / Eaton, John P. (Thesis director) / Olsen, G. Douglas (Committee member) / Department of Psychology (Contributor) / Department of Management (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
In recent history, the world has been inspired to respond to the challenges faced by communities with ‘help’. This help has been administered with moderate success through community engagement strategies traditionally centered on social services provided through non-profit agencies. Social entrepreneurship has emerged in response to the lack of progress made in solving local and global issues with new innovations that have the potential to change the status quo and eliminate the problems for future generations. In social entrepreneurship, concerned individuals saw an opportunity to truly change the world. Higher education leaders have embraced social entrepreneurship, positioning university students as a driving force behind ideating creative and innovative solutions that can be implemented in communities to overcome a vast array of challenges from poverty to environmental sustainability. Despite the efforts of university staff and faculty, many student changemakers struggle to successfully implement their ideas and measure their impact. Factors such as how well the student understands the issue and community in addition to the extent to which the student is experienced in ideation, creative-problem solving, and implementation of projects contribute to the success or failure of a student social effort. Inspired by their experiences serving as director of Changemaker Central, the authors sought to understand the process of preparing students to be agents of change in the community. Having observed the variance in success among aspiring changemakers at Arizona State University (ASU), the researchers studied how to best support students in preparation for a high-impact career. The research analyzed students’ experiences in two of ASU’s social change programs, Changemaker Challenge (CC) and University Service-Learning (USL) and found a need for more cohesion between two programs and their represented methodologies in addition to a need for in-depth analysis on the student journey.
ContributorsMicevic, Vid (Co-author) / Fitzgerald, Kaitlyn (Co-author) / Henderson, Mark (Thesis director) / Smith, Jacqueline (Committee member) / Civil, Environmental and Sustainable Engineering Programs (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Popular Culture of today, particularly books and movies have begun to influence the way individ- uals and society as a whole, views specific concepts. In this case, the fairly recent phenomenon of the Sci- ence Fiction Drug Niche has produced significant thought among audiences as to both the benefits and costs of cognitive enhancers in our world. Through the use of both a thorough analysis of modern films and novels on the topic as well as focus groups of the average college students this study analyzes the influence that this niche has had on the perceptions that students have towards the use of such cognitive enhancements. Small groups of students were shown the same film: Limitless, and discussion after the film displayed the students thoughts and attitudes towards the ideas shown in the film. Limitless itself falls into this Science Fiction drug niche and discusses both benefits and harms of chemical cognitive enhancement. The study indicates that audiences have thought not only about the issues that may arise with the presence of cognitive enhancement in our world but also the possible benefits of this enhancement. The results go even further to preliminarily show that there are common thoughts that arise in such situations. These common ideas that arise show, at least on a very basic level, that the presence of these Science Fiction Drug-inspired works are influencing the way audiences perceive the use of cognitive enhancement as well as influencing what doubts, questions, hopes, and fears arise from these pharmaceuticals. This preliminary study could use further research to ana- lyze the effects of popular culture on perceptions of cognitive enhancement and pharmaceuticals to alter consciousness.
ContributorsSyed, Mariha Batool (Author) / Zachary, Gregg (Thesis director) / Hurlbut, Ben (Committee member) / School of Historical, Philosophical and Religious Studies (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05